Long-term exposure of Syrian hamsters and Osborne-Mendel rats to aerosolized 0. 45-. mu. M mean-diameter fibrous glass

Conference · Fri Jan 01 00:00:00 EST 1982

OSTI ID:5027157

Smith, D M; Ortiz, L W; Archuleta, R F

Male Syrian hamsters and female Osborne-Mendel rats were exposed for 24 months to one of two levels of an aerosolized fine-diameter fibrous glass (0.45-..mu..m mean diameter). The high-level exposure had a mass concentration of approx. 3 mg/m/sup 3/ (3000 fibers/cm/sup 3/) and the low-level exposure, approx. 0.3 mg/m/sup 3/ (300 fibers/cm/sup 3/). At the higher level, approximately 500 fibers/cm/sup 3/ were longer than 10 ..mu..m. After the 24-month exposure, the animals were maintained for the rest of their lives. Sham and unmanipulated cage controls were included for each species. No significant detrimental biological effects were observed in the hamsters. In fact, the exposed hamsters significantly outlived both the sham and cage controls. Several of the rats in the study are still alive. To date, no unusual changes have been observed in either pulmonary or extrapulmonary tissues of the rats.

• Research Organization: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
• DOE Contract Number: W-7405-ENG-36
• OSTI ID: 5027157
• Report Number(s): LA-UR-82-2300; CONF-820477-1; ON: DE82021923
• Resource Relation: Conference: World Health Organization symposium on biological effects of man-made mineral fibers, Copenhagen, Denmark, 20 Apr 1982; Other Information: Portions of document are illegible
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
FIBERGLASS
BIOLOGICAL EFFECTS
HAMSTERS
SENSITIVITY
RATS
CHRONIC EXPOSURE
COMPARATIVE EVALUATIONS
EXPOSURE CHAMBERS
FEMALES
INHALATION
LUNGS
MALES
ANIMALS
BODY
INTAKE
MAMMALS
ORGANS
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)