Receptor-DNA binding to target auger electrons for cancer therapy. Final report, August 1, 1993--January 31, 1997
The goal of this program was to investigate the principle of receptor-DNA binding as a means to target Auger electron radiation for cancer therapy, and thereby to evaluate the potential of non-covalent, high-affinity, Auger electron-emitting ligands binding to a DNA associated molecule, or DNA itself, for cancer therapy. These studies were intended to assess the ability of Auger-emitting estrogens to kill estrogen receptor-positive tumor cells, determine the mean lethal dose, and determine whether they could be effective in vitro and in vivo.
- Research Organization:
- Chicago Univ., IL (United States). Ben May Inst.
- Sponsoring Organization:
- USDOE Office of Energy Research, Washington, DC (United States)
- DOE Contract Number:
- FG02-93ER61655
- OSTI ID:
- 477720
- Report Number(s):
- DOE/ER/61655-T1; ON: DE97006056; TRN: 97:003556
- Resource Relation:
- Other Information: PBD: [1997]
- Country of Publication:
- United States
- Language:
- English
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