Regional deposition of thoron progeny in models of the human tracheobronchial tree
Models of the human tracheobronchial tree have been used to determine total and regional aerosol deposition of inhaled particles. Particle sizes measured in these studies have all been > 40 nm in diameter. The deposition of aerosols < 40 nm in diameter has not been measured. Particles in the ultrafine aerosol size range include some combustion aerosols and indoor radon progeny. Also, the influence of reduced lung size and airflow rates on particle deposition in young children has not been determined. With their smaller lung size and smaller minute volumes, children may be at increased risk from ultrafine pollutants. In order to accurately determine dose of inhaled aerosols, the effects of particle size, minute volume, and age at exposure must be quantified. The purpose of this study was to determine the deposition efficiency of ultrafine aerosols smaller than 40 nm in diameter in models of the human tracheobronchia tree. This study demonstrates that the deposition efficiency of aerosols in the model of the child`s tracheobronchial tree may be slightly higher than in the adult models.
- Research Organization:
- Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (United States). Inhalation Toxicology Research Inst.
- OSTI ID:
- 381811
- Report Number(s):
- ITRI-146; ON: DE96008986; TRN: 96:002767-0011
- Resource Relation:
- Other Information: PBD: Dec 1995; Related Information: Is Part Of Inhalation Toxicology Research Institute. Annual report, October 1, 1994--September 30, 1995; Bice, D.E.; Hahn, F.F.; Hoover, M.D.; Neft, R.E.; Thornton-Manning, J.R.; Bradley, P.L. [eds.]; PB: 214 p.
- Country of Publication:
- United States
- Language:
- English
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