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Title: Microscopic distribution patterns of microspheres deposited by inhalation in lungs of rats, guinea pigs, and dogs

Abstract

Acute inhalation exposures of mammalian species to small amounts of poorly soluble particles result in deposition of the particles in the head airways, tracheobronchial region, and pulmonary region of the respiratory tract. Most of the particles that deposit in the head airways and tracheobronchial region are believed to clear rapidly, but some as yet undefined fraction of the particles is retained in the airway epithelium or subepithelial interstitium for extended times. This long-term retention has important implications for the new respiratory tract dosimetry model of the International Commission on Radiological Protection because particles retained within the region can result in long-term exposure of airway epithelial cells. Preliminary results from this study demonstrate that a substantial fraction of the PSL microspheres inhaled by these rats, guinea pigs, and dogs was incorporated into the epithelium and interstitium of the tracheobronchial region.

Authors:
; ;
Publication Date:
Research Org.:
Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (United States). Inhalation Toxicology Research Inst.
OSTI Identifier:
381361
Report Number(s):
ITRI-146
ON: DE96008986; TRN: 96:002767-0015
DOE Contract Number:  
AC04-76EV01013
Resource Type:
Technical Report
Resource Relation:
Other Information: PBD: Dec 1995; Related Information: Is Part Of Inhalation Toxicology Research Institute. Annual report, October 1, 1994--September 30, 1995; Bice, D.E.; Hahn, F.F.; Hoover, M.D.; Neft, R.E.; Thornton-Manning, J.R.; Bradley, P.L. [eds.]; PB: 214 p.
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; 56 BIOLOGY AND MEDICINE, APPLIED STUDIES; MAMMALS; LUNGS; MICROSPHERES; DEPOSITION; SPATIAL DISTRIBUTION; INHALATION; HAZARDOUS MATERIALS; PROGRESS REPORT; RATS; DOGS; GUINEA PIGS

Citation Formats

Snipes, M. B., Guilmette, R. A., and Nikula, K. J. Microscopic distribution patterns of microspheres deposited by inhalation in lungs of rats, guinea pigs, and dogs. United States: N. p., 1995. Web. doi:10.2172/381361.
Snipes, M. B., Guilmette, R. A., & Nikula, K. J. Microscopic distribution patterns of microspheres deposited by inhalation in lungs of rats, guinea pigs, and dogs. United States. https://doi.org/10.2172/381361
Snipes, M. B., Guilmette, R. A., and Nikula, K. J. 1995. "Microscopic distribution patterns of microspheres deposited by inhalation in lungs of rats, guinea pigs, and dogs". United States. https://doi.org/10.2172/381361. https://www.osti.gov/servlets/purl/381361.
@article{osti_381361,
title = {Microscopic distribution patterns of microspheres deposited by inhalation in lungs of rats, guinea pigs, and dogs},
author = {Snipes, M. B. and Guilmette, R. A. and Nikula, K. J.},
abstractNote = {Acute inhalation exposures of mammalian species to small amounts of poorly soluble particles result in deposition of the particles in the head airways, tracheobronchial region, and pulmonary region of the respiratory tract. Most of the particles that deposit in the head airways and tracheobronchial region are believed to clear rapidly, but some as yet undefined fraction of the particles is retained in the airway epithelium or subepithelial interstitium for extended times. This long-term retention has important implications for the new respiratory tract dosimetry model of the International Commission on Radiological Protection because particles retained within the region can result in long-term exposure of airway epithelial cells. Preliminary results from this study demonstrate that a substantial fraction of the PSL microspheres inhaled by these rats, guinea pigs, and dogs was incorporated into the epithelium and interstitium of the tracheobronchial region.},
doi = {10.2172/381361},
url = {https://www.osti.gov/biblio/381361}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Fri Dec 01 00:00:00 EST 1995},
month = {Fri Dec 01 00:00:00 EST 1995}
}