skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Development of more efficacious Tc-99m organ imaging agents for use in nuclear medicine by characterization of radiopharmaceuticals. Final report, September 1, 1992--June 30, 1998

Abstract

The primary goals of this project were twofold: (1) Development of a microsensor that would demonstrate the capability for in vivo monitoring of a radiopharmaceutical after its injection into a test animal; and (2) Exploration of capillary electrophoresis (CE) as a separation technique for the analysis of radiopharmaceuticals that are mixtures of different compounds. The combination of in vivo sensors for real-time monitoring of specific chemical states of a radiopharmaceutical in individual organs and CE for analysis of radiopharmaceuticals prior to injection would provide valuable information regarding the fate of an imaging agent after administration. Such information should give insight into strategies for the development of more efficacious radiopharmaceuticals.

Authors:
;
Publication Date:
Research Org.:
Univ. of Cincinnati, Dept. of Chemistry, OH (United States)
Sponsoring Org.:
USDOE Office of Energy Research, Washington, DC (United States)
OSTI Identifier:
329522
Report Number(s):
DOE/ER/60487-T1
ON: DE99002134; TRN: 99:004092
DOE Contract Number:  
FG02-86ER60487
Resource Type:
Technical Report
Resource Relation:
Other Information: PBD: 4 Aug 1998
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; PROGRESS REPORT; RADIOPHARMACEUTICALS; TECHNETIUM 99; ISOMERIC NUCLEI; IMAGE PROCESSING; NUCLEAR MEDICINE; ELECTROPHORESIS; MEASURING INSTRUMENTS; DESIGN

Citation Formats

Heineman, W R, and Seliskar, C J. Development of more efficacious Tc-99m organ imaging agents for use in nuclear medicine by characterization of radiopharmaceuticals. Final report, September 1, 1992--June 30, 1998. United States: N. p., 1998. Web. doi:10.2172/329522.
Heineman, W R, & Seliskar, C J. Development of more efficacious Tc-99m organ imaging agents for use in nuclear medicine by characterization of radiopharmaceuticals. Final report, September 1, 1992--June 30, 1998. United States. https://doi.org/10.2172/329522
Heineman, W R, and Seliskar, C J. 1998. "Development of more efficacious Tc-99m organ imaging agents for use in nuclear medicine by characterization of radiopharmaceuticals. Final report, September 1, 1992--June 30, 1998". United States. https://doi.org/10.2172/329522. https://www.osti.gov/servlets/purl/329522.
@article{osti_329522,
title = {Development of more efficacious Tc-99m organ imaging agents for use in nuclear medicine by characterization of radiopharmaceuticals. Final report, September 1, 1992--June 30, 1998},
author = {Heineman, W R and Seliskar, C J},
abstractNote = {The primary goals of this project were twofold: (1) Development of a microsensor that would demonstrate the capability for in vivo monitoring of a radiopharmaceutical after its injection into a test animal; and (2) Exploration of capillary electrophoresis (CE) as a separation technique for the analysis of radiopharmaceuticals that are mixtures of different compounds. The combination of in vivo sensors for real-time monitoring of specific chemical states of a radiopharmaceutical in individual organs and CE for analysis of radiopharmaceuticals prior to injection would provide valuable information regarding the fate of an imaging agent after administration. Such information should give insight into strategies for the development of more efficacious radiopharmaceuticals.},
doi = {10.2172/329522},
url = {https://www.osti.gov/biblio/329522}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Aug 04 00:00:00 EDT 1998},
month = {Tue Aug 04 00:00:00 EDT 1998}
}