Development of robotic plasma radiochemical assays for positron emission tomography
- Brookhaven National Lab., Upton, NY (United States). Dept. of Chemistry
A commercial laboratory robot system (Zymate PyTechnology II Laboratory Automation System; Zymark Corporation, Hopkinton, MA) was interfaced to standard and custom laboratory equipment and programmed to perform rapid radiochemical analyses for quantitative PET studies. A Zymark XP robot arm was used to carry out the determination of unchanged (parent) radiotracer in plasma using only solid phase extraction methods. Robotic throughput for the assay of parent radiotracer in plasma is 4--6 samples/hour depending on the radiotracer. Robotic assays of parent compound in plasma were validated for the radiotracers [{sup 11}C]Benztropine, [{sup 11}C]cocaine, [{sup 11}C]clorgyline, [{sup 11}C]deprenyl, [{sup 11}C]methadone, [{sup 11}C]methylphenidate, [{sup 11}C]raclorpride, and [{sup 11}C]SR46349B. A simple robot-assisted methods development strategy has been implemented to facilitate the automation of plasma assays of new radiotracers.
- Research Organization:
- Brookhaven National Lab. (BNL), Upton, NY (United States)
- Sponsoring Organization:
- USDOE, Washington, DC (United States); National Insts. of Health, Bethesda, MD (United States)
- DOE Contract Number:
- AC02-76CH00016
- OSTI ID:
- 171239
- Report Number(s):
- BNL-62384; CONF-9510260-1; ON: DE96003513; CNN: Grant NS-15380; TRN: 96:003676
- Resource Relation:
- Conference: International symposium of laboratory automation and robotics, Boston, MA (United States), 15-18 Oct 1995; Other Information: PBD: [1995]
- Country of Publication:
- United States
- Language:
- English
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