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Title: Microfluidic Tools for Biological Sample Preparation

Abstract

Researchers at Lawrence Livermore National Laboratory are developing means to collect and identify fluid-based biological pathogens in the forms of proteins, viruses, and bacteria. To support detection instruments, we are developing a flexible fluidic sample preparation unit. The overall goal of this Microfluidic Module is to input a fluid sample, containing background particulates and potentially target compounds, and deliver a processed sample for detection. We are developing techniques for sample purification, mixing, and filtration that would be useful to many applications including immunologic and nucleic acid assays. Sample preparation functions are accomplished with acoustic radiation pressure, dielectrophoresis, and solid phase extraction. We are integrating these technologies into packaged systems with pumps and valves to control fluid flow and investigating small-scale detection methods.

Authors:
; ; ; ; ; ; ;
Publication Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
15013423
Report Number(s):
UCRL-JC-147960
TRN: US200601%%387
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Conference
Resource Relation:
Conference: IEEE EMBS Special Topic Conference on Micro Technologies in Medicine and Biology, Madison, WI, May 02 - May 04, 2002
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; ACOUSTICS; BACTERIA; BIOLOGY; DETECTION; FILTRATION; FLUID FLOW; MEDICINE; NUCLEIC ACIDS; PARTICULATES; PATHOGENS; PROTEINS; PURIFICATION; RADIATION PRESSURE; SAMPLE PREPARATION; TARGETS; VALVES; VIRUSES

Citation Formats

Visuri, S R, Ness, K, Dzenitis, J, Benett, B, Bettencourt, K, Hamilton, J, Fisher, K, and Krulevitch, P. Microfluidic Tools for Biological Sample Preparation. United States: N. p., 2002. Web. doi:10.1109/MMB.2002.1002410.
Visuri, S R, Ness, K, Dzenitis, J, Benett, B, Bettencourt, K, Hamilton, J, Fisher, K, & Krulevitch, P. Microfluidic Tools for Biological Sample Preparation. United States. https://doi.org/10.1109/MMB.2002.1002410
Visuri, S R, Ness, K, Dzenitis, J, Benett, B, Bettencourt, K, Hamilton, J, Fisher, K, and Krulevitch, P. 2002. "Microfluidic Tools for Biological Sample Preparation". United States. https://doi.org/10.1109/MMB.2002.1002410. https://www.osti.gov/servlets/purl/15013423.
@article{osti_15013423,
title = {Microfluidic Tools for Biological Sample Preparation},
author = {Visuri, S R and Ness, K and Dzenitis, J and Benett, B and Bettencourt, K and Hamilton, J and Fisher, K and Krulevitch, P},
abstractNote = {Researchers at Lawrence Livermore National Laboratory are developing means to collect and identify fluid-based biological pathogens in the forms of proteins, viruses, and bacteria. To support detection instruments, we are developing a flexible fluidic sample preparation unit. The overall goal of this Microfluidic Module is to input a fluid sample, containing background particulates and potentially target compounds, and deliver a processed sample for detection. We are developing techniques for sample purification, mixing, and filtration that would be useful to many applications including immunologic and nucleic acid assays. Sample preparation functions are accomplished with acoustic radiation pressure, dielectrophoresis, and solid phase extraction. We are integrating these technologies into packaged systems with pumps and valves to control fluid flow and investigating small-scale detection methods.},
doi = {10.1109/MMB.2002.1002410},
url = {https://www.osti.gov/biblio/15013423}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Wed Apr 10 00:00:00 EDT 2002},
month = {Wed Apr 10 00:00:00 EDT 2002}
}

Conference:
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