skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: High throughput DNA damage quantification of human tissue with home-based collection device

Abstract

Kits, methods and systems for providing a service to provide a subject with information regarding the state of a subject's DNA damage. Collection, processing and analysis of samples are also described.

Inventors:
; ;
Publication Date:
Research Org.:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1433377
Patent Number(s):
9,931,634
Application Number:
14/634,266
Assignee:
The Regents of the University of California (Oakland, CA)
DOE Contract Number:  
AC02-05CH11231
Resource Type:
Patent
Resource Relation:
Patent File Date: 2015 Feb 27
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Costes, Sylvain V., Tang, Jonathan, and Yannone, Steven M. High throughput DNA damage quantification of human tissue with home-based collection device. United States: N. p., 2018. Web.
Costes, Sylvain V., Tang, Jonathan, & Yannone, Steven M. High throughput DNA damage quantification of human tissue with home-based collection device. United States.
Costes, Sylvain V., Tang, Jonathan, and Yannone, Steven M. 2018. "High throughput DNA damage quantification of human tissue with home-based collection device". United States. https://www.osti.gov/servlets/purl/1433377.
@article{osti_1433377,
title = {High throughput DNA damage quantification of human tissue with home-based collection device},
author = {Costes, Sylvain V. and Tang, Jonathan and Yannone, Steven M.},
abstractNote = {Kits, methods and systems for providing a service to provide a subject with information regarding the state of a subject's DNA damage. Collection, processing and analysis of samples are also described.},
doi = {},
url = {https://www.osti.gov/biblio/1433377}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Apr 03 00:00:00 EDT 2018},
month = {Tue Apr 03 00:00:00 EDT 2018}
}

Works referenced in this record:

Systems and methods for robotic transport
patent, August 2010


Cold emitter x-ray tube incorporating a nanostructured carbon film electron emitter
patent-application, January 2003


Specimen collecting, processing and analytical assembly
patent-application, October 2005


Reactor systems having a light-interacting component
patent-application, May 2007


Methods for Detecting DNA Damage and Screening for Cancer Therapeutics
patent-application, August 2007


System, Devices, and Methods for Bodily Fluid Sample Transport
patent-application, June 2014


Stabilization and Isolation of Extracellular Nucleic Acids
patent-application, August 2014


Devices and Methods for Determining Sensitivity to Radiation
patent-application, January 2015


Effect of Linear Energy Transfer (LET) on the Complexity of α-Particle-Induced Chromosome Aberrations in Human CD34+ Cells
journal, May 2007


M-FISH analysis shows that complex chromosome aberrations induced by α-particle tracks are cumulative products of localized rearrangements
journal, August 2002


Cellular responses to DNA double-strand breaks after low-dose γ-irradiation
journal, April 2009


Dynamics of DNA Double-Strand Breaks Revealed by Clustering of Damaged Chromosome Domains
journal, January 2004


DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
journal, January 2003


Histone H2AX phosphorylation in response to changes in chromatin structure induced by altered osmolarity
journal, November 2008


Estimating radiation-induced cancer risks at very low doses: rationale for using a linear no-threshold approach
journal, February 2006


Radial Cutoff LET and Radial Cutoff Dose Calculations for Heavy Charged Particles in Water
journal, June 1973


Double-Strand Breaks in Heterochromatin Move Outside of a Dynamic HP1a Domain to Complete Recombinational Repair
journal, March 2011


DNA-repair protein distribution along the tracks of energetic ions
journal, November 2006


DNA double-strand breaks in heterochromatin elicit fast repair protein recruitment, histone H2AX phosphorylation and relocation to euchromatin
journal, April 2011


Live cell microscopy analysis of radiation-induced DNA double-strand break motion
journal, February 2009


Repair of Radiation-Induced Heat-Labile Sites is Independent of DNA-PKcs, XRCC1 and PARP
journal, May 2008


Comparison of the induction and disappearance of DNA double strand breaks and γ-H2AX foci after irradiation of chromosomes in G1-phase or in condensed metaphase cells
journal, March 2008


Induction and quantification of γ-H2AX foci following low and high LET-irradiation
journal, January 2006


Expression of phosphorylated histone H2AX in cultured cell lines following exposure to X‐rays
journal, May 2003


Radiation chemistry of heavy-particle tracks. 1. General considerations
journal, December 1980


Computational modelling of low-energy electron-induced DNA damage by early physical and chemical events
journal, January 1997


Extraction of spots in biological images using multiscale products
journal, September 2002


Stochastic properties of radiation-induced DSB: DSB distributions in large scale chromatin loops, the HPRT gene and within the visible volumes of DNA repair foci
journal, January 2008


A portable microfluidic fluorescence spectrometer device for γ-H2AX-based biological dosimetry
journal, September 2011


DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139
journal, March 1998


Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses
journal, April 2003


Review: Proximity effects in the production of chromosome aberrations by ionizing radiation
journal, January 1997


Microfluidic Isolation of Leukocytes from Whole Blood for Phenotype and Gene Expression Analysis
journal, August 2006


Radiological Physics Characteristics of the Extracted Heavy Ion Beams of the Bevatron
journal, December 1971


Inter-individual variation in DNA double-strand break repair in human fibroblasts before and after exposure to low doses of ionizing radiation
journal, January 2010


Spatiotemporal characterization of ionizing radiation induced DNA damage foci and their relation to chromatin organization
journal, April 2010


Image-Based Modeling Reveals Dynamic Redistribution of DNA Damage into Nuclear Sub-Domains
journal, January 2007


Colocalization of multiple DNA double-strand breaks at a single Rad52 repair centre
journal, May 2003


Evidence for formation of DNA repair centers and dose-response nonlinearity in human cells
journal, December 2011


Reflections and meditations upon complex chromosomal exchanges
journal, December 2002