Biosensors engineered from conditionally stable ligand-binding domains
Patent
·
OSTI ID:1393435
Disclosed is a biosensor engineered to conditionally respond to the presence of specific small molecules, the biosensors including conditionally stable ligand-binding domains (LBDs) which respond to the presence of specific small molecules, wherein readout of binding is provided by reporter genes or transcription factors (TFs) fused to the LBDs.
- Research Organization:
- Harvard Univ., Cambridge, MA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- FG02-02ER63445
- Assignee:
- President and Fellows of Harvard College (Cambridge, MA); University of Washington (Seattle, WA)
- Patent Number(s):
- 9,766,255
- Application Number:
- 14/993,509
- OSTI ID:
- 1393435
- Resource Relation:
- Patent File Date: 2016 Jan 12
- Country of Publication:
- United States
- Language:
- English
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