System and method for measuring fluorescence of a sample

Riot, Vincent J.

Title: System and method for measuring fluorescence of a sample

Patent · Tue Jun 27 00:00:00 EDT 2017

OSTI ID:1366507

Riot, Vincent J.

The present disclosure provides a system and a method for measuring fluorescence of a sample. The sample may be a polymerase-chain-reaction (PCR) array, a loop-mediated-isothermal amplification array, etc. LEDs are used to excite the sample, and a photodiode is used to collect the sample's fluorescence. An electronic offset signal is used to reduce the effects of background fluorescence and the noises from the measurement system. An integrator integrates the difference between the output of the photodiode and the electronic offset signal over a given period of time. The resulting integral is then converted into digital domain for further processing and storage.

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Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC52-07NA27344

Assignee:: Lawrence Livermore National Security, LLC

Patent Number(s):: 9,689,799

Application Number:: 14/602,076

OSTI ID:: 1366507

Resource Relation:: Patent File Date: 2015 Jan 21

Country of Publication:: United States

Language:: English

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