Wireless Monitoring of Liver Hemodynamics In Vivo
- Texas A & M Univ., College Station, TX (United States). Dept. of Biomedical Engineering
- Univ. of Pittsburgh, PA (United States). Dept. of Surgery; Veterans Affairs Healthcare System, Pittsburgh, PA (United States)
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- Univ. of California, Irvine, CA (United States)
Liver transplants have their highest failure rate in the first two weeks following surgery. There are no devices for continuous, real-time monitoring of the graft, currently. Here, we present a continuous perfusion and oxygen consumption monitor based on photoplethysmography. The sensor is battery operated and communicates wirelessly with a data acquisition computer which provides the possibility of implantation provided sufficient miniaturization. In two in vivo porcine studies, the sensor tracked perfusion changes in hepatic tissue during vascular occlusions with a root mean square error (RMSE) of 0.125 mL/min/g of tissue. We show the possibility of using the pulsatile wave to measure the arterial oxygen saturation similar to pulse oximetry. This signal is used as a feedback to extract the venous oxygen saturation from the DC levels. Arterial and venous oxygen saturation changes were measured with an RMSE of 2.19 and 1.39% respectively when no vascular occlusions were induced. The resulting error increased to 2.82 and 3.83% when vascular occlusions were induced during hypoxia. These errors are similar to the resolution of the oximetry catheter used as a reference. This work is the first realization of a wireless perfusion and oxygenation sensor for continuous monitoring of hepatic perfusion and oxygenation changes.
- Research Organization:
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
- Sponsoring Organization:
- National Institutes of Health (NIH)
- Grant/Contract Number:
- AC05-00OR22725; #5R01-GM077150
- OSTI ID:
- 1366361
- Journal Information:
- PLoS ONE, Vol. 9, Issue 7; ISSN 1932-6203
- Publisher:
- Public Library of ScienceCopyright Statement
- Country of Publication:
- United States
- Language:
- English
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