Computational approaches to substrate-based cell motility

Ziebert, Falko; Aranson, Igor S.

doi:10.1038/npjcompumats.2016.19

Title: Computational approaches to substrate-based cell motility

Journal Article · Fri Jul 15 00:00:00 EDT 2016 · npj Computational Materials

DOI:https://doi.org/10.1038/npjcompumats.2016.19· OSTI ID:1352532

Ziebert, Falko ^[1]; Aranson, Igor S. ^[2]

Albert-Ludwigs-Univ. Freiburg, Freiburg (Germany); Institut Charles Sadron, Strasbourg (France)
Argonne National Lab. (ANL), Argonne, IL (United States); Northwestern Univ., Evanston, IL (United States)

Substrate-based crawling motility of eukaryotic cells is essential for many biological functions, both in developing and mature organisms. Motility dysfunctions are involved in several life-threatening pathologies such as cancer and metastasis. Motile cells are also a natural realization of active, self-propelled ‘particles’, a popular research topic in nonequilibrium physics. Finally, from the materials perspective, assemblies of motile cells and evolving tissues constitute a class of adaptive self-healing materials that respond to the topography, elasticity, and surface chemistry of the environment and react to external stimuli. Although a comprehensive understanding of substrate-based cell motility remains elusive, progress has been achieved recently in its modeling on the whole cell level. Furthermore we survey the most recent advances in computational approaches to cell movement and demonstrate how these models improve our understanding of complex self-organized systems such as living cells.

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Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES); Materials Sciences and Engineering Division; German Science Foundation

Grant/Contract Number:: AC02-06CH11357

OSTI ID:: 1352532

Journal Information:: npj Computational Materials, Vol. 2; ISSN 2057-3960

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 49 works

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