Arabidopsis ribosomal proteins control vacuole trafficking and developmental programs through the regulation of lipid metabolism

Li, Ruixi; Sun, Ruobai; Hicks, Glenn R.; Raikhel, Natasha V.

doi:10.1073/pnas.1422656112

Title: Arabidopsis ribosomal proteins control vacuole trafficking and developmental programs through the regulation of lipid metabolism

Journal Article · Mon Dec 22 00:00:00 EST 2014 · Proceedings of the National Academy of Sciences of the United States of America

DOI:https://doi.org/10.1073/pnas.1422656112· OSTI ID:1348363

Li, Ruixi ^[1]; Sun, Ruobai ^[1]; Hicks, Glenn R. ^[1]; Raikhel, Natasha V. ^[1]

Univ. of California, Riverside, CA (United States). Dept. of Botany and Plant Sciences. Center for Plant Cell Biology. Inst. for Integrative Genome Biology

The vacuole is the most prominent compartment in plant cells and is important for ion and protein storage. In our effort to search for key regulators in the plant vacuole sorting pathway, ribosomal large subunit 4 (rpl4d) was identified as a translational mutant defective in both vacuole trafficking and normal development. Polysome profiling of the rpl4d mutant showed reduction in polysome-bound mRNA compared with wild-type, but no significant change in the general mRNA distribution pattern. Ribsomal profiling data indicated that genes in the lipid metabolism pathways were translationally down-regulated in the rpl4d mutant. Live imaging studies by Nile red staining suggested that both polar and nonpolar lipid accumulation was reduced in meristem tissues of rpl4d mutants. Pharmacological evidence showed that sterol and sphingolipid biosynthetic inhibitors can phenocopy the defects of the rpl4d mutant, including an altered vacuole trafficking pattern. Genetic evidence from lipid biosynthetic mutants indicates that alteration in the metabolism of either sterol or sphingolipid biosynthesis resulted in vacuole trafficking defects, similar to the rpl4d mutant. Tissue-specific complementation with key enzymes from lipid biosynthesis pathways can partially rescue both vacuole trafficking and auxin-related developmental defects in the rpl4d mutant. These results indicate that lipid metabolism modulates auxin-mediated tissue differentiation and endomembrane trafficking pathways downstream of ribosomal protein function.

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Research Organization:: Univ. of California, Riverside, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES); National Science Foundation (NSF); National Inst. of Health (NIH) (United States); Kansas Technology Enterprise Corporation (United States); Kansas State Univ. (United States)

Grant/Contract Number:: FG02-02ER15295; EPS 0236913; MCB 0455318; DBI 0521587; P20RR16475

OSTI ID:: 1348363

Journal Information:: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, Issue 1; ISSN 0027-8424

Publisher:: National Academy of Sciences, Washington, DC (United States)Copyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 28 works

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