Protein dynamics in a broad frequency range: Dielectric spectroscopy studies

Nakanishi, Masahiro; Sokolov, Alexei P.

doi:10.1016/j.jnoncrysol.2014.08.057

Title: Protein dynamics in a broad frequency range: Dielectric spectroscopy studies

Journal Article · Wed Sep 17 00:00:00 EDT 2014 · Journal of Non-Crystalline Solids

DOI:https://doi.org/10.1016/j.jnoncrysol.2014.08.057· OSTI ID:1347310

Nakanishi, Masahiro ^[1]; Sokolov, Alexei P. ^[2]

Hebrew Univ. of Jerusalem (Israel)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Tennessee, Knoxville, TN (United States)

We present detailed dielectric spectroscopy studies of dynamics in two hydrated proteins, lysozyme and myoglobin. We emphasize the importance of explicit account for possible Maxwell-Wagner (MW) polarization effects in protein powder samples. Combining our data with earlier literature results, we demonstrate the existence of three major relaxation processes in globular proteins. To understand the mechanisms of these relaxations we involve literature data on neutron scattering, simulations and NMR studies. The faster process is ascribed to coupled protein-hydration water motions and has relaxation time similar to 10-50 Ps at room temperature. The intermediate process is similar to 10(2)-10(3) times slower than the faster process and might be strongly affected by MW polarizations. Based on the analysis of data obtained by different experimental techniques and simulations, we ascribe this process to large scale domain-like motions of proteins. The slowest observed process is similar to 10(6)-10(7) times slower than the faster process and has anomalously large dielectric amplitude Delta epsilon similar to 10(2)-10(4). The microscopic nature of this process is not clear, but it seems to be related to the glass transition of hydrated proteins. The presentedresults suggest a general classification of the relaxation processes in hydrated proteins. (c) 2014 Elsevier B.V. All rights reserved.

View Accepted Manuscript (DOE)

Cite

Export

Save

Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1347310

Journal Information:: Journal of Non-Crystalline Solids, Vol. 407, Issue C; ISSN 0022-3093

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

Citation Metrics:

Cited by: 53 works

Citation information provided by
Web of Science

References (79)

Dynamical transition of myoglobin revealed by inelastic neutron scattering Doster, Wolfgang; Cusack, Stephen; Petry, Winfried Nature, Vol. 337, Issue 6209 https://doi.org/10.1038/337754a0	journal	February 1989
Dynamic personalities of proteins Henzler-Wildman, Katherine; Kern, Dorothee Nature, Vol. 450, Issue 7172 https://doi.org/10.1038/nature06522	journal	December 2007
Structural Determinants of Protein Dynamics: Analysis of 15N NMR Relaxation Measurements for Main-Chain and Side-Chain Nuclei of Hen Egg White Lysozyme Buck, Matthias; Boyd, Jonathan; Redfield, Christina Biochemistry, Vol. 34, Issue 12 https://doi.org/10.1021/bi00012a023	journal	March 1995
Solid-state NMR and protein dynamics Krushelnitsky, Alexey; Reichert, Detlef Progress in Nuclear Magnetic Resonance Spectroscopy, Vol. 47, Issue 1-2 https://doi.org/10.1016/j.pnmrs.2005.04.001	journal	October 2005
Dynamics at the Protein-Water Interface from 17O Spin Relaxation in Deeply Supercooled Solutions Mattea, Carlos; Qvist, Johan; Halle, Bertil Biophysical Journal, Vol. 95, Issue 6 https://doi.org/10.1529/biophysj.108.135194	journal	September 2008
Dynamics of Protein and Peptide Hydration Modig, Kristofer; Liepinsh, Edvards; Otting, Gottfried Journal of the American Chemical Society, Vol. 126, Issue 1 https://doi.org/10.1021/ja038325d	journal	January 2004
Observation of fragile-to-strong dynamic crossover in protein hydration water Chen, S. -H.; Liu, L.; Fratini, E. Proceedings of the National Academy of Sciences, Vol. 103, Issue 24 https://doi.org/10.1073/pnas.0602474103	journal	June 2006
The origin of the dynamic transition in proteins Khodadadi, S.; Pawlus, S.; Roh, J. H. The Journal of Chemical Physics, Vol. 128, Issue 19 https://doi.org/10.1063/1.2927871	journal	May 2008
Influence of Hydration on Protein Dynamics: Combining Dielectric and Neutron Scattering Spectroscopy Data Khodadadi, S.; Pawlus, S.; Sokolov, A. P. The Journal of Physical Chemistry B, Vol. 112, Issue 45 https://doi.org/10.1021/jp8059807	journal	November 2008
Three Classes of Motion in the Dynamic Neutron-Scattering Susceptibility of a Globular Protein Hong, Liang; Smolin, Nikolai; Lindner, Benjamin Physical Review Letters, Vol. 107, Issue 14 https://doi.org/10.1103/PhysRevLett.107.148102	journal	September 2011
Surface Hydration Amplifies Single-Well Protein Atom Diffusion Propagating into the Macromolecular Core Hong, Liang; Cheng, Xiaolin; Glass, Dennis C. Physical Review Letters, Vol. 108, Issue 23 https://doi.org/10.1103/PhysRevLett.108.238102	journal	June 2012
Nanosecond Relaxation Dynamics of Hydrated Proteins: Water versus Protein Contributions Khodadadi, S.; Curtis, J. E.; Sokolov, A. P. The Journal of Physical Chemistry B, Vol. 115, Issue 19 https://doi.org/10.1021/jp1122213	journal	May 2011
Magnitude and Molecular Origin of Water Slowdown Next to a Protein Sterpone, Fabio; Stirnemann, Guillaume; Laage, Damien Journal of the American Chemical Society, Vol. 134, Issue 9 https://doi.org/10.1021/ja3007897	journal	February 2012
Dielectric Relaxation Spectroscopy of Lysozyme Aqueous Solutions: Analysis of the δ-Dispersion and the Contribution of the Hydration Water Cametti, C.; Marchetti, S.; Gambi, C. M. C. The Journal of Physical Chemistry B, Vol. 115, Issue 21 https://doi.org/10.1021/jp2019389	journal	June 2011
Protein and Water Dynamics in Bovine Serum Albumin–Water Mixtures over Wide Ranges of Composition Panagopoulou, A.; Kyritsis, A.; Shinyashiki, N. The Journal of Physical Chemistry B, Vol. 116, Issue 15 https://doi.org/10.1021/jp2105727	journal	April 2012
Glass Transitions in Aqueous Solutions of Protein (Bovine Serum Albumin) Shinyashiki, Naoki; Yamamoto, Wataru; Yokoyama, Ayame The Journal of Physical Chemistry B, Vol. 113, Issue 43 https://doi.org/10.1021/jp905511w	journal	October 2009
Microwave dielectric study on bound water of globule proteins in aqueous solution Miura, Nobuhiro; Asaka, Nobuyuki; Shinyashiki, Naoki Biopolymers, Vol. 34, Issue 3 https://doi.org/10.1002/bip.360340307	journal	March 1994
What Can Really Be Learned from Dielectric Spectroscopy of Protein Solutions? A Case Study of Ribonuclease A Oleinikova, A.; Sasisanker, P.; Weingärtner, H. The Journal of Physical Chemistry B, Vol. 108, Issue 24 https://doi.org/10.1021/jp049618b	journal	May 2004
Relaxation dynamics of a protein solution investigated by dielectric spectroscopy Wolf, M.; Gulich, R.; Lunkenheimer, P. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Vol. 1824, Issue 5 https://doi.org/10.1016/j.bbapap.2012.02.008	journal	May 2012
Hydration Study of Globular Proteins by Microwave Dielectric Spectroscopy Yokoyama, Keiichi; Kamei, Takashi; Minami, Hiroshi The Journal of Physical Chemistry B, Vol. 105, Issue 50 https://doi.org/10.1021/jp011217y	journal	December 2001
Protein-Water Interactions Determined by Dielectric Methods Pethig, R. Annual Review of Physical Chemistry, Vol. 43, Issue 1 https://doi.org/10.1146/annurev.pc.43.100192.001141	journal	October 1992
Thermodynamics of protein denaturation. Effect of pressure on the denaturation on ribonuclease A Brandts, John F.; Oliveira, Robert J.; Westort, Chester Biochemistry, Vol. 9, Issue 4 https://doi.org/10.1021/bi00806a045	journal	February 1970
Reversible pressure-temperature denaturation of chymotrypsinogen Hawley, S. A. Biochemistry, Vol. 10, Issue 13 https://doi.org/10.1021/bi00789a002	journal	June 1971
Response of native and denatured hen lysozyme to high pressure studied by ¹⁵ N/ ¹ H NMR spectroscopy: Native and denatured lysozyme at high pressure Kamatari, Yuji O.; Yamada, Hiroaki; Akasaka, Kazuyuki European Journal of Biochemistry, Vol. 268, Issue 6 https://doi.org/10.1046/j.1432-1327.2001.02050.x	journal	March 2001
Pressure denaturation of metmyoglobin Zipp, Adam; Kauzmann, Walter Biochemistry, Vol. 12, Issue 21 https://doi.org/10.1021/bi00745a028	journal	October 1973
Solvent content of protein crystals Matthews, B. W. Journal of Molecular Biology, Vol. 33, Issue 2 https://doi.org/10.1016/0022-2836(68)90205-2	journal	April 1968
Hydration of macromolecules. III. Hydration of polypeptides Kuntz, Irwin D. Journal of the American Chemical Society, Vol. 93, Issue 2 https://doi.org/10.1021/ja00731a036	journal	January 1971
The interpretation of protein structures: Total volume, group volume distributions and packing density Richards, Frederic M. Journal of Molecular Biology, Vol. 82, Issue 1 https://doi.org/10.1016/0022-2836(74)90570-1	journal	January 1974
Compressibility of globular proteins in water at 25.degree.C Gekko, Kunihiko.; Noguchi, Hajime. The Journal of Physical Chemistry, Vol. 83, Issue 21 https://doi.org/10.1021/j100484a006	journal	October 1979
Compressibility-structure relationship of globular proteins Gekko, Kunihiko; Hasegawa, Yasunobu Biochemistry, Vol. 25, Issue 21 https://doi.org/10.1021/bi00369a034	journal	October 1986
Protein Hydration Investigations with High-Frequency Dielectric Spectroscopy Wei, Yan-Zhen; Kumbharkhane, A. C.; Sadeghi, M. The Journal of Physical Chemistry, Vol. 98, Issue 26 https://doi.org/10.1021/j100077a034	journal	June 1994
Accuracy of molecular mass determination of proteins in solution by small-angle X-ray scattering Mylonas, Efstratios; Svergun, Dmitri I. Journal of Applied Crystallography, Vol. 40, Issue s1 https://doi.org/10.1107/S002188980700252X	journal	February 2007
Improving the Density of Jammed Disordered Packings Using Ellipsoids Donev, A. Science, Vol. 303, Issue 5660 https://doi.org/10.1126/science.1093010	journal	February 2004
Physics of the Granular State Jaeger, H. M.; Nagel, S. R. Science, Vol. 255, Issue 5051 https://doi.org/10.1126/science.255.5051.1523	journal	March 1992
A Three-Dimensional Model of the Myoglobin Molecule Obtained by X-Ray Analysis Kendrew, J. C.; Bodo, G.; Dintzis, H. M. Nature, Vol. 181, Issue 4610, p. 662-666 https://doi.org/10.1038/181662a0	journal	March 1958
Structure of Hen Egg-White Lysozyme: A Three-dimensional Fourier Synthesis at 2 Å Resolution Blake, C. C. F.; Koenig, D. F.; Mair, G. A. Nature, Vol. 206, Issue 4986 https://doi.org/10.1038/206757a0	journal	May 1965
Broadband complex permittivity measurement techniques of materials with thin configuration at microwave frequencies Murata, Ken-ichiro; Hanawa, Akio; Nozaki, Ryusuke Journal of Applied Physics, Vol. 98, Issue 8 https://doi.org/10.1063/1.2115099	journal	October 2005
Insulated electrodes for eliminating conductivity in dielectric relaxation experiments Richert, R. The European Physical Journal B, Vol. 68, Issue 2 https://doi.org/10.1140/epjb/e2009-00084-8	journal	March 2009
Appearance of a Debye process at the conductivity relaxation frequency of a viscous liquid Richert, Ranko; Agapov, Alexander; Sokolov, Alexei P. The Journal of Chemical Physics, Vol. 134, Issue 10 https://doi.org/10.1063/1.3565481	journal	March 2011
Analysis of complex dielectric spectra. I. One-dimensional derivative techniques and three-dimensional modelling Wübbenhorst, Michael; van Turnhout, Jan Journal of Non-Crystalline Solids, Vol. 305, Issue 1-3 https://doi.org/10.1016/S0022-3093(02)01086-4	journal	July 2002
Dispersion and Absorption in Dielectrics I. Alternating Current Characteristics Cole, Kenneth S.; Cole, Robert H. The Journal of Chemical Physics, Vol. 9, Issue 4 https://doi.org/10.1063/1.1750906	journal	April 1941
Dielectric Relaxation in Glycerol, Propylene Glycol, and n ‐Propanol Davidson, D. W.; Cole, R. H. The Journal of Chemical Physics, Vol. 19, Issue 12 https://doi.org/10.1063/1.1748105	journal	December 1951
A complex plane representation of dielectric and mechanical relaxation processes in some polymers Havriliak, S.; Negami, S. Polymer, Vol. 8 https://doi.org/10.1016/0032-3861(67)90021-3	journal	January 1967
The dielectric response of simple organic glass formers Kudlik, A.; Benkhof, S.; Blochowicz, T. Journal of Molecular Structure, Vol. 479, Issue 2-3 https://doi.org/10.1016/S0022-2860(98)00871-0	journal	April 1999
Fast and slow relaxation processes in glasses Wiedersich, J.; Blochowicz, T.; Benkhof, S. Journal of Physics: Condensed Matter, Vol. 11, Issue 10A https://doi.org/10.1088/0953-8984/11/10A/010	journal	January 1999
Excess Wing in the Dielectric Loss of Glass Formers: A Johari-Goldstein $β$ Relaxation? Schneider, U.; Brand, R.; Lunkenheimer, P. Physical Review Letters, Vol. 84, Issue 24 https://doi.org/10.1103/PhysRevLett.84.5560	journal	June 2000
Excess wing in the dielectric loss of glass formers: further evidence for a β-relaxation Lunkenheimer, P.; Wehn, R.; Riegger, Th Journal of Non-Crystalline Solids, Vol. 307-310 https://doi.org/10.1016/S0022-3093(02)01493-X	journal	September 2002
An extended coupling model description of the evolution of dynamics with time in supercooled liquids and ionic conductors Ngai, K. L. Journal of Physics: Condensed Matter, Vol. 15, Issue 11 https://doi.org/10.1088/0953-8984/15/11/332	journal	March 2003
Energy landscape in molecular glasses probed by high-resolution dielectric experiments Gainaru, Catalin; Böhmer, Roland; Kahlau, Robert Physical Review B, Vol. 82, Issue 10 https://doi.org/10.1103/PhysRevB.82.104205	journal	September 2010
No fragile-to-strong crossover in LiCl-H ₂ O solution Nakanishi, Masahiro; Griffin, Philip; Mamontov, Eugene The Journal of Chemical Physics, Vol. 136, Issue 12 https://doi.org/10.1063/1.3697841	journal	March 2012
The protein glass transition as measured by dielectric spectroscopy and differential scanning calorimetry Jansson, H.; Swenson, J. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Vol. 1804, Issue 1 https://doi.org/10.1016/j.bbapap.2009.06.026	journal	January 2010
Properties of hydration water and its role in protein dynamics Swenson, Jan; Jansson, Helén; Hedström, Johan Journal of Physics: Condensed Matter, Vol. 19, Issue 20 https://doi.org/10.1088/0953-8984/19/20/205109	journal	April 2007
Universal features of water dynamics in solutions of hydrophilic polymers, biopolymers, and small glass-forming materials Cerveny, Silvina; Alegría, Ángel; Colmenero, Juan Physical Review E, Vol. 77, Issue 3 https://doi.org/10.1103/PhysRevE.77.031803	journal	March 2008
The Johari−Goldstein β-Relaxation of Water Capaccioli, S.; Ngai, K. L.; Shinyashiki, N. The Journal of Physical Chemistry B, Vol. 111, Issue 28 https://doi.org/10.1021/jp071857m	journal	July 2007
Resolving the ambiguity of the dynamics of water and clarifying its role in hydrated proteins Ngai, K. L.; Capaccioli, S.; Ancherbak, S. Philosophical Magazine, Vol. 91, Issue 13-15 https://doi.org/10.1080/14786435.2010.523716	journal	May 2011
A broad glass transition in hydrated proteins Khodadadi, S.; Malkovskiy, A.; Kisliuk, A. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Vol. 1804, Issue 1 https://doi.org/10.1016/j.bbapap.2009.05.006	journal	January 2010
Influence of Hydration on the Dynamics of Lysozyme Roh, J. H.; Curtis, J. E.; Azzam, S. Biophysical Journal, Vol. 91, Issue 7 https://doi.org/10.1529/biophysj.106.082214	journal	October 2006
Dynamics in Protein Powders on the Nanosecond–Picosecond Time Scale Are Dominated by Localized Motions Nickels, Jonathan D.; García Sakai, Victoria; Sokolov, Alexei P. The Journal of Physical Chemistry B, Vol. 117, Issue 39 https://doi.org/10.1021/jp4058884	journal	September 2013
Dynamics of Protein and its Hydration Water: Neutron Scattering Studies on Fully Deuterated GFP Nickels, Jonathan D.; O’Neill, Hugh; Hong, Liang Biophysical Journal, Vol. 103, Issue 7 https://doi.org/10.1016/j.bpj.2012.08.046	journal	October 2012
The protein-solvent glass transition Doster, Wolfgang Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Vol. 1804, Issue 1 https://doi.org/10.1016/j.bbapap.2009.06.019	journal	January 2010
Change of caged dynamics at T _g in hydrated proteins: Trend of mean squared displacements after correcting for the methyl-group rotation contribution Ngai, K. L.; Capaccioli, S.; Paciaroni, A. The Journal of Chemical Physics, Vol. 138, Issue 23 https://doi.org/10.1063/1.4810752	journal	June 2013
Glassy dynamics and enzymatic activity of lysozyme Pizzitutti, F.; Bruni, F. Physical Review E, Vol. 64, Issue 5 https://doi.org/10.1103/PhysRevE.64.052905	journal	October 2001
Dielectric Relaxations in Confined Hydrated Myoglobin Schirò, Giorgio; Cupane, Antonio; Vitrano, Eugenio The Journal of Physical Chemistry B, Vol. 113, Issue 28 https://doi.org/10.1021/jp901420r	journal	July 2009
The dielectric properties of ice Ih in the range 272–133 K Johari, G. P.; Whalley, E. The Journal of Chemical Physics, Vol. 75, Issue 3 https://doi.org/10.1063/1.442139	journal	August 1981
Large Domain Fluctuations on 50-ns Timescale Enable Catalytic Activity in Phosphoglycerate Kinase Inoue, R.; Biehl, R.; Rosenkranz, T. Biophysical Journal, Vol. 99, Issue 7 https://doi.org/10.1016/j.bpj.2010.08.017	journal	October 2010
Neutron Spin-Echo Studies of Hemoglobin and Myoglobin: Multiscale Internal Dynamics Lal, Jyotsana; Fouquet, Peter; Maccarini, Marco Journal of Molecular Biology, Vol. 397, Issue 2 https://doi.org/10.1016/j.jmb.2010.01.029	journal	March 2010
Functional Domain Motions in Proteins on the ∼1–100 ns Timescale: Comparison of Neutron Spin-Echo Spectroscopy of Phosphoglycerate Kinase with Molecular-Dynamics Simulation Smolin, N.; Biehl, R.; Kneller, G. R. Biophysical Journal, Vol. 102, Issue 5 https://doi.org/10.1016/j.bpj.2012.01.002	journal	March 2012
Low-Temperature Heat Capacity and Glassy Behavior of Lysozyme Crystal ^† Miyazaki, Yuji; Matsuo, Takasuke; Suga, Hiroshi The Journal of Physical Chemistry B, Vol. 104, Issue 33 https://doi.org/10.1021/jp0007686	journal	August 2000
Thermal properties of water in myoglobin crystals and solutions at subzero temperatures Doster, W.; Bachleitner, A.; Dunau, R. Biophysical Journal, Vol. 50, Issue 2 https://doi.org/10.1016/S0006-3495(86)83455-5	journal	August 1986
Vibrational frequency shifts as a probe of hydrogen bonds: thermal expansion and glass transition of myoglobin in mixed solvents Demmel, F.; Doster, W.; Petry, W. European Biophysics Journal, Vol. 26, Issue 4 https://doi.org/10.1007/s002490050087	journal	September 1997
Dynamics of Biological Macromolecules: Not a Simple Slaving by Hydration Water Khodadadi, S.; Roh, J. H.; Kisliuk, A. Biophysical Journal, Vol. 98, Issue 7 https://doi.org/10.1016/j.bpj.2009.12.4284	journal	April 2010
Viscoelastic properties of protein crystals: Triclinic crystals of hen egg white lysozyme in different conditions Morozov, V. N.; Morozova, T. Ya. Biopolymers, Vol. 20, Issue 3 https://doi.org/10.1002/bip.1981.360200304	journal	March 1981
Glass transition and dynamics in BSA–water mixtures over wide ranges of composition studied by thermal and dielectric techniques Panagopoulou, A.; Kyritsis, A.; Sabater i. Serra, R. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Vol. 1814, Issue 12 https://doi.org/10.1016/j.bbapap.2011.07.014	journal	December 2011
Relaxation Processes in Supercooled Confined Water and Implications for Protein Dynamics Swenson, Jan; Jansson, Helén; Bergman, Rikard Physical Review Letters, Vol. 96, Issue 24 https://doi.org/10.1103/PhysRevLett.96.247802	journal	June 2006
Relaxation in liquids, polymers and plastic crystals — strong/fragile patterns and problems Angell, C. A. Journal of Non-Crystalline Solids, Vol. 131-133 https://doi.org/10.1016/0022-3093(91)90266-9	journal	June 1991
The protein-glass analogy: New insight from homopeptide comparisons Green, J. L.; Fan, J.; Angell, C. A. The Journal of Physical Chemistry, Vol. 98, Issue 51 https://doi.org/10.1021/j100102a052	journal	December 1994
Resolving the controversy on the glass transition temperature of water? Capaccioli, S.; Ngai, K. L. The Journal of Chemical Physics, Vol. 135, Issue 10 https://doi.org/10.1063/1.3633242	journal	September 2011
Atomic-Level Characterization of the Structural Dynamics of Proteins Shaw, D. E.; Maragakis, P.; Lindorff-Larsen, K. Science, Vol. 330, Issue 6002 https://doi.org/10.1126/science.1187409	journal	October 2010
Ferroelectric Hydration Shells around Proteins: Electrostatics of the Protein−Water Interface LeBard, David N.; Matyushov, Dmitry V. The Journal of Physical Chemistry B, Vol. 114, Issue 28 https://doi.org/10.1021/jp1006999	journal	June 2010

Cited By (7)

Terahertz-infrared spectroscopy of Shewanella oneidensis MR-1 extracellular matrix Gagkaeva, Z. V.; Zhukova, E. S.; Grinenko, V. Journal of Biological Physics, Vol. 44, Issue 3 https://doi.org/10.1007/s10867-018-9497-4	journal	May 2018
Enhancement of discharged energy density of poly(ethylene oxide) by soy protein isolate: ARTICLE Rashidi, Soheil; Zheng, Zhuoyuan; Li, Bin Journal of Applied Polymer Science, Vol. 134, Issue 34 https://doi.org/10.1002/app.45214	journal	May 2017
Water in the hydrated protein powders: Dynamic and structure Sasaki, Kaito; Popov, Ivan; Feldman, Yuri The Journal of Chemical Physics, Vol. 150, Issue 20 https://doi.org/10.1063/1.5096881	journal	May 2019
Confined water dynamics in a hydrated photosynthetic pigment–protein complex Kurzweil-Segev, Yael; Popov, Ivan; Eisenberg, Ido Phys. Chem. Chem. Phys., Vol. 19, Issue 41 https://doi.org/10.1039/c7cp05417c	journal	January 2017
The JG β -relaxation in water and impact on the dynamics of aqueous mixtures and hydrated biomolecules Capaccioli, S.; Ngai, K. L.; Ancherbak, S. The Journal of Chemical Physics, Vol. 151, Issue 3 https://doi.org/10.1063/1.5100835	journal	July 2019
Dynamics of proteins in solution Grimaldo, Marco; Roosen-Runge, Felix; Zhang, Fajun Quarterly Reviews of Biophysics, Vol. 52 https://doi.org/10.1017/s0033583519000027	journal	January 2019
Molecular Dynamics of Functional Azide-Containing Acrylic Films Carsí, Marta; Sanchis, Maria; Vallejos, Saul Polymers, Vol. 10, Issue 8 https://doi.org/10.3390/polym10080859	journal	August 2018

Similar Records

Dynamics of a globular protein and its hydration water studied by neutron scattering and MD simulations

Journal Article · Fri Jan 01 00:00:00 EST 2010 · Spectroscopy · OSTI ID:1347310

Chen, Sow-Hsin; Lagi, Marco; Chu, Xiang-qiang; +5 more

Atomistic details of protein dynamics and the role of hydration water

Journal Article · Wed May 04 00:00:00 EDT 2016 · Biochimica et Biophysica Acta - General Subjects · OSTI ID:1347310

Khodadadi, Sheila; Sokolov, Alexei P.

Nanosecond Relaxation Dynamics of Hydrated Proteins: Water versus protein contributions

Journal Article · Sat Jan 01 00:00:00 EST 2011 · Journal of Physical Chemistry B · OSTI ID:1347310

Khodadadi, S; Curtis, J. E.; Sokolov, Alexei P

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Protein dynamics
Hydration water
Glass transition
Dielectric spectroscopy
Lysozyme
Myoglobin
EGG-WHITE LYSOZYME
GOLDSTEIN BETA-RELAXATION
BOVINE SERUM-ALBUMIN
NEUTRON SPIN-ECHO
GLOBULAR-PROTEINS
HYDRATION WATER
GLASS FORMERS
PHOSPHOGLYCERATE K

Title: Protein dynamics in a broad frequency range: Dielectric spectroscopy studies

Citation Formats

References (79)

Cited By (7)

Similar Records

Related Subjects