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Title: Positron emission tomography probe to monitor selected sugar metabolism in vivo

Patent ·
OSTI ID:1346982

The invention disclosed herein discloses selected ribose isomers that are useful as PET probes (e.g. [18F]-2-fluoro-2-deoxy-arabinose). These PET probes are useful, for example, in methods designed to monitor physiological processes including ribose metabolism and/or to selectively observe certain tissue/organs in vivo. The invention disclosed herein further provides methods for making and using such probes.

Research Organization:
Univ. of California, Oakland, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
SC0001249
Assignee:
The Regents of the University of California
Patent Number(s):
9,592,309
Application Number:
14/399,701
OSTI ID:
1346982
Resource Relation:
Patent File Date: 2013 May 09
Country of Publication:
United States
Language:
English

References (3)

Synthesis of 2′-Deoxy-2′-Fluoro- 1-Β- D -Arabinofuranosyl Uracil Derivatives: A Method Suitable For Preparation of [18F]-Labeled Nucleosides journal August 2002
Autoradiolysis of the 2-deoxy-2-[18F]fluoro-D-glucose radiopharmaceutical journal May 2005
Biodistribution and PET imaging of [18F]-fluoroadenosine derivatives journal April 2007

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