Production of isotopes using high power proton beams

Nolen, Jr., Jerry A.; Gomes, Itacil C.

Title: Production of isotopes using high power proton beams

Patent · Tue Dec 01 00:00:00 EST 2015

OSTI ID:1345367

Nolen, Jr., Jerry A.; Gomes, Itacil C.

The invention provides for a method for producing isotopes using a beam of particles from an accelerator, whereby the beam is maintained at between about 70 to 2000 MeV; and contacting a thorium-containing target with the particles. The medically important isotope .sup.225Ac is produced via the nuclear reaction (p,2p6n), whereby an energetic proton causes the ejection of 2 protons and 6 neutrons from a .sup.232Th target nucleus. Another medically important isotope .sup.213Bi is then available as a decay product. The production of highly purified .sup.211At is also provided.

View Patent

Cite

Export

Save

Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC02-06CH11357

Assignee:: UCHICAGO ARGONNE, LLC (Chicago, IL)

Patent Number(s):: 9,202,602

Application Number:: 13/025,079

OSTI ID:: 1345367

Resource Relation:: Patent File Date: 2011 Feb 10

Country of Publication:: United States

Language:: English

References (22)

Separation of Actinium and Thorium from Uranium and Its Daughters Swanson, Donald H. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/3434809 US Patent Document 3434809	patent	March 1969
Target arrangement for spallation-neutron-sources Bauer, Gunter https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4582667 US Patent Document 4,582,667	patent	April 1986
Method for the simultaneous preparation of Radon-211, Xenon-125, Xenon-123, Astatine-211, Iodine-125 and Iodine-123 Mirzadeh, Saed; Lambrecht, Richard M. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4664869 US Patent Document 4,664,869	patent	May 1987
Process for producing astatine-211 for radiopharmaceutical use Mirzadeh, Saed; Lambrecht, Richard M. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4681727 US Patent Document 4,681,727	patent	July 1987
Aqueous liquid bleaching detergents which are stable during storage and washing process Carron, Henry; Jourdan-Laforte, Eric https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5160656 US Patent Document 5,160,656	patent	November 1992
Method for producing actinium-225 and bismuth-213 van Geel, Jacobus N. C.; Fuger, Jean J.; Koch, Lothar https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5355394 US Patent Document 5,355,394	patent	October 1994
Process and apparatus for the production of BI-213 cations Horwitz, E. Philip; Hines, John J.; Chiarizia, Renato https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5854968 US Patent Document 5,854,968	patent	December 1998
Transmutable radiotherapy device Sioshansi, Piran; Bricault, Raymond J. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6293899 US Patent Document 6,293,899	patent	September 2001
Method for producing Ac-225 by irradiation of Ra-226 with protons Apostolidis, Christos; Janssens, Willem; Koch, Lothar https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6299666 US Patent Document 6,299,666	patent	October 2001
Actinium-225 complexes and conjugates for targeted radiotherapy Frank, R. Keith; Kiefer, Garry E.; Simon, Jaime https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6670456 US Patent Document 6,670,456	patent	December 2003
Method of producing Actinium-225 and daughters Satz, Stanley; Schenter, Scott https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6680993 US Patent Document 6,680,993	patent	January 2004
Spallation device for producing neutrons Ritter, Guillaume https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6895064 US Patent Document 6,895,064	patent	May 2005
Radiotherapy Larsen, Roy H.; Henriksen, Gjermund https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7056275 US Patent Document 7,056,275	patent	June 2006
Actinium radioisotope products of enhanced purity Meikrantz, David H.; Todd, Terry A.; Tranter, Troy J. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7736610 US Patent Document 7,736,610	patent	June 2010
Multicolumn selectivity inversion generator for production of high purity actinium for use in therapeutic nuclear medicine Bond, Andrew H.; Horwitz, E. Philip; McAlister, Daniel R. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20030194364 US Patent Application 10/261031; 20030194364	patent-application	October 2002
Method for Production of Radioisotope Preparations and Their Use in Life Science, Research, Medical Application and Industry Ravn, Helge Leif; Beyer, Gerd Juergen; Koester, Ulli https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090162278 US Patent Application 11/814035; 20090162278	patent-application	June 2009
Spallation of Uranium and Thorium Nuclei with Bev-Energy Protons Pate, B. D.; Poskanzer, A. M. Physical Review, Vol. 123, Issue 2 https://doi.org/10.1103/PhysRev.123.647	journal	July 1961
Production of ²²⁵Ac and ²²³Ra by irradiation of Th with accelerated protons Zhuikov, B. L.; Kalmykov, S. N.; Ermolaev, S. V. Radiochemistry, Vol. 53, Issue 1, p. 73-80 https://doi.org/10.1134/S1066362211010103	journal	February 2011
Production of Ac-225 from Th-229 for Targeted α Therapy Apostolidis, C.; Molinet, R.; Rasmussen, G. Analytical Chemistry, Vol. 77, Issue 19 https://doi.org/10.1021/ac0580114	journal	October 2005
Targeted Killing of Virally Infected Cells by Radiolabeled Antibodies to Viral Proteins Dadachova, Ekaterina; Patel, Mahesh C.; Toussi, Sima PLoS Medicine, Vol. 3, Issue 11 https://doi.org/10.1371/journal.pmed.0030427	journal	November 2006
Targeted α-particle radiotherapy with ²¹¹At-labeled monoclonal antibodies Zalutsky, Michael R.; Reardon, David A.; Pozzi, Oscar R. Nuclear Medicine and Biology, Vol. 34, Issue 7, p. 779-785 https://doi.org/10.1016/j.nucmedbio.2007.03.007	journal	October 2007
Cancer Therapy with Alpha-Emitters Labeled Peptides Dadachova, Ekaterina Seminars in Nuclear Medicine, Vol. 40, Issue 3 https://doi.org/10.1053/j.semnuclmed.2010.01.002	journal	May 2010

Similar Records

Production of isotopes using high power proton beams

Patent · Tue Apr 02 00:00:00 EDT 2019 · OSTI ID:1345367

Nolen, Jr., Jerry A.; Gomes, Itacil C.

A CYCLOTRON CONCEPT TO SUPPORT ISOTOPE PRODUCTION FOR SCIENCE AND MEDICAL APPLICATIONS

Conference · Tue Jan 01 00:00:00 EST 2013 · OSTI ID:1345367

Egle, Brian; Mirzadeh, Saed; Tatum, B Alan; +7 more

TRASH TO TREASURE: CONVERTING COLD WAR LEGACY WASTE INTO WEAPONS AGAINST CANCER

Conference · Wed Oct 06 00:00:00 EDT 2004 · OSTI ID:1345367

Nicholas, R G; Lacy, N H; Butz, T R; +1 more

Related Subjects

43 PARTICLE ACCELERATORS

Title: Production of isotopes using high power proton beams

Citation Formats

References (22)

Similar Records

Related Subjects