Identification and use of genes encoding amatoxin and phallotoxin

Hallen, Heather E.; Walton, Jonathan D.; Luo, Hong; Scott-Craig, John S.

Title: Identification and use of genes encoding amatoxin and phallotoxin

Patent · Tue Dec 13 00:00:00 EST 2016

OSTI ID:1335867

Hallen, Heather E.; Walton, Jonathan D.; Luo, Hong; Scott-Craig, John S.

The present invention relates to compositions and methods comprising genes and peptides associated with cyclic peptide toxins and toxin production in mushrooms. In particular, the present invention relates to using genes and proteins from Amanita species encoding Amanita peptides, specifically relating to amatoxins and phallotoxins. In a preferred embodiment, the present invention also relates to methods for detecting Amanita peptide toxin genes for identifying Amanita peptide-producing mushrooms and for diagnosing suspected cases of mushroom poisoning. Further, the present inventions relate to providing kits for diagnosing and monitoring suspected cases of mushroom poisoning in patients.

View Patent

Cite

Export

Save

Research Organization:: Michigan State Univ., East Lansing, MI (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: FG02-91ER20021

Assignee:: Board of Trustees of Michigan State University (East Lansing

Patent Number(s):: 9,518,097

Application Number:: 12/268,229

OSTI ID:: 1335867

Resource Relation:: Patent File Date: 2008 Nov 10

Country of Publication:: United States

Language:: English

References (12)

Process for amplifying, detecting, and/or-cloning nucleic acid sequences Mullis, Kary B.; Erlich, Henry A.; Arnheim, Norman https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4683195 US Patent Document 4,683,195	patent	July 1987
Process for amplifying nucleic acid sequences Mullis, Kary B. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4683202 US Patent Document 4,683,202	patent	July 1987
Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme Mullis, Kary B.; Erlich, Henry A.; Gelfand, David H. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4965188 US Patent Document 4,965,188	patent	October 1990
Process for direct sequencing during template amplification Koster, Hubert; Van Den Boom, Dirk Johannes; Ruppert, Andreas https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5928906 US Patent Document 5,928,906	patent	July 1999
Use of Galerina marginata genes and proteins for peptide production Hallen-Adams, Heather E.; Scott-Craig, John S.; Walton, Jonathan D. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/9273100 US Patent Document 9,273,100	patent	March 2016
Diagnostic Detection of Nucleic Acids Urnovitz, Howard B. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20010014445 US Patent Application 08/943607; 20010014445	patent-application	August 2001
Random-primed reverse transcriptase-in vitro transcription method for rna amplification Ziman, Michael; Davis, Collen P. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20040081978 US Patent Application 10/432176; 20040081978	patent-application	April 2004
Methods for amplifying polymeric nucleic acids Behlke, Mark A.; Walder, Joseph A.; Manthey, Jeffrey A. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20050255486 US Patent Application 10/911652; 20050255486	patent-application	November 2005
Polymorphic markers and methods of genotyping corn Wu, Kunsheng https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20060141495 US Patent Application 11/218305; 20060141495	patent-application	June 2006
Nucleic Acid Sample Purification and Enrichment with a Thermo-Affinity Microfluidic Sub-Circuit Yershov, Gennadiy M.; Kukhtin, Alexander; Chernov, Boris K. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20080076677 US Patent Application 11/744112; 20080076677	patent-application	March 2008
Annotated Plant Genes Kovalic, David; Liu, Jingdong https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090093620 US Patent Application 09/684016; 20090093620	patent-application	April 2009
Use Of Galerina Marginata Genes And Proteins For Peptide Production Hallen-Adams, Heather E.; Scott-Craig, John S.; Walton, Jonathan D. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20120276588 US Patent Application 13/362561; 20120276588	patent-application	November 2012

Similar Records

Profiling of Amatoxins and Phallotoxins in the Genus Lepiota by Liquid Chromatography Combined with UV Absorbance and Mass Spectrometry

Journal Article · Fri Aug 01 00:00:00 EDT 2014 · Toxins · OSTI ID:1335867

Sgambelluri, R.; Epis, Sara; Sassera, Davide; +3 more

Use of Galerina marginata genes and proteins for peptide production

Patent · Tue Mar 01 00:00:00 EST 2016 · OSTI ID:1335867

Hallen-Adams, Heather E.; Scott-Craig, John S.; Walton, Jonathan D.; +1 more

Use of galerina marginata genes and proteins for peptide production

Patent · Tue Apr 03 00:00:00 EDT 2018 · OSTI ID:1335867

Hallen-Adams, Heather E.; Scott-Craig, John S.; Walton, Jonathan D.; +1 more

Related Subjects

59 BASIC BIOLOGICAL SCIENCES

Title: Identification and use of genes encoding amatoxin and phallotoxin

Citation Formats

References (12)

Similar Records

Related Subjects