Enhanced dynamics of hydrated tRNA on nanodiamond surfaces: A combined neutron scattering and MD simulation study

Dhindsa, Gurpreet K.; Bhowmik, Debsindhu; Goswami, Monojoy; O’Neill, Hugh; Mamontov, Eugene; Sumpter, Bobby G.; Hong, Liang; Ganesh, Panchapakesan; Chu, Xiang -qiang

doi:10.1021/acs.jpcb.6b07511

Title: Enhanced dynamics of hydrated tRNA on nanodiamond surfaces: A combined neutron scattering and MD simulation study

Journal Article · Thu Sep 01 00:00:00 EDT 2016 · Journal of Physical Chemistry. B, Condensed Matter, Materials, Surfaces, Interfaces and Biophysical Chemistry

DOI:https://doi.org/10.1021/acs.jpcb.6b07511· OSTI ID:1329113

Dhindsa, Gurpreet K. ^[1]; Bhowmik, Debsindhu ^[1]; Goswami, Monojoy ^[2]; O’Neill, Hugh ^[2]; Mamontov, Eugene ^[2]; Sumpter, Bobby G. ^[2]; Hong, Liang ^[3]; Ganesh, Panchapakesan ^[2]; Chu, Xiang -qiang ^[1]

Wayne State Univ., Detroit, MI (United States)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Shanghai Jiao Tong Univ., Shanghai (China)

Nontoxic, biocompatible nanodiamonds (ND) have recently been implemented in rational, systematic design of optimal therapeutic use in nanomedicines. However, hydrophilicity of the ND surface strongly influences structure and dynamics of biomolecules that restrict in situ applications of ND. Therefore, fundamental understanding of the impact of hydrophilic ND surface on biomolecules at the molecular level is essential. For tRNA, we observe an enhancement of dynamical behavior in the presence of ND contrary to generally observed slow motion at strongly interacting interfaces. We took advantage of neutron scattering experiments and computer simulations to demonstrate this atypical faster dynamics of tRNA on ND surface. The strong attractive interactions between ND, tRNA, and water give rise to unlike dynamical behavior and structural changes of tRNA in front of ND compared to without ND. As a result, our new findings may provide new design principles for safer, improved drug delivery platforms.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States). Oak Ridge Leadership Computing Facility (OLCF); Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States). Center for Nanophase Materials Sciences (CNMS); Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States). Spallation Neutron Source (SNS)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1329113

Journal Information:: Journal of Physical Chemistry. B, Condensed Matter, Materials, Surfaces, Interfaces and Biophysical Chemistry, Vol. 120, Issue 38; ISSN 1520-6106

Publisher:: American Chemical SocietyCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 10 works

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