Self-Assembling Biological Springs Force Transducers on the Micron Nanoscale
- Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)
In this project, we are developing a new system for measuring forces within and between nanoscale biological molecules based on mesoscopic springs made of cholesterol helical ribbons. These ribbons self-assemble in a wide variety of complex fluids containing sterol, a mixture of surfactants and water [1] and have spring constants in the range from 0.5 to 500 pN/nm [2-4]. By the end of this project, we have demonstrated that the cholesterol helical ribbons can be used for measuring forces between biological objects and for mapping the strain fields in hydrogels.
- Research Organization:
- Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)
- Sponsoring Organization:
- USDOE Chicago Operations Office (CO)
- DOE Contract Number:
- FG02-04ER46149
- OSTI ID:
- 1299203
- Country of Publication:
- United States
- Language:
- English
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