Viral kinetic modeling: state of the art

Canini, Laetitia; Perelson, Alan S.

doi:10.1007/s10928-014-9363-3

Title: Viral kinetic modeling: state of the art

Journal Article · Wed Jun 25 00:00:00 EDT 2014 · Journal of Pharmacokinetics and Pharmacodynamics

DOI:https://doi.org/10.1007/s10928-014-9363-3· OSTI ID:1282052

Canini, Laetitia ^[1]; Perelson, Alan S. ^[1]

Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Theoretical Biology and Biophysics

Viral kinetic modeling has led to increased understanding of the within host dynamics of viral infections and the effects of therapy. Here we review recent developments in the modeling of viral infection kinetics with emphasis on two infectious diseases: hepatitis C and influenza. We review how viral kinetic modeling has evolved from simple models of viral infections treated with a drug or drug cocktail with an assumed constant effectiveness to models that incorporate drug pharmacokinetics and pharmacodynamics, as well as phenomenological models that simply assume drugs have time varying-effectiveness. We also discuss multiscale models that include intracellular events in viral replication, models of drug-resistance, models that include innate and adaptive immune responses and models that incorporate cell-to-cell spread of infection. Overall, viral kinetic modeling has provided new insights into the understanding of the disease progression and the modes of action of several drugs. In conclusion, we expect that viral kinetic modeling will be increasingly used in the coming years to optimize drug regimens in order to improve therapeutic outcomes and treatment tolerability for infectious diseases.

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Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: USDOE; National Institutes of Health (NIH)

Grant/Contract Number:: AC52-06NA25396; R01-AI028433; P20-GM10345; R01-AI078881; R34-HL109334; R01-OD011095

OSTI ID:: 1282052

Journal Information:: Journal of Pharmacokinetics and Pharmacodynamics, Vol. 41, Issue 5; ISSN 1567-567X

Publisher:: SpringerCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 58 works

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