skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Elasticity and Inverse Temperature Transition in Elastin

Journal Article · · Journal of Physical Chemistry Letters
 [1];  [2];  [3];  [2];  [1]
  1. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Tennessee, Knoxville, TN (United States)
  2. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
  3. Julich Research Centre (Germany). Julich Centre for Neutron Science (JCNS); Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
+ Show Author Affiliations

Structurally, elastin is protein and biomaterial that provides elasticity and resilience to a range of tissues. This work provides insights into the elastic properties of elastin and its peculiar inverse temperature transition (ITT). These features are dependent on hydration of elastin and are driven by a similar mechanism of hydrophobic collapse to an entropically favorable state. Moreover, when using neutron scattering, we quantify the changes in the geometry of molecular motions above and below the transition temperature, showing a reduction in the displacement of water-induced motions upon hydrophobic collapse at the ITT. Finally, we measured the collective vibrations of elastin gels as a function of elongation, revealing no changes in the spectral features associated with local rigidity and secondary structure, in agreement with the entropic origin of elasticity.

Research Organization:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States). Spallation Neutron Source (SNS)
Sponsoring Organization:
USDOE Office of Science (SC), Basic Energy Sciences (BES)
Grant/Contract Number:
AC05-00OR22725
OSTI ID:
1265833
Journal Information:
Journal of Physical Chemistry Letters, Vol. 6, Issue 20; ISSN 1948-7185
Publisher:
American Chemical SocietyCopyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 13 works
Citation information provided by
Web of Science

References (57)

Rigidity, Secondary Structure, and the Universality of the Boson Peak in Proteins journal June 2014
Thermoelasticity of swollen elastin networks at constant composition journal April 1980
Elastin Structure, Biosynthesis, and Relation to Disease States journal March 1981
Low-Temperature Protein Dynamics:  A Simulation Analysis of Interprotein Vibrations and the Boson Peak at 150 K journal February 2006
The secondary structure and architecture of human elastin journal December 1998
The elastic properties of elastin journal April 1974
Cross-linked open-pore elastic hydrogels based on tropoelastin, elastin and high pressure CO2 journal March 2010
Shape of tropoelastin, the highly extensible protein that controls human tissue elasticity journal February 2011
Dynamics of Protein and its Hydration Water: Neutron Scattering Studies on Fully Deuterated GFP journal October 2012
FT-Raman spectroscopic study of thoracic aortic wall subjected to uniaxial stress: FT-Raman spectroscopic study of thoracic aortic wall journal December 2009
Coacervation Characteristics of Recombinant Human Tropoelastin journal November 1997
Rigidity of poly- L -glutamic acid scaffolds: Influence of secondary and supramolecular structure : RIGIDITY OF PGA SCAFFOLDS journal March 2015
Silkworm Silk under Tensile Strain Investigated by Synchrotron X-ray Diffraction and Neutron Spectroscopy journal February 2007
Water-coupled low-frequency modes of myoglobin and lysozyme observed by inelastic neutron scattering journal November 1997
Hydrogen bonding in globular proteins journal January 1984
Dynamics in Protein Powders on the Nanosecond–Picosecond Time Scale Are Dominated by Localized Motions journal September 2013
Domain 26 of Tropoelastin Plays a Dominant Role in Association by Coacervation journal September 2000
Dynamical transition of myoglobin revealed by inelastic neutron scattering journal February 1989
A librational entropy mechanism for elastomers with repeating peptide sequences in helical array journal March 1983
Effects of solvent damping on side chain and backbone contributions to the protein boson peak journal July 2001
On the accumulation of d-aspartate in elastin and other proteins of the ageing aorta journal December 1992
Direct Evidence of the Amino Acid Side Chain and Backbone Contributions to Protein Anharmonicity journal February 2010
Conformation and interactions of elastin. Proton magnetic resonance of the repeating pentapeptide journal January 1974
Painting biological low-frequency vibrational modes from small peptides to proteins journal January 2015
The molecular basis for the inverse temperature transition of elastin11Edited by A. R. Fersht journal January 2001
The Low-Temperature Inflection Observed in Neutron Scattering Measurements of Proteins Is Due to Methyl Rotation: Direct Evidence Using Isotope Labeling and Molecular Dynamics Simulations journal April 2010
Bovine Elastin and κ-Elastin Secondary Structure Determination by Optical Spectroscopies journal November 1995
Elastic and Conformational Softness of a Globular Protein journal January 2013
Engineered Tropoelastin and Elastin-Based Biomaterials book January 2009
Secondary structure and rigidity in model proteins journal January 2013
The Physical Properties of Elastic Tissue book January 1976
Physical Chemistry of Biological Free Energy Transduction As Demonstrated by Elastic Protein-Based Polymers † journal December 1997
Protein-solvent Interactions. R.B. Gregory. Marcel Dekker, Inc., New York, 1994. xix + 570 pp. $185.00. ISBN 0-8247-9239-4 journal January 1996
Extracellular matrix 4: The elastic fiber journal October 1993
Protein–water displacement distributions journal June 2005
Crosslinked α-elastin biomaterials: towards a processable elastin mimetic scaffold journal March 2005
Influence of Hydration on the Dynamics of Lysozyme journal October 2006
New Molecular Model for the Long-range Elasticity of Elastin journal August 1970
Elastin as a self–organizing biomaterial: use of recombinantly expressed human elastin polypeptides as a model for investigations of structure and self–assembly of elastin
  • Keeley, F. W.; Bellingham, C. M.; Woodhouse, K. A.
  • Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, Vol. 357, Issue 1418 https://doi.org/10.1098/rstb.2001.1027
journal February 2002
Elastic proteins: biological roles and mechanical properties
  • Gosline, J.; Lillie, M.; Carrington, E.
  • Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, Vol. 357, Issue 1418 https://doi.org/10.1098/rstb.2001.1022
journal February 2002
Dynamics and Rigidity in an Intrinsically Disordered Protein, β-Casein journal June 2014
Coherent Neutron Scattering and Collective Dynamics in the Protein, GFP journal November 2013
Stress-Induced Modification of the Boson Peak Scaling Behavior journal November 2013
Development of a linear helical conformation from its cyclic correlate. β-Spiral model of the elastin poly(pentapeptide) (VPGVG)n journal September 1981
Spectroscopic evidence revealing polyproline II structure in hydrophobic, putatively elastomeric sequences encoded by specific exons of human tropoelastin: PPII Structure in Elastomeric Sequences in Human Exons journal January 2004
Elastin book January 2005
Hydrophobic Hydration Is an Important Source of Elasticity in Elastin-Based Biopolymers journal December 2001
The Elastic Properties of Elastin 1,2 journal December 1958
Temperature-correlated force and structure development in elastomeric polypeptides: The Ile1 analog of the polypentapeptide of elastin journal October 1986
Dynamics of tRNA at Different Levels of Hydration journal April 2009
Short elastin-like peptides exhibit the same temperature-induced structural transitions as elastin polymers: implications for protein engineering journal October 1998
Molecular Machines: How Motion and Other Functions of Living Organisms Can Result from Reversible Chemical Changes journal June 1993
Onsets of Anharmonicity in Protein Dynamics journal July 2005
Internal molecular motions of bacteriorhodopsin: hydration-induced flexibility studied by quasielastic incoherent neutron scattering using oriented purple membranes. journal July 1996
Entropic Elasticity Controls Nanomechanics of Single Tropocollagen Molecules journal July 2007
Biochemistry of tropoelastin journal November 1998
Primary structures of bovine elastin a, b, and c deduced from the sequences of cDNA clones. journal April 1987

Cited By (3)

Temperature induced conformational changes in the elastin-like peptide GVG(VPGVG) 3 journal January 2019
The Liquid Structure of Elastin journal December 2016
Strain-dependent fractional molecular diffusion in humid spider silk fibres journal September 2016

Similar Records

On the source of entropic elastomeric force in polypeptides and proteins: Backbone configurational vs. side-chain solvational entropy
Conference · Sun Jan 01 00:00:00 EST 1989 · International Journal of Quantum Chemistry; (USA) · OSTI ID:1265833
+1 more
Solvent deuteration enhancement of hydrophobicity: DSC study of the inverse temperature transition of elastin-based polypeptides
Journal Article · Thu Oct 03 00:00:00 EDT 1991 · Journal of Physical Chemistry; (United States) · OSTI ID:1265833
Temperature-dependent morphology of hybrid nanoflowers from elastin-like polypeptides
Journal Article · Sat Feb 01 00:00:00 EST 2014 · APL Materials · OSTI ID:1265833
+2 more

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
36 MATERIALS SCIENCE
ELP
entropy
hydrophobic hydration
low-frequency vibrations
neutron scattering