Scattering from phase-separated vesicles. I. An analytical form factor for multiple static domains

Heberle, Frederick A.; Anghel, Vinicius N. P.; Katsaras, John

doi:10.1107/S160057671501362X

Title: Scattering from phase-separated vesicles. I. An analytical form factor for multiple static domains

Journal Article · Tue Aug 18 00:00:00 EDT 2015 · Journal of Applied Crystallography (Online)

DOI:https://doi.org/10.1107/S160057671501362X· OSTI ID:1265605

Heberle, Frederick A. ^[1]; Anghel, Vinicius N. P. ^[2]; Katsaras, John ^[3]

Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Biology and Soft Matter Division
Canadian Nuclear Lab., Chalk River, ON (Canada)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Biology and Soft Matter Division; Univ. of Tennessee, Knoxville, TN (United States). Dept. of Physics and Astronomy; Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Joint Inst. for Neutron Sciences; Brock Univ., St. Catharines, ON (Canada). Dept. of Physics

This is the first in a series of studies considering elastic scattering from laterally heterogeneous lipid vesicles containing multiple domains. Unique among biophysical tools, small-angle neutron scattering can in principle give detailed information about the size, shape and spatial arrangement of domains. A general theory for scattering from laterally heterogeneous vesicles is presented, and the analytical form factor for static domains with arbitrary spatial configuration is derived, including a simplification for uniformly sized round domains. The validity of the model, including series truncation effects, is assessed by comparison with simulated data obtained from a Monte Carlo method. Several aspects of the analytical solution for scattering intensity are discussed in the context of small-angle neutron scattering data, including the effect of varying domain size and number, as well as solvent contrast. Finally, the analysis indicates that effects of domain formation are most pronounced when the vesicle's average scattering length density matches that of the surrounding solvent.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1265605

Journal Information:: Journal of Applied Crystallography (Online), Vol. 48, Issue 5; ISSN 1600-5767

Publisher:: International Union of CrystallographyCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 12 works

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References (54)

Scattering from laterally heterogeneous vesicles. II. The form factor Anghel, Vinicius N. P.; Kučerka, Norbert; Pencer, Jeremy Journal of Applied Crystallography, Vol. 40, Issue 3 https://doi.org/10.1107/S002188980701206X	journal	May 2007
Theory of dynamic light scattering from polydisperse systems Aragón, S. R. The Journal of Chemical Physics, Vol. 64, Issue 6 https://doi.org/10.1063/1.432528	journal	January 1976
Lipid Peroxides Promote Large Rafts: Effects of Excitation of Probes in Fluorescence Microscopy and Electrochemical Reactions during Vesicle Formation Ayuyan, Artem G.; Cohen, Fredric S. Biophysical Journal, Vol. 91, Issue 6 https://doi.org/10.1529/biophysj.106.087387	journal	September 2006
A neutron scattering study of the structure of a bimodal colloidal crystal Bartlett, P.; Ottewill, R. H. The Journal of Chemical Physics, Vol. 96, Issue 4 https://doi.org/10.1063/1.461926	journal	February 1992
Imaging coexisting fluid domains in biomembrane models coupling curvature and line tension Baumgart, Tobias; Hess, Samuel T.; Webb, Watt W. Nature, Vol. 425, Issue 6960 https://doi.org/10.1038/nature02013	journal	October 2003
X-ray scattering from unilamellar lipid vesicles Brzustowicz, Michael R.; Brunger, Axel T. Journal of Applied Crystallography, Vol. 38, Issue 1 https://doi.org/10.1107/S0021889804029206	journal	January 2005
Phase diagrams and lipid domains in multicomponent lipid bilayer mixtures Feigenson, Gerald W. Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1788, Issue 1 https://doi.org/10.1016/j.bbamem.2008.08.014	journal	January 2009
Structure Analysis by Small-Angle X-Ray and Neutron Scattering Feigin, L. A.; Svergun, D. I. https://doi.org/10.1007/978-1-4757-6624-0	book	January 1987
Toward a Better Raft Model: Modulated Phases in the Four-Component Bilayer, DSPC/DOPC/POPC/CHOL Goh, Shih Lin; Amazon, Jonathan J.; Feigenson, Gerald W. Biophysical Journal, Vol. 104, Issue 4 https://doi.org/10.1016/j.bpj.2013.01.003	journal	February 2013
Structure of tomato bushy stunt virus Harrison, Stephen C. Journal of Molecular Biology, Vol. 42, Issue 3 https://doi.org/10.1016/0022-2836(69)90236-8	journal	June 1969
Hybrid and Nonhybrid Lipids Exert Common Effects on Membrane Raft Size and Morphology Heberle, Frederick A.; Doktorova, Milka; Goh, Shih Lin Journal of the American Chemical Society, Vol. 135, Issue 40 https://doi.org/10.1021/ja407624c	journal	September 2013
Model-based approaches for the determination of lipid bilayer structure from small-angle neutron and X-ray scattering data Heberle, Frederick A.; Pan, Jianjun; Standaert, Robert F. European Biophysics Journal, Vol. 41, Issue 10 https://doi.org/10.1007/s00249-012-0817-5	journal	May 2012
Bilayer Thickness Mismatch Controls Domain Size in Model Membranes Heberle, Frederick A.; Petruzielo, Robin S.; Pan, Jianjun Journal of the American Chemical Society, Vol. 135, Issue 18 https://doi.org/10.1021/ja3113615	journal	February 2013
Comparison of Three Ternary Lipid Bilayer Mixtures: FRET and ESR Reveal Nanodomains Heberle, Frederick A.; Wu, Jing; Goh, Shih Lin Biophysical Journal, Vol. 99, Issue 10 https://doi.org/10.1016/j.bpj.2010.09.064	journal	November 2010
Monte Carlo modeling of small-angle scattering data from non-interacting homogeneous and heterogeneous particles in solution Henderson, S. J. Biophysical Journal, Vol. 70, Issue 4 https://doi.org/10.1016/S0006-3495(96)79725-4	journal	April 1996
Lipid segregation and IgE receptor signaling: A decade of progress Holowka, David; Gosse, Julie A.; Hammond, Adam T. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Vol. 1746, Issue 3 https://doi.org/10.1016/j.bbamcr.2005.06.007	journal	December 2005
Model of separated form factors for unilamellar vesicles Kiselev, M. A.; Lesieur, P.; Kisselev, A. M. Applied Physics A: Materials Science & Processing, Vol. 74, Issue 0 https://doi.org/10.1007/s003390201837	journal	December 2002
Small-angle neutron scattering of aqueous dispersions of lipids and lipid mixtures. A contrast variation study Knoll, W.; Haas, J.; Stuhrmann, H. B. Journal of Applied Crystallography, Vol. 14, Issue 3 https://doi.org/10.1107/S0021889881009102	journal	June 1981
Small-angle neutron scattering study of lipid phase diagrams by the contrast variation method Knoll, Wolfgang; Ibel, Konrad; Sackmann, Erich Biochemistry, Vol. 20, Issue 22 https://doi.org/10.1021/bi00525a015	journal	October 1981
The inverse contrast variation in small-angle neutron scattering: a sensitive technique for the evaluation of lipid phase diagrams Knoll, W.; Schmidt, G.; Ibel, K. Journal of Applied Crystallography, Vol. 18, Issue 2 https://doi.org/10.1107/S0021889885009840	journal	April 1985
Small-angle neutron scattering study of lateral phase separation in dimyristoylphosphatidylcholine-cholesterol mixed membranes Knoll, W.; Schmidt, G.; Ibel, K. Biochemistry, Vol. 24, Issue 19 https://doi.org/10.1021/bi00340a043	journal	September 1985
Lateral order in binary lipid alloys and its coupling to membrane functions Knoll, W.; Schmidt, G.; Rötzer, H. Chemistry and Physics of Lipids, Vol. 57, Issue 2-3 https://doi.org/10.1016/0009-3084(91)90086-Q	journal	March 1991
Critical demixing in fluid bilayers of phospholipid mixtures. A neutron diffraction study Knoll, Wolfgang; Schmidt, Günther; Sackmann, Erich The Journal of Chemical Physics, Vol. 79, Issue 7 https://doi.org/10.1063/1.446193	journal	October 1983
Control of a Nanoscopic-to-Macroscopic Transition: Modulated Phases in Four-Component DSPC/DOPC/POPC/Chol Giant Unilamellar Vesicles Konyakhina, Tatyana M.; Goh, Shih Lin; Amazon, Jonathan Biophysical Journal, Vol. 101, Issue 2 https://doi.org/10.1016/j.bpj.2011.06.019	journal	July 2011
Phase diagram of a 4-component lipid mixture: DSPC/DOPC/POPC/chol Konyakhina, Tatyana M.; Wu, Jing; Mastroianni, James D. Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1828, Issue 9 https://doi.org/10.1016/j.bbamem.2013.05.020	journal	September 2013
Analysis of small angle neutron scattering spectra from polydisperse interacting colloids Kotlarchyk, Michael; Chen, Sow‐Hsin The Journal of Chemical Physics, Vol. 79, Issue 5 https://doi.org/10.1063/1.446055	journal	September 1983
Curvature Effect on the Structure of Phospholipid Bilayers Kučerka, Norbert; Pencer, Jeremy; Sachs, Jonathan N. Langmuir, Vol. 23, Issue 3 https://doi.org/10.1021/la062455t	journal	January 2007
Do Lipid Rafts Exist? Leslie, M. Science, Vol. 334, Issue 6059 https://doi.org/10.1126/science.334.6059.1046-b	journal	November 2011
Lipid Rafts As a Membrane-Organizing Principle Lingwood, D.; Simons, K. Science, Vol. 327, Issue 5961 https://doi.org/10.1126/science.1174621	journal	December 2009
Cholesterol-induced fluid membrane domains: A compendium of lipid-raft ternary phase diagrams Marsh, Derek Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1788, Issue 10 https://doi.org/10.1016/j.bbamem.2009.08.004	journal	October 2009
Nano-meter-sized domain formation in lipid membranes observed by small angle neutron scattering Masui, T.; Urakami, N.; Imai, M. The European Physical Journal E, Vol. 27, Issue 4 https://doi.org/10.1140/epje/i2008-10400-x	journal	December 2008
Membrane lipids: where they are and how they behave van Meer, Gerrit; Voelker, Dennis R.; Feigenson, Gerald W. Nature Reviews Molecular Cell Biology, Vol. 9, Issue 2 https://doi.org/10.1038/nrm2330	journal	February 2008
Small-scale composition fluctuations and microdomain formation in lipid raft models as revealed by small-angle neutron scattering Nicolini, Chiara; Thiyagarajan, Pappannan; Winter, Roland Physical Chemistry Chemical Physics, Vol. 6, Issue 24 https://doi.org/10.1039/b408928f	journal	January 2004
Relationships between plasma membrane microdomains and HIV-1 assembly Ono, Akira Biology of the Cell, Vol. 102, Issue 6 https://doi.org/10.1042/BC20090165	journal	June 2010
Using small-angle neutron scattering to detect nanoscopic lipid domains Pan, Jianjun; Heberle, Frederick A.; Petruzielo, Robin S. Chemistry and Physics of Lipids, Vol. 170-171 https://doi.org/10.1016/j.chemphyslip.2013.02.012	journal	May 2013
Structure of Immune Stimulating Complex Matrices and Immune Stimulating Complexes in Suspension Determined by Small-Angle X-Ray Scattering Pedersen, Jan Skov; Oliveira, Cristiano L. P.; Hübschmann, Henriette Baun Biophysical Journal, Vol. 102, Issue 10 https://doi.org/10.1016/j.bpj.2012.03.071	journal	May 2012
Scattering from laterally heterogeneous vesicles. I. Model-independent analysis Pencer, Jeremy; Anghel, Vinicius N. P.; Kučerka, Norbert Journal of Applied Crystallography, Vol. 39, Issue 6 https://doi.org/10.1107/S0021889806035163	journal	November 2006
Small-angle neutron scattering from large unilamellar vesicles: An improved method for membrane thickness determination Pencer, J.; Hallett, F. Physical Review E, Vol. 61, Issue 3 https://doi.org/10.1103/PhysRevE.61.3003	journal	March 2000
Method of separated form factors for polydisperse vesicles Pencer, Jeremy; Krueger, Susan; Adams, Carl P. Journal of Applied Crystallography, Vol. 39, Issue 3 https://doi.org/10.1107/S0021889806005255	journal	May 2006
Detection of submicron-sized raft-like domains in membranes by small-angle neutron scattering Pencer, J.; Mills, T.; Anghel, V. The European Physical Journal E, Vol. 18, Issue 4 https://doi.org/10.1140/epje/e2005-00046-5	journal	November 2005
Phase behavior and domain size in sphingomyelin-containing lipid bilayers Petruzielo, Robin S.; Heberle, Frederick A.; Drazba, Paul Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1828, Issue 4 https://doi.org/10.1016/j.bbamem.2013.01.007	journal	April 2013
Thermal transitions of DMPG bilayers in aqueous solution: SAXS structural studies Riske, Karin A.; Amaral, Lia Q.; Lamy-Freund, M. Teresa Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1511, Issue 2 https://doi.org/10.1016/S0005-2736(01)00287-5	journal	April 2001
Determination of Structural Parameters and Hydration of Unilamellar POPC/C ₁₂ E ₄ Vesicles at High Water Excess from Neutron Scattering Curves Using a Novel Method of Evaluation Schmiedel, Herbert; Jörchel, Peter; Kiselev, Mikael The Journal of Physical Chemistry B, Vol. 105, Issue 1 https://doi.org/10.1021/jp001712e	journal	January 2001
Lipid rafts: now you see them, now you don't Shaw, Andrey S. Nature Immunology, Vol. 7, Issue 11 https://doi.org/10.1038/ni1405	journal	November 2006
Lipid sorting in epithelial cells Simons, Kai; Van Meer, Gerrit Biochemistry, Vol. 27, Issue 17 https://doi.org/10.1021/bi00417a001	journal	August 1988
Interpretation of small-angle scattering functions of dilute solutions and gases. A representation of the structures related to a one-particle scattering function Stuhrmann, H. B. Acta Crystallographica Section A, Vol. 26, Issue 3 https://doi.org/10.1107/S0567739470000748	journal	May 1970
CRYSOL – a Program to Evaluate X-ray Solution Scattering of Biological Macromolecules from Atomic Coordinates Svergun, D.; Barberato, C.; Koch, M. H. J. Journal of Applied Crystallography, Vol. 28, Issue 6 https://doi.org/10.1107/S0021889895007047	journal	December 1995
Small-angle scattering: direct structure analysis Svergun, D. I.; Feigin, L. A.; Schedrin, B. M. Acta Crystallographica Section A, Vol. 38, Issue 6 https://doi.org/10.1107/S0567739482001703	journal	November 1982
Seeing spots: Complex phase behavior in simple membranes Veatch, Sarah L.; Keller, Sarah L. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Vol. 1746, Issue 3 https://doi.org/10.1016/j.bbamcr.2005.06.010	journal	December 2005
Fluorescent Probes Alter Miscibility Phase Boundaries in Ternary Vesicles Veatch, Sarah L.; Leung, Sherry S. W.; Hancock, Robert E. W. The Journal of Physical Chemistry B, Vol. 111, Issue 3 https://doi.org/10.1021/jp067636i	journal	January 2007
Microdomains in Lipid Vesicles: Structure and Distribution Assessed by Small-Angle Neutron Scattering Vogtt, Karsten; Jeworrek, Christoph; Garamus, Vasil M. The Journal of Physical Chemistry B, Vol. 114, Issue 16 https://doi.org/10.1021/jp101167n	journal	April 2010
Small-angle scattering from spherical core–shell particles: an analytical scattering function for particles with Schulz–Flory size distribution Wagner, Joachim Journal of Applied Crystallography, Vol. 37, Issue 5 https://doi.org/10.1107/S002188980401581X	journal	September 2004
Gruppentheorie und ihre Anwendung auf die Quantenmechanik der Atomspektren Wigner, Eugen https://doi.org/10.1007/978-3-663-02555-9	book	January 1931
Phase studies of model biomembranes: Macroscopic coexistence of Lα+Lβ, with light-induced coexistence of Lα+Lo Phases Zhao, Jiang; Wu, Jing; Shao, Huilin Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1768, Issue 11 https://doi.org/10.1016/j.bbamem.2007.07.009	journal	November 2007

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Title: Scattering from phase-separated vesicles. I. An analytical form factor for multiple static domains

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