Surface sampling concentration and reaction probe with controller to adjust sampling position
Abstract
A method of analyzing a chemical composition of a specimen is described. The method can include providing a probe comprising an outer capillary tube and an inner capillary tube disposed co-axially within the outer capillary tube, where the inner and outer capillary tubes define a solvent capillary and a sampling capillary in fluid communication with one another at a distal end of the probe; contacting a target site on a surface of a specimen with a solvent in fluid communication with the probe; maintaining a plug volume proximate a solvent-specimen interface, wherein the plug volume is in fluid communication with the probe; draining plug sampling fluid from the plug volume through the sampling capillary; and analyzing a chemical composition of the plug sampling fluid with an analytical instrument. A system for performing the method is also described.
- Inventors:
- Publication Date:
- Research Org.:
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1264416
- Patent Number(s):
- 9,395,278
- Application Number:
- 13/936,715
- Assignee:
- UT-BATTELLE, LLC (Oak Ridge, TN)
- DOE Contract Number:
- AC05-00OR22725
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2013 Jul 08
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Citation Formats
Van Berkel, Gary J., and ElNaggar, Mariam S. Surface sampling concentration and reaction probe with controller to adjust sampling position. United States: N. p., 2016.
Web.
Van Berkel, Gary J., & ElNaggar, Mariam S. Surface sampling concentration and reaction probe with controller to adjust sampling position. United States.
Van Berkel, Gary J., and ElNaggar, Mariam S. 2016.
"Surface sampling concentration and reaction probe with controller to adjust sampling position". United States. https://www.osti.gov/servlets/purl/1264416.
@article{osti_1264416,
title = {Surface sampling concentration and reaction probe with controller to adjust sampling position},
author = {Van Berkel, Gary J. and ElNaggar, Mariam S.},
abstractNote = {A method of analyzing a chemical composition of a specimen is described. The method can include providing a probe comprising an outer capillary tube and an inner capillary tube disposed co-axially within the outer capillary tube, where the inner and outer capillary tubes define a solvent capillary and a sampling capillary in fluid communication with one another at a distal end of the probe; contacting a target site on a surface of a specimen with a solvent in fluid communication with the probe; maintaining a plug volume proximate a solvent-specimen interface, wherein the plug volume is in fluid communication with the probe; draining plug sampling fluid from the plug volume through the sampling capillary; and analyzing a chemical composition of the plug sampling fluid with an analytical instrument. A system for performing the method is also described.},
doi = {},
url = {https://www.osti.gov/biblio/1264416},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jul 19 00:00:00 EDT 2016},
month = {Tue Jul 19 00:00:00 EDT 2016}
}
Works referenced in this record:
Near-field laser ablation inductively coupled plasma mass spectrometry: a novel elemental analytical technique at the nanometer scale
journal, January 2009
- Zoriy, Myroslav V.; Becker, J. Sabine
- Rapid Communications in Mass Spectrometry, Vol. 23, Issue 1
Self-aspirating atmospheric pressure chemical ionization source for direct sampling of analytes on surfaces and in liquid solutions
journal, January 2005
- Asano, Keiji G.; Ford, Michael J.; Tomkins, Bruce A.
- Rapid Communications in Mass Spectrometry, Vol. 19, Issue 16
Field enhancement in apertureless near-field scanning optical microscopy
journal, January 2001
- Bohn, John L.; Nesbitt, D. J.; Gallagher, A.
- Journal of the Optical Society of America A, Vol. 18, Issue 12
The irradiation effect of a Nd–YAG pulsed laser on the CeO2 target in the liquid
journal, January 2004
- Chen, Jiwei; Dong, Qizhi; Yang, Jing
- Materials Letters, Vol. 58, Issue 3-4, p. 337-341
Looking at the nanoscale: scanning near-field optical microscopy
journal, February 2003
- De Serio, M.
- TrAC Trends in Analytical Chemistry, Vol. 22, Issue 2
Laser Ablation of a Sample In Liquid—LASIL
journal, January 2011
- Douglas, David N.; Crisp, Jenna L.; Reid, Helen J.
- Journal of Analytical Atomic Spectrometry, Vol. 26, Issue 6
Transmission studies of explosive vaporization of a transparent liquid film on an opaque solid surface induced by excimer‐laser‐pulsed irradiation
journal, September 1992
- Leung, P. T.; Do, Nhan; Klees, Leander
- Journal of Applied Physics, Vol. 72, Issue 6
Laser ablation in liquids as a new technique of sampling in elemental analysis of solid materials
journal, February 2009
- Muravitskaya, E. V.; Rosantsev, V. A.; Belkov, M. V.
- Spectrochimica Acta Part B: Atomic Spectroscopy, Vol. 64, Issue 2, p. 119-125
Near-Field Optical Microscopy and Spectroscopy with Pointed Probes
journal, May 2006
- Novotny, Lukas; Stranick, Stephan J.
- Annual Review of Physical Chemistry, Vol. 57, Issue 1
Towards Nanoscale Molecular Analysis at Atmospheric Pressure by a Near-Field Laser Ablation Ion Trap/Time-of-Flight Mass Spectrometer
journal, September 2008
- Schmitz, Thomas A.; Gamez, Gerardo; Setz, Patrick D.
- Analytical Chemistry, Vol. 80, Issue 17
Nanoscale Atmospheric Pressure Laser Ablation-Mass Spectrometry
journal, April 2001
- Stöckle, Raoul; Setz, Patrick; Deckert, Volker
- Analytical Chemistry, Vol. 73, Issue 7
Microsecond-resolved imaging of laser ablation at solid–liquid interface: investigation of formation process of nano-size metal colloids
journal, May 2004
- Tsuji, Takeshi; Tsuboi, Yasuyuki; Kitamura, Noboru
- Applied Surface Science, Vol. 229, Issue 1-4, p. 365-371
Established and emerging atmospheric pressure surface sampling/ionization techniques for mass spectrometry
journal, September 2008
- Van Berkel, Gary J.; Pasilis, Sofie P.; Ovchinnikova, Olga
- Journal of Mass Spectrometry, Vol. 43, Issue 9
Thin-Layer Chromatography and Electrospray Mass Spectrometry Coupled Using a Surface Sampling Probe
journal, November 2002
- Van Berkel, Gary J.; Sanchez, Amaury D.; Quirke, J. Martin E.
- Analytical Chemistry, Vol. 74, Issue 24
Hollow nanoparticle generation on laser-induced cavitation bubbles via bubble interface pinning
journal, September 2010
- Yan, Zijie; Bao, Ruqiang; Wright, Roger N.
- Applied Physics Letters, Vol. 97, Issue 12
Laser ablation in liquids: Applications in the synthesis of nanocrystals
journal, May 2007
- Yang, G.
- Progress in Materials Science, Vol. 52, Issue 4
Laser ablation in a liquid medium as a technique for solid sampling
journal, January 1991
- Iida, Yasuo; Tsuge, Akira; Uwamino, Yoshinori
- Journal of Analytical Atomic Spectrometry, Vol. 6, Issue 7
Bubble nucleation and pressure generation during laser cleaning of surfaces
journal, April 1997
- Yavas, O.; Schilling, A.; Bischof, J.
- Applied Physics A: Materials Science & Processing, Vol. 64, Issue 4
Pulsed laser‐induced desorption and optical imaging on a nanometer scale with scanning near‐field microscopy using chemically etched fiber tips
journal, April 1996
- Zeisel, Dieter; Nettesheim, Stefan; Dutoit, Bertrand
- Applied Physics Letters, Vol. 68, Issue 18
Apparatus for investigating fast chemical reactions by optical detection
patent, February 1978
- De Maeyer, Leo; Rabl, Carl-Roland; Jovin, Thomas M.
- US Patent Document 4,076,420
Composite analyzer tester
patent, May 1988
- Collins, Richard M.; Chance, Richard F.
- US Patent Document 4,745,809
Disposable combination cup and base
patent, September 1989
- Zimmer, John
- US Patent Document 4,865,199
Recyclable corrugated beverage container and holder
patent, April 1993
- Coffin, Sr., David W.
- US Patent Document 5,205,473
Method for selective removal of a material from a wafer's alignment marks
patent, December 1993
- Sandhu, Gurtej S.; Laulusa, Alan
- US Patent Document 5,271,798
Centrifugal method for concentrating macromolecules from a solution and device for carrying out said method
patent, July 1997
- Vassarotti, Vincenzo
- US Patent Document 5,647,990
Method and apparatus for the quantitative measurement of the corrosivity effect of residues present on the surface of electronic circuit assemblies
patent, July 1998
- Munson, Terry L.; Pauls, Douglas O.
- US Patent Document 5,783,938
System and method for on-line coupling of liquid capillary separations with matrix-assisted laser desorption/ionization mass spectrometry
patent, October 2000
- Gusev, Arkady I.; Hercules, David M.
- US Patent Document 6,140,639
Method and apparatus for etch of a specific subarea of a semiconductor work object
patent, September 2001
- Morgan, Paul A.; Torek, Kevin J.
- US Patent Document 6,290,863
Miniaturized fluid transfer device
patent, November 2002
- Wachs, Timothy; Henion, Jack
- US Patent Document 6,478,238
Methods and apparatus for the location and concentration of polar analytes using an alternating electric field
patent, March 2003
- Bryning, Zbigniew T.; Taylor, Theresa B.
- US Patent Document 6,537,433
Sampling probe for microarray read out using electrospray mass spectrometry
patent, October 2004
- Van Berkel, Gary J.
- US Patent Document 6,803,566
Detection of malaria parasites by mass spectrometry
patent, September 2007
- Demirev, Plamen A.; Feldman, Andrew B.; Kongkasuriyachai, Darin
- US Patent Document 7,270,948
Methods for mass spectrometry detection and quantification of specific target proteins in complex biological samples
patent, November 2008
- Everett, Nicholas P.; Petell, James K.; Young, Scott A.
- US Patent Document 7,445,907
Laser desorption—electrospray ion (ESI) source for mass spectrometers
patent, April 2009
- Kovtoun, Viatcheslav V.
- US Patent Document 7,525,105
Modular and reconfigurable multi-stage microreactor cartridge apparatus
patent, January 2010
- Matteo, Joseph C.
- US Patent Document 7,641,860
Mass spectroscopic reaction-monitoring method
patent, May 2010
- Shiea, Jentaie; Yuan, Cheng-Hui; Jheng, Jhih-Yuan
- US Patent Document 7,718,958
Methods and apparatus for ink delivery to nanolithographic probe systems
patent, July 2010
- Cruchon-Dupeyrat, Sylvain; Nelson, Michael; Elghanian, Robert
- US Patent Document 7,762,638
Direct flow injection analysis nebulization electrospray and APCI mass spectrometry
patent-application, November 2002
- Andrien, JR., Bruce A.; Banks, J. Fred; Boyle, James
- US Patent Application 10/150692; 20020168778
Sampling probe for microarray read out using electrospray mass spectrometry
patent-application, October 2003
- Van Berkel, Gary
- US Patent Application 10/123629; 20030193020
Method and apparatus for continuous sample deposition on sample support plates for liquid chromatography-matrix-assisted laser desorption/ionization mass spectrometry
patent-application, February 2004
- Stacey, Catherine
- US Patent Application 10/213144; 20040023410
Methods and devices for concentration and purification of analytes for chemical analysis including matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS)
patent-application, June 2005
- Hafeman, Dean; Dill, Kilian; Harkins, James B.
- US Patent Application 10/963336; 20050116161
Methods and compositions for assessing a sample by maldi mass spectrometry
patent-application, August 2005
- Lopes-Avila, Viorica; Hirschberg, David L.
- US Patent Application 11/001493; 20050178959
Container and method of making a container
patent-application, December 2005
- Kosth, Daniel A.
- US Patent Application 11/152481; 20050276937
Automated Analysis Of Complex Matrices Using Mass Spectrometer
patent-application, June 2007
- Keiser, Byron
- US Patent Application 11/567281; 20070138384
Means and method for analyzing samples by mass spectrometry
patent-application, September 2007
- Park, Melvin A.
- US Patent Application 11/388745; 20070224697
Quantitative Analysis of Surface-Derived Samples using Mass Spectrometry
patent-application, November 2007
- Cerda, Blas
- US Patent Application 11/744513; 20070259445
High power laser induced acoustic desorption probe
patent-application, December 2007
- Shea, Ryan C.; Kenttamaa, Hikka I.; Vaughn, Weldon E.
- US Patent Application 11/807400; 20070295902
Mass Spectrometry With Laser Ablation
patent-application, June 2008
- Nikolaev, Evgenij; Franzen, Jochen
- US Patent Application 11/943904; 20080128614
Apparatus and method for isolating a nucleic acid from a sample
patent-application, June 2008
- Bortolin, Laura T.; Parameswaran, Lalitha; Bobrow, JOhanna
- US Patent Application 11/804598; 20080131949
Electrospray-Assisted Laser-Induced Acoustic Desorption Ionization Mass Spectrometer and a Method for Mass Spectrometry
patent-application, December 2008
- Shiea, Jentaie
- US Patent Application 12/112532; 20080308722
Device for Processing a Biological And/or Chemical Sample and Method of Using the Same
patent-application, February 2009
- Oviso, Jr., Dominador Fortaleza; Ting, Dor Ngi; Ghadessy, Farid
- US Patent Application 11/996,237; 2009/0053689 Al
Increasing Ionization Efficiency in Mass Spectroscopy
patent-application, May 2009
- Schneider, Luke V.
- US Patent Application 12/167140; 20090121124
Differential Hemolysis of a Whole Blood Sample
patent-application, October 2009
- Kobold, Uwe; Duelffer, Thomas; Herrmann, Rupert
- US Patent Application 12/328890; 20090253210
Disposable Containers and Utensils for Sanitizing
patent-application, October 2009
- Kendall, Yvette Kathrynn
- US Patent Application 12/427129; 20090263440
Method of Preparing Sample for Matrix-Assisted Laser Desorption Ionization Mass Spectrometry and Matrix-Assisted Laser Desorption Ionization Mass Spectrometry
patent-application, February 2010
- Sato, Taka-aki; Aoki, Yutaka; Shimada, Takashi
- US Patent Application 12/443461; 20100038529
Method and system for formation and withdrawal of a sample from a surface to be analyzed
patent-application, September 2010
- Van Berkel, Gary J.; Kertesz, Vilmos
- US Patent Application 12/380980; 20100224013
Beverage Pod
patent-application, October 2011
- Delorme, Kevin S. J.
- US Patent Application 12/767478; 20110259205
Ion Generation Using Wetted Porous Material
patent-application, May 2012
- Ouyang, Zheng; Wang, He; Manicke, Nicholas E.
- US Patent Document 13/265110; 20120119079