Super-resolution microscopy reveals structural diversity in molecular exchange among peptide amphiphile nanofibres
Abstract
The dynamic behaviour of supramolecular systems is an important dimension of their potential functions. Here, we report on the use of stochastic optical reconstruction microscopy to study the molecular exchange of peptide amphiphile nanofibres, supramolecular systems known to have important biomedical functions. Solutions of nanofibres labelled with different dyes (Cy3 and Cy5) were mixed, and the distribution of dyes inserting into initially single-colour nanofibres was quantified using correlative image analysis. Our observations are consistent with an exchange mechanism involving monomers or small clusters of molecules inserting randomly into a fibre. Different exchange rates are observed within the same fibre, suggesting that local cohesive structures exist on the basis of beta-sheet discontinuous domains. The results reported here show that peptide amphiphile supramolecular systems can be dynamic and that their intermolecular interactions affect exchange patterns. Lastly, this information can be used to generate useful aggregate morphologies for improved biomedical function.
- Authors:
-
- Northwestern Univ., Evanston, IL (United States); Eindhoven Univ. of Technology, Eindhoven (The Netherlands); King's College London, London (United Kingdom)
- Eindhoven Univ. of Technology, Eindhoven (The Netherlands)
- Eindhoven Univ. of Technology, Eindhoven (The Netherlands); Institute for Bioengineering of Catalonia (IBEC), Barcelona (Spain)
- Northwestern Univ., Evanston, IL (United States)
- Publication Date:
- Research Org.:
- Northwestern Univ., Evanston, IL (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES); Dutch Ministry of Education, Culture and Science (Gravity program); European Research Council (ERC); Marie Curie FP7-PEOPLE-IOF program
- OSTI Identifier:
- 1261783
- Alternate Identifier(s):
- OSTI ID: 1820968
- Grant/Contract Number:
- FG02-00ER45810
- Resource Type:
- Journal Article: Accepted Manuscript
- Journal Name:
- Nature Communications
- Additional Journal Information:
- Journal Volume: 7; Journal Issue: 1; Journal ID: ISSN 2041-1723
- Publisher:
- Nature Publishing Group
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 36 MATERIALS SCIENCE; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 99 GENERAL AND MISCELLANEOUS; cells; multivalency; dynamics; medicine; vesicles; adhesion; systems; probes; biophysical chemistry; microscopy; structural biology; Biophysical chemistry Microscopy Structural biology
Citation Formats
da Silva, Ricardo M. P., van der Zwaag, Daan, Albertazzi, Lorenzo, Lee, Sungsoo S., Meijer, E. W., and Stupp, Samuel I. Super-resolution microscopy reveals structural diversity in molecular exchange among peptide amphiphile nanofibres. United States: N. p., 2016.
Web. doi:10.1038/ncomms11561.
da Silva, Ricardo M. P., van der Zwaag, Daan, Albertazzi, Lorenzo, Lee, Sungsoo S., Meijer, E. W., & Stupp, Samuel I. Super-resolution microscopy reveals structural diversity in molecular exchange among peptide amphiphile nanofibres. United States. https://doi.org/10.1038/ncomms11561
da Silva, Ricardo M. P., van der Zwaag, Daan, Albertazzi, Lorenzo, Lee, Sungsoo S., Meijer, E. W., and Stupp, Samuel I. 2016.
"Super-resolution microscopy reveals structural diversity in molecular exchange among peptide amphiphile nanofibres". United States. https://doi.org/10.1038/ncomms11561. https://www.osti.gov/servlets/purl/1261783.
@article{osti_1261783,
title = {Super-resolution microscopy reveals structural diversity in molecular exchange among peptide amphiphile nanofibres},
author = {da Silva, Ricardo M. P. and van der Zwaag, Daan and Albertazzi, Lorenzo and Lee, Sungsoo S. and Meijer, E. W. and Stupp, Samuel I.},
abstractNote = {The dynamic behaviour of supramolecular systems is an important dimension of their potential functions. Here, we report on the use of stochastic optical reconstruction microscopy to study the molecular exchange of peptide amphiphile nanofibres, supramolecular systems known to have important biomedical functions. Solutions of nanofibres labelled with different dyes (Cy3 and Cy5) were mixed, and the distribution of dyes inserting into initially single-colour nanofibres was quantified using correlative image analysis. Our observations are consistent with an exchange mechanism involving monomers or small clusters of molecules inserting randomly into a fibre. Different exchange rates are observed within the same fibre, suggesting that local cohesive structures exist on the basis of beta-sheet discontinuous domains. The results reported here show that peptide amphiphile supramolecular systems can be dynamic and that their intermolecular interactions affect exchange patterns. Lastly, this information can be used to generate useful aggregate morphologies for improved biomedical function.},
doi = {10.1038/ncomms11561},
url = {https://www.osti.gov/biblio/1261783},
journal = {Nature Communications},
issn = {2041-1723},
number = 1,
volume = 7,
place = {United States},
year = {Thu May 19 00:00:00 EDT 2016},
month = {Thu May 19 00:00:00 EDT 2016}
}
Web of Science
Works referenced in this record:
Supramolecular Chemistry and Self-Assembly in Organic Materials Design
journal, September 2013
- Stupp, Samuel I.; Palmer, Liam C.
- Chemistry of Materials, Vol. 26, Issue 1
Correlation Functions Quantify Super-Resolution Images and Estimate Apparent Clustering Due to Over-Counting
journal, February 2012
- Veatch, Sarah L.; Machta, Benjamin B.; Shelby, Sarah A.
- PLoS ONE, Vol. 7, Issue 2
The use of Nile Red to monitor the aggregation behavior in ternary surfactant-water-organic solvent systems
journal, January 2005
- Stuart, Marc C. A.; van de Pas, John C.; Engberts, Jan B. F. N.
- Journal of Physical Organic Chemistry, Vol. 18, Issue 9
Cellular Motility Driven by Assembly and Disassembly of Actin Filaments
journal, February 2003
- Pollard, Thomas D.; Borisy, Gary G.
- Cell, Vol. 112, Issue 4
Control of Vesicular Trafficking by Rho GTPases
journal, September 2003
- Symons, Marc; Rusk, Nicole
- Current Biology, Vol. 13, Issue 19
Cell death versus cell survival instructed by supramolecular cohesion of nanostructures
journal, February 2014
- Newcomb, Christina J.; Sur, Shantanu; Ortony, Julia H.
- Nature Communications, Vol. 5, Issue 1
Control of Vesicular Trafficking by Rho GTPases
journal, May 2003
- Symons, Marc; Rusk, Nicole
- Current Biology, Vol. 13, Issue 10
Consequences of chirality on the dynamics of a water-soluble supramolecular polymer
journal, February 2015
- Baker, Matthew B.; Albertazzi, Lorenzo; Voets, Ilja K.
- Nature Communications, Vol. 6, Issue 1
Atomistic Molecular Dynamics Simulations of Peptide Amphiphile Self-Assembly into Cylindrical Nanofibers
journal, March 2011
- Lee, One-Sun; Stupp, Samuel I.; Schatz, George C.
- Journal of the American Chemical Society, Vol. 133, Issue 10
Antitumor Activity of Peptide Amphiphile Nanofiber-Encapsulated Camptothecin
journal, October 2011
- Soukasene, Stephen; Toft, Daniel J.; Moyer, Tyson J.
- ACS Nano, Vol. 5, Issue 11
High-Affinity Peptide-Based Collagen Targeting Using Synthetic Phage Mimics: From Phage Display to Dendrimer Display
journal, August 2009
- Helms, Brett A.; Reulen, Sanne W. A.; Nijhuis, Sebastiaan
- Journal of the American Chemical Society, Vol. 131, Issue 33
Supramolecular Nanofibers of Peptide Amphiphiles for Medicine
journal, August 2013
- Webber, Matthew J.; Berns, Eric J.; Stupp, Samuel I.
- Israel Journal of Chemistry, Vol. 53, Issue 8
Energy landscapes and functions of supramolecular systems
journal, January 2016
- Tantakitti, Faifan; Boekhoven, Job; Wang, Xin
- Nature Materials, Vol. 15, Issue 4
Equilibrium Chain Exchange Kinetics of Diblock Copolymer Micelles: Tuning and Logarithmic Relaxation
journal, June 2006
- Lund, Reidar; Willner, Lutz; Richter, Dieter
- Macromolecules, Vol. 39, Issue 13
Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM)
journal, August 2006
- Rust, Michael J.; Bates, Mark; Zhuang, Xiaowei
- Nature Methods, Vol. 3, Issue 10
Tunable Mechanics of Peptide Nanofiber Gels
journal, March 2010
- Greenfield, Megan A.; Hoffman, Jessica R.; Olvera de la Cruz, Monica
- Langmuir, Vol. 26, Issue 5
Microspectroscopic imaging tracks the intracellular processing of a signal transduction protein: fluorescent-labeled protein kinase C beta I.
journal, August 1996
- Bastiaens, P. I.; Jovin, T. M.
- Proceedings of the National Academy of Sciences, Vol. 93, Issue 16
Molecular Mechanisms Controlling Actin Filament Dynamics in Nonmuscle Cells
journal, June 2000
- Pollard, Thomas D.; Blanchoin, Laurent; Mullins, R. Dyche
- Annual Review of Biophysics and Biomolecular Structure, Vol. 29, Issue 1
Multicolor Super-Resolution Imaging with Photo-Switchable Fluorescent Probes
journal, September 2007
- Bates, M.; Huang, B.; Dempsey, G. T.
- Science, Vol. 317, Issue 5845
Selective Adhesion, Lipid Exchange and Membrane-Fusion Processes between Vesicles of Various Sizes Bearing Complementary Molecular Recognition Groups
journal, June 2001
- Marchi-Artzner, Valérie; Gulik-Krzywicki, Thaddée; Guedeau-Boudeville, Marie-Alice
- ChemPhysChem, Vol. 2, Issue 6
Self-Assembly of Peptide−Amphiphile Nanofibers: The Roles of Hydrogen Bonding and Amphiphilic Packing
journal, June 2006
- Paramonov, Sergey E.; Jun, Ho-Wook; Hartgerink, Jeffrey D.
- Journal of the American Chemical Society, Vol. 128, Issue 22
Selective Adhesion, Lipid Exchange and Membrane-Fusion Processes between Vesicles of Various Sizes Bearing Complementary Molecular Recognition Groups
journal, June 2001
- Marchi-Artzner, Valérie; Gulik-Krzywicki, Thaddée; Guedeau-Boudeville, Marie-Alice
- ChemPhysChem, Vol. 2, Issue 6
The actin cytoskeleton in rapid steroid hormone actions: Actin Cytoskeleton and Steroid Hormones
journal, March 2014
- Stournaras, Christos; Gravanis, Achilles; Margioris, Andrew N.
- Cytoskeleton, Vol. 71, Issue 5
Cellular Motility Driven by Assembly and Disassembly of Actin Filaments
journal, May 2003
- Pollard, Thomas D.; Borisy, Gary G.
- Cell, Vol. 113, Issue 4
Super-resolution fluorescence imaging of organelles in live cells with photoswitchable membrane probes
journal, August 2012
- Shim, S. -H.; Xia, C.; Zhong, G.
- Proceedings of the National Academy of Sciences, Vol. 109, Issue 35
Probing Exchange Pathways in One-Dimensional Aggregates with Super-Resolution Microscopy
journal, May 2014
- Albertazzi, L.; van der Zwaag, D.; Leenders, C. M. A.
- Science, Vol. 344, Issue 6183
Tubulin post-translational modifications: encoding functions on the neuronal microtubule cytoskeleton
journal, August 2010
- Janke, Carsten; Kneussel, Matthias
- Trends in Neurosciences, Vol. 33, Issue 8
Shape-Dependent Targeting of Injured Blood Vessels by Peptide Amphiphile Supramolecular Nanostructures
journal, February 2015
- Moyer, Tyson J.; Kassam, Hussein A.; Bahnson, Edward S. M.
- Small, Vol. 11, Issue 23
Actin Structure and Function
journal, June 2011
- Dominguez, Roberto; Holmes, Kenneth C.
- Annual Review of Biophysics, Vol. 40, Issue 1
Super-Resolution Fluorescence Microscopy
book, March 2019
- Sanderson, Jeremy
- Understanding Light Microscopy
Super-Resolution Fluorescence Microscopy
journal, June 2009
- Huang, Bo; Bates, Mark; Zhuang, Xiaowei
- Annual Review of Biochemistry, Vol. 78, Issue 1
Spatiotemporal control and superselectivity in supramolecular polymers using multivalency
journal, July 2013
- Albertazzi, L.; Martinez-Veracoechea, F. J.; Leenders, C. M. A.
- Proceedings of the National Academy of Sciences, Vol. 110, Issue 30
25th Anniversary Article: Supramolecular Materials for Regenerative Medicine
journal, February 2014
- Boekhoven, Job; Stupp, Samuel I.
- Advanced Materials, Vol. 26, Issue 11
Multivalency as a Chemical Organization and Action Principle
journal, September 2012
- Fasting, Carlo; Schalley, Christoph A.; Weber, Marcus
- Angewandte Chemie International Edition, Vol. 51, Issue 42
Lipid transfer between phosphatidylcholine vesicles and human erythrocytes: exponential decrease in rate with increasing acyl chain length
journal, June 1985
- Ferrell, James E.; Lee, Kong Joo; Huestis, Wray H.
- Biochemistry, Vol. 24, Issue 12
Self-assembly for the synthesis of functional biomaterials
journal, February 2013
- Stephanopoulos, Nicholas; Ortony, Julia H.; Stupp, Samuel I.
- Acta Materialia, Vol. 61, Issue 3
Pathway Selection in Peptide Amphiphile Assembly
journal, June 2014
- Korevaar, Peter A.; Newcomb, Christina J.; Meijer, E. W.
- Journal of the American Chemical Society, Vol. 136, Issue 24
Tuning Supramolecular Rigidity of Peptide Fibers through Molecular Structure
journal, May 2010
- Pashuck, E. Thomas; Cui, Honggang; Stupp, Samuel I.
- Journal of the American Chemical Society, Vol. 132, Issue 17
Conformational preferences of amino acids in globular proteins
journal, October 1978
- Levitt, Michael
- Biochemistry, Vol. 17, Issue 20
Selective Differentiation of Neural Progenitor Cells by High-Epitope Density Nanofibers
journal, February 2004
- Silva, Gabriel A.; Czeisler, Catherine; Niece, Krista L.
- Science, Vol. 303, Issue 5662, p. 1352-1355
Supramolecular crafting of cell adhesion
journal, November 2007
- Storrie, Hannah; Guler, Mustafa O.; Abu-Amara, Suha N.
- Biomaterials, Vol. 28, Issue 31
Equilibrium exchange kinetics in n-alkyl–PEO polymeric micelles: single exponential relaxation and chain length dependence
journal, January 2012
- Zinn, Thomas; Willner, Lutz; Lund, Reidar
- Soft Matter, Vol. 8, Issue 3
25th Anniversary Article: Supramolecular Materials for Regenerative Medicine
journal, February 2014
- Boekhoven, Job; Stupp, Samuel I.
- Advanced Materials, Vol. 26, Issue 11
The use of Nile Red to monitor the aggregation behavior in ternary surfactant-water-organic solvent systems
journal, January 2005
- Stuart, Marc C. A.; van de Pas, John C.; Engberts, Jan B. F. N.
- Journal of Physical Organic Chemistry, Vol. 18, Issue 9
Shape-Dependent Targeting of Injured Blood Vessels by Peptide Amphiphile Supramolecular Nanostructures
journal, February 2015
- Moyer, Tyson J.; Kassam, Hussein A.; Bahnson, Edward S. M.
- Small, Vol. 11, Issue 23
Self-assembly for the synthesis of functional biomaterials
journal, February 2013
- Stephanopoulos, Nicholas; Ortony, Julia H.; Stupp, Samuel I.
- Acta Materialia, Vol. 61, Issue 3
Cellular Motility Driven by Assembly and Disassembly of Actin Filaments
journal, May 2003
- Pollard, Thomas D.; Borisy, Gary G.
- Cell, Vol. 113, Issue 4
Control of Vesicular Trafficking by Rho GTPases
journal, May 2003
- Symons, Marc; Rusk, Nicole
- Current Biology, Vol. 13, Issue 10
Conformational preferences of amino acids in globular proteins
journal, October 1978
- Levitt, Michael
- Biochemistry, Vol. 17, Issue 20
Self-Assembly of Peptide−Amphiphile Nanofibers: The Roles of Hydrogen Bonding and Amphiphilic Packing
journal, June 2006
- Paramonov, Sergey E.; Jun, Ho-Wook; Hartgerink, Jeffrey D.
- Journal of the American Chemical Society, Vol. 128, Issue 22
Atomistic Molecular Dynamics Simulations of Peptide Amphiphile Self-Assembly into Cylindrical Nanofibers
journal, March 2011
- Lee, One-Sun; Stupp, Samuel I.; Schatz, George C.
- Journal of the American Chemical Society, Vol. 133, Issue 10
Pathway Selection in Peptide Amphiphile Assembly
journal, June 2014
- Korevaar, Peter A.; Newcomb, Christina J.; Meijer, E. W.
- Journal of the American Chemical Society, Vol. 136, Issue 24
High-Affinity Peptide-Based Collagen Targeting Using Synthetic Phage Mimics: From Phage Display to Dendrimer Display
journal, August 2009
- Helms, Brett A.; Reulen, Sanne W. A.; Nijhuis, Sebastiaan
- Journal of the American Chemical Society, Vol. 131, Issue 33
Tuning Supramolecular Rigidity of Peptide Fibers through Molecular Structure
journal, May 2010
- Pashuck, E. Thomas; Cui, Honggang; Stupp, Samuel I.
- Journal of the American Chemical Society, Vol. 132, Issue 17
Tunable Mechanics of Peptide Nanofiber Gels
journal, March 2010
- Greenfield, Megan A.; Hoffman, Jessica R.; Olvera de la Cruz, Monica
- Langmuir, Vol. 26, Issue 5
Equilibrium Chain Exchange Kinetics of Diblock Copolymer Micelles: Tuning and Logarithmic Relaxation
journal, June 2006
- Lund, Reidar; Willner, Lutz; Richter, Dieter
- Macromolecules, Vol. 39, Issue 13
Antitumor Activity of Peptide Amphiphile Nanofiber-Encapsulated Camptothecin
journal, October 2011
- Soukasene, Stephen; Toft, Daniel J.; Moyer, Tyson J.
- ACS Nano, Vol. 5, Issue 11
Cell death versus cell survival instructed by supramolecular cohesion of nanostructures
journal, February 2014
- Newcomb, Christina J.; Sur, Shantanu; Ortony, Julia H.
- Nature Communications, Vol. 5, Issue 1
Consequences of chirality on the dynamics of a water-soluble supramolecular polymer
journal, February 2015
- Baker, Matthew B.; Albertazzi, Lorenzo; Voets, Ilja K.
- Nature Communications, Vol. 6, Issue 1
Energy landscapes and functions of supramolecular systems
journal, January 2016
- Tantakitti, Faifan; Boekhoven, Job; Wang, Xin
- Nature Materials, Vol. 15, Issue 4
More dyes enter the realm of nanoscopy
journal, September 2012
- Evanko, Daniel
- Nature Methods, Vol. 9, Issue 10
Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM)
journal, August 2006
- Rust, Michael J.; Bates, Mark; Zhuang, Xiaowei
- Nature Methods, Vol. 3, Issue 10
Spatiotemporal control and superselectivity in supramolecular polymers using multivalency
journal, July 2013
- Albertazzi, L.; Martinez-Veracoechea, F. J.; Leenders, C. M. A.
- Proceedings of the National Academy of Sciences, Vol. 110, Issue 30
Microspectroscopic imaging tracks the intracellular processing of a signal transduction protein: fluorescent-labeled protein kinase C beta I.
journal, August 1996
- Bastiaens, P. I.; Jovin, T. M.
- Proceedings of the National Academy of Sciences, Vol. 93, Issue 16
Multicolor Super-Resolution Imaging with Photo-Switchable Fluorescent Probes
journal, September 2007
- Bates, M.; Huang, B.; Dempsey, G. T.
- Science, Vol. 317, Issue 5845
Probing Exchange Pathways in One-Dimensional Aggregates with Super-Resolution Microscopy
journal, May 2014
- Albertazzi, L.; van der Zwaag, D.; Leenders, C. M. A.
- Science, Vol. 344, Issue 6183
Super-Resolution Fluorescence Microscopy
journal, June 2009
- Huang, Bo; Bates, Mark; Zhuang, Xiaowei
- Annual Review of Biochemistry, Vol. 78, Issue 1
Correlation Functions Quantify Super-Resolution Images and Estimate Apparent Clustering Due to Over-Counting
journal, February 2012
- Veatch, Sarah L.; Machta, Benjamin B.; Shelby, Sarah A.
- PLoS ONE, Vol. 7, Issue 2
Works referencing / citing this record:
Host Materials Transformable in Tumor Microenvironment for Homing Theranostics
journal, February 2017
- Yang, Pei-Pei; Luo, Qiang; Qi, Guo-Bin
- Advanced Materials, Vol. 29, Issue 15
Reversible self-assembly of superstructured networks
text, January 2018
- Z., Álvarez,; J. R., Wester,; C., Lynsky,
- American Association for the Advancement of Science
Into the Dynamics of a Supramolecular Polymer at Submolecular Resolution
journal, July 2017
- Bochicchio, Davide; Salvalaglio, Matteo; Pavan, Giovanni M.
- Nature Communications, Vol. 8, Issue 1
Reversible self-assembly of superstructured networks
journal, October 2018
- Freeman, Ronit; Han, Ming; Álvarez, Zaida
- Science, Vol. 362, Issue 6416
Quantification of functional crosslinker reaction kinetics via super-resolution microscopy of swollen microgels
journal, January 2019
- Karanastasis, Apostolos A.; Kenath, Gopal S.; Sundararaman, Ravishankar
- Soft Matter, Vol. 15, Issue 45
The Power of Confocal Laser Scanning Microscopy in Supramolecular Chemistry: In situ Real‐time Imaging of Stimuli‐Responsive Multicomponent Supramolecular Hydrogels
journal, January 2020
- Kubota, Ryou; Nakamura, Keisuke; Torigoe, Shogo
- ChemistryOpen, Vol. 9, Issue 1
A stochastic view on surface inhomogeneity of nanoparticles
journal, April 2019
- Post, R. A. J.; van der Zwaag, D.; Bet, G.
- Nature Communications, Vol. 10, Issue 1
Super-resolution Fluorescence Imaging for Materials Science
journal, August 2017
- Wöll, Dominik; Flors, Cristina
- Small Methods, Vol. 1, Issue 10
Quenched Stochastic Optical Reconstruction Microscopy (qSTORM) with Graphene Oxide
journal, November 2018
- Li, Ruiheng; Georgiades, Pantelis; Cox, Henry
- Scientific Reports, Vol. 8, Issue 1
Quantifying Guest-Host Dynamics in Supramolecular Assemblies to Analyze Their Robustness
journal, December 2018
- Bastings, Maartje M. C.; Hermans, Thomas M.; Spiering, A. J. H.
- Macromolecular Bioscience, Vol. 19, Issue 1
Polyprodrug Antimicrobials: Remarkable Membrane Damage and Concurrent Drug Release to Combat Antibiotic Resistance of Methicillin-Resistant Staphylococcus aureus
journal, August 2018
- Cao, Bing; Xiao, Fengfeng; Xing, Da
- Small, Vol. 14, Issue 41
Tuning the matrix metalloproteinase-1 degradability of peptide amphiphile nanofibers through supramolecular engineering
journal, January 2019
- Shi, Yejiao; Ferreira, Daniela S.; Banerjee, Jayati
- Biomaterials Science, Vol. 7, Issue 12
Designing stable, hierarchical peptide fibers from block co-polypeptide sequences
journal, January 2019
- van Rijt, Mark M. J.; Ciaffoni, Adriano; Ianiro, Alessandro
- Chemical Science, Vol. 10, Issue 39
Supramolecular materials based on AIE luminogens (AIEgens): construction and applications
journal, January 2020
- Li, Jie; Wang, Jianxing; Li, Haoxuan
- Chemical Society Reviews, Vol. 49, Issue 4
Molecular modelling of supramolecular polymers
journal, January 2018
- Bochicchio, Davide; Pavan, Giovanni M.
- Advances in Physics: X, Vol. 3, Issue 1
Functional Control of Peptide Amphiphile Assemblies via Modulation of Internal Cohesion and Surface Chemistry Switch
journal, August 2018
- Lu, Sheng; Cui, Weijia; Li, Jason
- Chemistry - A European Journal, Vol. 24, Issue 52
Supramolecular Copolymerization as a Strategy to Control the Stability of Self-Assembled Nanofibers
journal, May 2018
- Thota, Bala N. S.; Lou, Xianwen; Bochicchio, Davide
- Angewandte Chemie, Vol. 130, Issue 23
Supramolecular Copolymerization as a Strategy to Control the Stability of Self-Assembled Nanofibers
journal, May 2018
- Thota, Bala N. S.; Lou, Xianwen; Bochicchio, Davide
- Angewandte Chemie International Edition, Vol. 57, Issue 23
Controllable hierarchical self-assembly of porphyrin-derived supra-amphiphiles
journal, March 2019
- Wang, Shu-Ping; Lin, Wei; Wang, Xiaolin
- Nature Communications, Vol. 10, Issue 1
Polyprodrug Antimicrobials: Remarkable Membrane Damage and Concurrent Drug Release to Combat Antibiotic Resistance of Methicillin-Resistant Staphylococcus aureus
journal, August 2019
- Cao, Bing; Xiao, Fengfeng; Xing, Da
- Small, Vol. 15, Issue 33
Supramolecular Assembly of Peptide Amphiphiles
journal, September 2017
- Hendricks, Mark P.; Sato, Kohei; Palmer, Liam C.
- Accounts of Chemical Research, Vol. 50, Issue 10
Painting Supramolecular Polymers in Organic Solvents by Super-resolution Microscopy
journal, April 2018
- Adelizzi, Beatrice; Aloi, Antonio; Van Zee, Nathan J.
- ACS Nano, Vol. 12, Issue 5
Controlling protein activity by dynamic recruitment on a supramolecular polymer platform
journal, January 2018
- Wijnands, Sjors P. W.; Engelen, Wouter; Lafleur, René P. M.
- Nature Communications, Vol. 9, Issue 1
Controllable hierarchical self-assembly of porphyrin-derived supra-amphiphiles
journal, March 2019
- Wang, Shu-Ping; Lin, Wei; Wang, Xiaolin
- Nature Communications, Vol. 10, Issue 1
Amyloid-like staining property of RADA16-I nanofibers and its potential application in detecting and imaging the nanomaterial
journal, April 2018
- Chen, Yongzhu; Hua, Yusi; Zhang, Wensheng
- International Journal of Nanomedicine, Vol. Volume 13