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Title: Molecular Dissection of Induced Platinum Resistance through Functional and Gene Expression Analysis in a Cell Culture Model of Bladder Cancer

Journal Article · · PLoS ONE
 [1];  [1];  [1];  [2];  [3];  [1];  [1];  [1];  [4];  [3];  [3];  [3];  [3];  [5];  [5];  [1];  [6];  [2];  [7]
  1. Univ. of California, Davis, CA (United States)
  2. Univ. of California, Davis, CA (United States); Accelerated Medical Diagnostics Inc., Dublin, CA (United States)
  3. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
  4. Accelerated Medical Diagnostics Inc., Dublin, CA (United States)
  5. Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
  6. Univ. of California, Davis, CA (United States); VA Northern California Health Care System, Mather, CA (United States)
  7. Wayne State Univ., Detroit, MI (United States)

Research Organization:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
Sponsoring Organization:
USDOE
Grant/Contract Number:
AC52-07NA27344
OSTI ID:
1259484
Alternate ID(s):
OSTI ID: 1438769
Report Number(s):
LLNL-JRNL-737014
Journal Information:
PLoS ONE, Vol. 11, Issue 1; ISSN 1932-6203
Publisher:
Public Library of ScienceCopyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 12 works
Citation information provided by
Web of Science

References (61)

Phase II Trial of Weekly Paclitaxel in Patients With Previously Treated Advanced Urothelial Cancer journal February 2002
Oxaliplatin, tetraplatin, cisplatin, and carboplatin: Spectrum of activity in drug-resistant cell lines and in the cell lines of the national cancer institute's anticancer drug screen panel journal December 1996
Protein interactions with platinum–DNA adducts: from structure to function journal October 2004
HtrA1 Downregulation Induces Cisplatin Resistance in Lung Adenocarcinoma by Promoting Cancer Stem Cell-Like Properties: HtrA1 DOWNREGULATION INDUCES CISPLATIN RESISTANCE journal April 2014
Modulation of the Cellular Pharmacology of Cisplatin and Its Analogs by the Copper Exporters ATP7A and ATP7B journal June 2004
Enhanced DNA repair and resistance to cisplatin in human ovarian cancer journal December 1988
The platelet-sparing effect of paclitaxel is not related to changes in the pharmacokinetics of carboplatin journal November 2000
Long noncoding RNAs and the genetics of cancer journal May 2013
In vitro formation of DNA adducts by cisplatin, lobaplatin and oxaliplatin in calf thymus DNA in solution and in cultured human cells journal January 1996
The angiogenic factor CYR61 in breast cancer: molecular pathology and therapeutic perspectives. journal June 2003
Structure, Recognition, and Processing of Cisplatin−DNA Adducts journal September 1999
Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks journal March 2012
Enhanced repair of a cisplatin-damaged reporter chloramphenicol-O-acetyltransferase gene and altered activities of DNA polymerases α and β, and DNA ligase in cells of a human malignant glioma following in vivo cisplatin therapy journal January 1994
ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage journal May 2007
Differential analysis of gene regulation at transcript resolution with RNA-seq journal December 2012
Overexpression of dihydrodiol dehydrogenase is associated with cisplatin-based chemotherapy resistance in ovarian cancer patients journal April 2005
HtrA1, a potential predictor of response to cisplatin-based combination chemotherapy in gastric cancer: HtrA1 predicts chemoresistance in gastric cancer journal March 2011
Mechanism of cisplatin resistance in human urothelial carcinoma cells journal May 2012
Aquaporin 3 (AQP3) participates in the cytotoxic response to nucleoside-derived drugs journal September 2012
The Copper Transporter CTR1 Regulates Cisplatin Uptake in Saccharomyces cerevisiae journal November 2002
New platinum antitumor complexes journal December 1993
Calcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential journal October 2014
Nkx1-2 is a transcriptional repressor and is essential for the activation of Brachyury in P19 mouse embryonal carcinoma cell journal June 2012
The CpG Island Methylator Phenotype and Chromosomal Instability Are Inversely Correlated in Sporadic Colorectal Cancer journal January 2007
Cisplatin and Oxaliplatin, but Not Carboplatin and Nedaplatin, Are Substrates for Human Organic Cation Transporters (SLC22A1–3 and Multidrug and Toxin Extrusion Family) journal August 2006
Neoadjuvant Chemotherapy plus Cystectomy Compared with Cystectomy Alone for Locally Advanced Bladder Cancer journal August 2003
A microdosing approach for characterizing formation and repair of carboplatin-DNA monoadducts and chemoresistance journal March 2011
Phase II Trial of Weekly Paclitaxel in Patients With Previously Treated Advanced Urothelial Cancer journal February 2002
Cellular and molecular aspects of drugs of the future: oxaliplatin journal November 2002
Cellular processing of platinum anticancer drugs journal March 2005
Oxaliplatin-Induced Damage of Cellular DNA journal November 2000
Assessment of cytotoxicity, apoptosis and DNA damages in Colo320 colorectal cancer cells selected for oxaliplatin resistance: CYTOTOXICITY AND DNA DAMAGE IN COLO320 CELLS journal April 2011
Personalized medicine for targeted and platinum-based chemotherapy of lung and bladder cancer journal February 2013
Comparative analysis of the mutagenic activity of oxaliplatin and cisplatin in theHprt gene of CHO cells journal January 2005
Regulation of Androgen-Responsive Transcription by the Chromatin Remodeling Factor CHD8 journal June 2010
Pathophysiological roles of aldo–keto reductases (AKR1C1 and AKR1C3) in development of cisplatin resistance in human colon cancers journal February 2013
Enhanced dna repair and tolerance of DNA damage associated with resistance to cis-diammine-dichloroplatinum (II) after in vitro exposure of a human teratoma cell line to fractionated X-irradiation journal July 1990
Superior cytotoxicity and DNA cross-link induction by oxaliplatin versus cisplatin at lower cellular uptake in colorectal cancer cell lines journal January 2012
Blood clearance of radioactively labelled cis-diammine 1,1-cyclobutane dicarboxylate platinum(II) (CBDCA) in cancer patients journal August 1983
Induction of aldo-keto reductases (AKR1C1 and AKR1C3) abolishes the efficacy of daunorubicin chemotherapy for leukemic U937 cells journal January 2014
Benefit from upfront FOLFOXIRI and bevacizumab in BRAFV600E-mutated metastatic colorectal cancer patients: does primary tumour location matter? journal June 2022
Phase II Study of Pemetrexed for Second-Line Treatment of Transitional Cell Cancer of the Urothelium journal July 2006
Expression analysis of genes involved in oxaliplatin response and development of oxaliplatin-resistant HT29 colon cancer cells journal July 2006
Cisplatin resistance by induction of aldo-keto reductase family 1 member C2 in human bladder cancer cells journal December 2013
Chemoresistant Colorectal Cancer Cells, the Cancer Stem Cell Phenotype, and Increased Sensitivity to Insulin-like Growth Factor-I Receptor Inhibition journal February 2009
HtrA1 sensitizes ovarian cancer cells to cisplatin-induced cytotoxicity by targeting XIAP for degradation journal April 2011
Increased nucleotide excision repair in cisplatin-resistant ovarian cancer cells journal November 2000
Characterization of a clonal isolate of an oxaliplatin resistant ovarian carcinoma cell line A2780/C10 journal January 2007
ABCC5, ERCC2, XPA and XRCC1 transcript abundance levels correlate with cisplatin chemoresistance in non-small cell lung cancer cell lines journal January 2005
Reversal of inflammation-associated dihydrodiol dehydrogenases (AKR1C1 and AKR1C2) overexpression and drug resistance in nonsmall cell lung cancer cells by wogonin and chrysin journal January 2007
Gemcitabine and Cisplatin Versus Methotrexate, Vinblastine, Doxorubicin, and Cisplatin in Advanced or Metastatic Bladder Cancer: Results of a Large, Randomized, Multinational, Multicenter, Phase III Study journal September 2000
Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity journal July 2006
A High-Throughput Method for the Conversion of CO 2 Obtained from Biochemical Samples to Graphite in Septa-Sealed Vials for Quantification of 14 C via Accelerator Mass Spectrometry journal May 2003
CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer journal June 2006
High BAALC expression predicts chemoresistance in adult B-precursor acute lymphoblastic leukemia journal May 2010
Oxaliplatin induces different cellular and molecular chemoresistance patterns in colorectal cancer cell lines of identical origins journal January 2013
The CpG Island Methylator Phenotype and Chromosomal Instability Are Inversely Correlated in Sporadic Colorectal Cancer text January 2007
MutS Preferentially Recognizes Cisplatin- over Oxaliplatin-modified DNA journal November 2001
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays journal December 1983
Pharmacokinetics of Oxaliplatin in Humans journal January 2002
Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine). journal August 1979

Cited By (3)

Radiocarbon Tracers in Toxicology and Medicine: Recent Advances in Technology and Science journal May 2019
Tracking Tumor Colonization in Xenograft Mouse Models Using Accelerator Mass Spectrometry journal October 2018
DNA Adducts from Anticancer Drugs as Candidate Predictive Markers for Precision Medicine journal December 2016