Low excitatory innervation balances high intrinsic excitability of immature dentate neurons

Dieni, Cristina V.; Panichi, Roberto; Aimone, James B.; Kuo, Chay T.; Wadiche, Jacques I.; Overstreet-Wadiche, Linda

doi:10.1038/ncomms11313

Title: Low excitatory innervation balances high intrinsic excitability of immature dentate neurons

Journal Article · Wed Apr 20 00:00:00 EDT 2016 · Nature Communications

DOI:https://doi.org/10.1038/ncomms11313· OSTI ID:1249080

Dieni, Cristina V. ^[1]; Panichi, Roberto ^[2]; Aimone, James B. ^[3]; Kuo, Chay T. ^[4]; Wadiche, Jacques I. ^[5]; Overstreet-Wadiche, Linda ^[5]

Univ. of Alabama, Birmingham, AL (United States); Univ. of Perugia, Perugia (Italy)
Univ. of Perugia, Perugia (Italy)
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Duke Univ. School of Medicine, Durham, NC (United States)
Univ. of Alabama, Birmingham, AL (United States)

Persistent neurogenesis in the dentate gyrus produces immature neurons with high intrinsic excitability and low levels of inhibition that are predicted to be more broadly responsive to afferent activity than mature neurons. Mounting evidence suggests that these immature neurons are necessary for generating distinct neural representations of similar contexts, but it is unclear how broadly responsive neurons help distinguish between similar patterns of afferent activity. Here we show that stimulation of the entorhinal cortex in mouse brain slices paradoxically generates spiking of mature neurons in the absence of immature neuron spiking. Immature neurons with high intrinsic excitability fail to spike due to insufficient excitatory drive that results from low innervation rather than silent synapses or low release probability. Here, our results suggest that low synaptic connectivity prevents immature neurons from responding broadly to cortical activity, potentially enabling excitable immature neurons to contribute to sparse and orthogonal dentate representations.

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Research Organization:: Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

Sponsoring Organization:: USDOE National Nuclear Security Administration (NNSA)

Grant/Contract Number:: AC04-94AL85000

OSTI ID:: 1249080

Report Number(s):: SAND-2016-2583J; ncomms11313

Journal Information:: Nature Communications, Vol. 7; ISSN 2041-1723

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 55 works

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