Analysis of mutational signatures in exomes from B-cell lymphoma cell lines suggest APOBEC3 family members to be involved in the pathogenesis of primary effusion lymphoma
- Univ. Hospital Schleswig-Holstein, Christian-Albrechts-Univ., Kiel (Germany)
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Univ. Hospital of Cologne, Cologne (Germany)
- Deutsches Krebsforschungszentrum Heidelberg (DKFZ), Heidelberg (Germany)
- Leibniz-Institute DSMZ, Braunschweig (Germany)
- Wellcome Trust Cancer Sanger Institute, Hinxton (United Kingdom)
Here, primary effusion lymphoma (PEL) is a rare large B-cell neoplasm particularly affecting immunodeficient hosts with an increased incidence in young or middle-aged males infected with the HIV.1 The clinical outcome of patients with PEL is unfavorable with a median survival of <6 months.1 PEL has been closely associated with human herpes virus 8 (HHV8, previously called Kaposi sarcoma herpesvirus) infection.1 In some cases a coinfection of HHV8 with the Epstein–Barr Virus (EBV) has been described.1 HHV8 encodes various genes homologous to cellular genes that have proliferative and anti-apoptotic functions.2 Although HHV8 is supposed to be a major driver of PEL, it alone is not sufficient for a full-blown lymphomagenesis.2 PEL usually shows complex karyotypes with many chromosomal aberrations.3 This chromosomal complexity might be driven by the viral infection and lead to genetic alterations cooperating with HHV8 in PEL lymphomagenesis.4
- Research Organization:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- Sponsoring Organization:
- USDOE
- Grant/Contract Number:
- AC52-06NA25396
- OSTI ID:
- 1248630
- Report Number(s):
- LA-UR-15-20054; leu201522
- Journal Information:
- Leukemia, Vol. 29, Issue 7; ISSN 0887-6924
- Publisher:
- Nature Publishing Group (NPG)Copyright Statement
- Country of Publication:
- United States
- Language:
- English
Web of Science
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