Analysis of biosurfaces by neutron reflectometry: From simple to complex interfaces

Junghans, Ann; Watkins, Erik B.; Barker, Robert D.; Singh, Saurabh; Waltman, Mary Jo; Smith, Hillary L.; Pocivavsek, Luka; Majewski, Jaroslaw

doi:10.1116/1.4914948

Title: Analysis of biosurfaces by neutron reflectometry: From simple to complex interfaces

Journal Article · Mon Mar 16 00:00:00 EDT 2015 · Biointerphases

DOI:https://doi.org/10.1116/1.4914948· OSTI ID:1248580

Junghans, Ann ^[1]; Watkins, Erik B. ^[2]; Barker, Robert D. ^[3]; Singh, Saurabh ^[1]; Waltman, Mary Jo ^[4]; Smith, Hillary L. ^[5]; Pocivavsek, Luka ^[6]; Majewski, Jaroslaw ^[1]

Los Alamos National Lab. (LANL), Los Alamos, NM (United States) Center for Integrated Nanotechnologies (MPA-CINT), Lujan Neutron Scattering Center
Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Los Alamos Neutron Science Center (LANSCE), Lujan Neutron Scattering Center; Inst. Laue-Langevin (ILL), Grenoble (France)
Inst. Laue-Langevin (ILL), Grenoble (France)
Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Biosciences Division, Bioenergy and Biome Sciences
California Inst. of Technology (CalTech), Pasadena, CA (United States). Dept. of Applied Physics
Univ. of Pittsburgh, PA (United States). Department of Surgery

Because of its high sensitivity for light elements and the scattering contrast manipulation via isotopic substitutions, neutron reflectometry (NR) is an excellent tool for studying the structure of soft-condensed material. These materials include model biophysical systems as well as in situ living tissue at the solid–liquid interface. The penetrability of neutrons makes NR suitable for probing thin films with thicknesses of 5–5000 Å at various buried, for example, solid–liquid, interfaces [J. Daillant and A. Gibaud, Lect. Notes Phys. 770, 133 (2009); G. Fragneto-Cusani, J. Phys.: Condens. Matter 13, 4973 (2001); J. Penfold, Curr. Opin. Colloid Interface Sci. 7, 139 (2002)]. Over the past two decades, NR has evolved to become a key tool in the characterization of biological and biomimetic thin films. Highlighted In the current report are some of the authors' recent accomplishments in utilizing NR to study highly complex systems, including in-situ experiments. Such studies will result in a much better understanding of complex biological problems, have significant medical impact by suggesting innovative treatment, and advance the development of highly functionalized biomimetic materials.

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Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC52-06NA25396

OSTI ID:: 1248580

Report Number(s):: LA-UR-14-29503; BJIOBN

Journal Information:: Biointerphases, Vol. 10, Issue 1; ISSN 1934-8630

Country of Publication:: United States

Language:: English

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Cited by: 25 works

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Title: Analysis of biosurfaces by neutron reflectometry: From simple to complex interfaces

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