HIV Molecular Immunology 2015
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Theoretical Division
- Institucio Catalana de Recerca i Estudis Avancats (ICREA), Barcelona (Spain)
- Beth Israel Deaconess Medical Center, Boston, MA (United States). Division of Vaccine Research
- Utrecht University, Utrecht (Netherlands). Faculty of Biology
- Duke Univ., Durham, NC (United States). Duke Human Vaccine Institute and Departments of Medicine, Surgery and Immunology
- National Inst. of Health (NIH), Bethesda, MD (United States). Vaccine Research Center
- Cornell Univ., Ithaca, NY (United States). Weill Medical College
- Ragon Institute, Cambridge, MA (United States)
- Wisconsin Regional Primate Research Center, Madison, WI (United States)
The scope and purpose of the HIV molecular immunology database: HIV Molecular Immunology is a companion volume to HIV Sequence Compendium. This publication, the 2015 edition, is the PDF version of the web-based HIV Immunology Database (http://www.hiv.lanl.gov/ content/immunology/). The web interface for this relational database has many search options, as well as interactive tools to help immunologists design reagents and interpret their results. In the HIV Immunology Database, HIV-specific B-cell and T-cell responses are summarized and annotated. Immunological responses are divided into three parts, CTL, T helper, and antibody. Within these parts, defined epitopes are organized by protein and binding sites within each protein, moving from left to right through the coding regions spanning the HIV genome. We include human responses to natural HIV infections, as well as vaccine studies in a range of animal models and human trials. Responses that are not specifically defined, such as responses to whole proteins or monoclonal antibody responses to discontinuous epitopes, are summarized at the end of each protein section. Studies describing general HIV responses to the virus, but not to any specific protein, are included at the end of each part. The annotation includes information such as cross-reactivity, escape mutations, antibody sequence, TCR usage, functional domains that overlap with an epitope, immune response associations with rates of progression and therapy, and how specific epitopes were experimentally defined. Basic information such as HLA specificities for T-cell epitopes, isotypes of monoclonal antibodies, and epitope sequences are included whenever possible. All studies that we can find that incorporate the use of a specific monoclonal antibody are included in the entry for that antibody. A single T-cell epitope can have multiple entries, generally one entry per study. Finally, maps of all defined linear epitopes relative to the HXB2 reference proteins are provided. Alignments of CTL, helper T-cell, and antibody epitopes are available through the search interface on our web site at http:// www.hiv.lanl.gov/content/immunology.
- Research Organization:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- Sponsoring Organization:
- USDOE; National Institutes of Health (NIH)
- DOE Contract Number:
- AC52-06NA25396; AAI 12007-0000-01000
- OSTI ID:
- 1248095
- Report Number(s):
- LA-UR-16-22283
- Country of Publication:
- United States
- Language:
- English
Similar Records
Analyses of inter- and intra-patient variation in the V3 loop of the HIV-1 envelope protein
Analyses of inter- and intra-patient variation in the V3 loop of the HIV-1 envelope protein