Cytosolic delivery of materials with endosome-disrupting colloids

Helms, Brett A.; Bayles, Andrea R.

Title: Cytosolic delivery of materials with endosome-disrupting colloids

Patent · Tue Mar 15 00:00:00 EDT 2016

OSTI ID:1243071

Helms, Brett A.; Bayles, Andrea R.

A facile procedure to deliver nanocrystals to the cytosol of live cells that is both rapid and general. The technique employs a unique cationic core-shell polymer colloid that directs nanocrystals to the cytosol of living cells within a few hours of incubation. The present methods and compositions enable a host of advanced applications arising from efficient cytosolic delivery of nanocrystal imaging probes: from single particle tracking experiments to monitoring protein-protein interactions in live cells for extended periods.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC02-05CH11231

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Number(s):: 9,284,188

Application Number:: 13/225,199

OSTI ID:: 1243071

Resource Relation:: Patent File Date: 2011 Sep 02

Country of Publication:: United States

Language:: English

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2'-Fluoronucleosides Schinazi, Raymond; Liotta, Dennis; Chu, Chung https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20040254141 US Patent Application 10/796529; 20040254141	patent-application	December 2004
Method for producing temporarily cross-linked cellulose ethers Perplies, Eberhard; Erdler, Manfred https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20050261490 US Patent Application 10/524455; 20050261490	patent-application	November 2005

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