Dried plum diet protects from bone loss caused by ionizing radiation

Schreurs, A. -S.; Shirazi-Fard, Y.; Shahnazari, M.; Alwood, J. S.; Truong, T. A.; Tahimic, C. G. T.; Limoli, C. L.; Turner, N. D.; Halloran, B.; Globus, R. K.

doi:10.1038/srep21343

Title: Dried plum diet protects from bone loss caused by ionizing radiation

Journal Article · Thu Feb 11 00:00:00 EST 2016 · Scientific Reports

DOI:https://doi.org/10.1038/srep21343· OSTI ID:1242248

Schreurs, A. -S. ^[1]; Shirazi-Fard, Y. ^[1]; Shahnazari, M. ^[1]; Alwood, J. S. ^[1]; Truong, T. A. ^[1]; Tahimic, C. G. T. ^[1]; Limoli, C. L. ^[2]; Turner, N. D. ^[3]; Halloran, B. ^[4]; Globus, R. K. ^[1]

NASA Ames Research Center, Moffett Field, CA (United States)
Univ. of California, Irvine, CA (United States)
Texas A & M Univ., College Station, TX (United States)
Univ. of California, San Francisco, CA (United States)

Bone loss caused by ionizing radiation is a potential health concern for radiotherapy patients, radiation workers and astronauts. In animal studies, exposure to ionizing radiation increases oxidative damage in skeletal tissues, and results in an imbalance in bone remodeling initiated by increased bone-resorbing osteoclasts. Therefore, we evaluated various candidate interventions with antioxidant or antiinflammatory activities (antioxidant cocktail, dihydrolipoic acid, ibuprofen, dried plum) both for their ability to blunt the expression of resorption-related genes in marrow cells after irradiation with either gamma rays (photons, 2 Gy) or simulated space radiation (protons and heavy ions, 1 Gy) and to prevent bone loss. Dried plum was most effective in reducing the expression of genes related to bone resorption (Nfe2l2, Rankl, Mcp1, Opg, TNF-α) and also preventing later cancellous bone decrements caused by irradiation with either photons or heavy ions. Furthermore, dietary supplementation with DP may prevent the skeletal effects of radiation exposures either in space or on Earth.

View Accepted Manuscript (DOE)

Cite

Export

Save

Research Organization:: NASA Ames Research Center (ARC), Moffett Field, Mountain View, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: SC0001507

OSTI ID:: 1242248

Journal Information:: Scientific Reports, Vol. 6; ISSN 2045-2322

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

Citation Metrics:

Cited by: 40 works

Citation information provided by
Web of Science

References (64)

Postoperative radiation therapy after hip replacement in high-risk patients for development of heterotopic bone formation Hashem, R.; Tanzer, M.; Rene, N. Cancer/Radiothérapie, Vol. 15, Issue 4 https://doi.org/10.1016/j.canrad.2010.10.003	journal	July 2011
Dried plum polyphenols attenuate the detrimental effects of TNF-α on osteoblast function coincident with up-regulation of Runx2, Osterix and IGF-I Bu, So Young; Hunt, Tamara S.; Smith, Brenda J. The Journal of Nutritional Biochemistry, Vol. 20, Issue 1 https://doi.org/10.1016/j.jnutbio.2007.11.012	journal	January 2009
The Influence of Therapeutic Radiation on the Patterns of Bone Marrow in Ovary-Intact and Ovariectomized Mice Hui, Susanta K.; Sharkey, Leslie; Kidder, Louis S. PLoS ONE, Vol. 7, Issue 8 https://doi.org/10.1371/journal.pone.0042668	journal	August 2012
Spaceflight-induced Bone Loss: Is there an Osteoporosis Risk? Sibonga, Jean D. Current Osteoporosis Reports, Vol. 11, Issue 2 https://doi.org/10.1007/s11914-013-0136-5	journal	April 2013
Microgravity Induces Pelvic Bone Loss through Osteoclastic Activity, Osteocytic Osteolysis, and Osteoblastic Cell Cycle Inhibition by CDKN1a/p21 Blaber, Elizabeth A.; Dvorochkin, Natalya; Lee, Chialing PLoS ONE, Vol. 8, Issue 4 https://doi.org/10.1371/journal.pone.0061372	journal	April 2013
Fruits and dietary phytochemicals in bone protection Shen, Chwan-Li; von Bergen, Vera; Chyu, Ming-Chien Nutrition Research, Vol. 32, Issue 12 https://doi.org/10.1016/j.nutres.2012.09.018	journal	December 2012
Antioxidant Diet Supplementation Starting 24 Hours after Exposure Reduces Radiation Lethality Brown, Stephen L.; Kolozsvary, Andrew; Liu, Jianguo Radiation Research, Vol. 173, Issue 4 https://doi.org/10.1667/rr1716.1	journal	April 2010
Mechanical loading causes site-specific anabolic effects on bone following exposure to ionizing radiation Shirazi-Fard, Yasaman; Alwood, Joshua S.; Schreurs, Ann-Sofie Bone, Vol. 81 https://doi.org/10.1016/j.bone.2015.07.019	journal	December 2015
Heavy ion irradiation and unloading effects on mouse lumbar vertebral microarchitecture, mechanical properties and tissue stresses Alwood, J. S.; Yumoto, K.; Mojarrab, R. Bone, Vol. 47, Issue 2 https://doi.org/10.1016/j.bone.2010.05.004	journal	August 2010
The combined effects of reduced weightbearing and ionizing radiation on splenic lymphocyte population and function Sanzari, Jenine K.; Wilson, Jolaine M.; Wagner, Erika B. International Journal of Radiation Biology, Vol. 87, Issue 10 https://doi.org/10.3109/09553002.2011.595875	journal	July 2011
Effects of Dried Plum Supplementation on Bone Metabolism in Adult C57BL/6 Male Mice Smith, B. J.; Graef, J. L.; Wronski, T. J. Calcified Tissue International, Vol. 94, Issue 4 https://doi.org/10.1007/s00223-013-9819-2	journal	December 2013
Bisphosphonates in the treatment of patients with lung cancer and metastatic bone disease: a systematic review and meta-analysis Lopez-Olivo, Maria A.; Shah, Nimit A.; Pratt, Greg Supportive Care in Cancer, Vol. 20, Issue 11 https://doi.org/10.1007/s00520-012-1563-z	journal	September 2012
Space Radiation Risks for Astronauts on Multiple International Space Station Missions Cucinotta, Francis A. PLoS ONE, Vol. 9, Issue 4 https://doi.org/10.1371/journal.pone.0096099	journal	April 2014
Dried Plum’s Unique Capacity to Reverse Bone Loss and Alter Bone Metabolism in Postmenopausal Osteoporosis Model Rendina, Elizabeth; Hembree, Kelsey D.; Davis, McKale R. PLoS ONE, Vol. 8, Issue 3 https://doi.org/10.1371/journal.pone.0060569	journal	March 2013
Dried Fruits: Excellent in Vitro and in Vivo Antioxidants Vinson, Joe A.; Zubik, Ligia; Bose, Pratima Journal of the American College of Nutrition, Vol. 24, Issue 1 https://doi.org/10.1080/07315724.2005.10719442	journal	February 2005
PTH1–34 alleviates radiotherapy-induced local bone loss by improving osteoblast and osteocyte survival Chandra, Abhishek; Lin, Tiao; Tribble, Mary Beth Bone, Vol. 67 https://doi.org/10.1016/j.bone.2014.06.030	journal	October 2014
Trabecular bone architecture in the pathogenesis and prevention of fracture Parfitt, A. Michael The American Journal of Medicine, Vol. 82, Issue 1 https://doi.org/10.1016/0002-9343(87)90274-9	journal	January 1987
Rabbiteye blueberry prevents osteoporosis in ovariectomized rats Li, Tao; Wu, Shou-Mian; Xu, Zhi-Yuan Journal of Orthopaedic Surgery and Research, Vol. 9, Issue 1 https://doi.org/10.1186/s13018-014-0056-9	journal	August 2014
Vascular expression of the chemokine CX3CL1 promotes osteoclast recruitment and exacerbates bone resorption in an irradiated murine model Han, Ki Hoon; Ryu, Jae Won; Lim, Kyung-Eun Bone, Vol. 61 https://doi.org/10.1016/j.bone.2013.12.032	journal	April 2014
Antioxidant-Chemoprevention Diet Ameliorates Late Effects of Total-Body Irradiation and Supplements Radioprotection by MnSOD-Plasmid Liposome Administration Epperly, Michael W.; Wang, Hong; Jones, Jeffrey A. Radiation Research, Vol. 175, Issue 6 https://doi.org/10.1667/rr2398.1	journal	June 2011
Combining Fructooligosaccharide and Dried Plum Has the Greatest Effect on Restoring Bone Mineral Density Among Select Functional Foods and Bioactive Compounds Arjmandi, Bahram H.; Johnson, Catherine D.; Campbell, Sara C. Journal of Medicinal Food, Vol. 13, Issue 2 https://doi.org/10.1089/jmf.2009.0068	journal	April 2010
Chemotherapy- and Irradiation-Induced Bone Loss in Adults with Solid Tumors Wissing, Michel D. Current Osteoporosis Reports, Vol. 13, Issue 3 https://doi.org/10.1007/s11914-015-0266-z	journal	February 2015
Ionizing Radiation Stimulates Expression of Pro-Osteoclastogenic Genes in Marrow and Skeletal Tissue Alwood, Joshua S.; Shahnazari, Mohammad; Chicana, Betsabel Journal of Interferon & Cytokine Research, Vol. 35, Issue 6 https://doi.org/10.1089/jir.2014.0152	journal	June 2015
Dietary supplementation with dried plum prevents ovariectomy-induced bone loss while modulating the immune response in C57BL/6J mice Rendina, Elizabeth; Lim, Yin F.; Marlow, Denver The Journal of Nutritional Biochemistry, Vol. 23, Issue 1 https://doi.org/10.1016/j.jnutbio.2010.10.010	journal	January 2012
Dried plum prevents bone loss in a male osteoporosis model via IGF-I and the RANK pathway Franklin, M.; Bu, S. Y.; Lerner, M. R. Bone, Vol. 39, Issue 6 https://doi.org/10.1016/j.bone.2006.05.024	journal	December 2006
Effects of Dietary Supplements on the Space Radiation-Induced Reduction in Total Antioxidant Status in CBA Mice Guan, Jun; Stewart, Jelena; Ware, Jeffrey H. Radiation Research, Vol. 165, Issue 4 https://doi.org/10.1667/rr3523.1	journal	April 2006
Low-Dose, Ionizing Radiation and Age-Related Changes in Skeletal Microarchitecture Alwood, Joshua S.; Kumar, Akhilesh; Tran, Luan H. Journal of Aging Research, Vol. 2012 https://doi.org/10.1155/2012/481983	journal	January 2012
Bone mineral loss induced by anticancer treatment for gynecological malignancies in premenopausal women Nishio, Keina; Tanabe, Akiko; Maruoka, Risa Endocrine Connections, Vol. 2, Issue 1 https://doi.org/10.1530/ec-12-0043	journal	March 2013
Increased dietary iron and radiation in rats promote oxidative stress, induce localized and systemic immune system responses, and alter colon mucosal environment Morgan, Jennifer L. L.; Ritchie, Lauren E.; Crucian, Brian E. The FASEB Journal, Vol. 28, Issue 3 https://doi.org/10.1096/fj.13-239418	journal	March 2014
The 21st-Century Landscape of Adult Fractures: Cohort Study of a Complete Adult Regional Population: ADULT FRACTURE EPIDEMIOLOGY WITH RECENT TIME TRENDS Rosengren, Björn E.; Karlsson, Magnus; Petersson, Ingemar Journal of Bone and Mineral Research, Vol. 30, Issue 3 https://doi.org/10.1002/jbmr.2370	journal	February 2015
Selective inhibition of TNFR1 reduces osteoclast numbers and is differentiated from anti-TNF in a LPS-driven model of inflammatory bone loss Espirito Santo, A. I.; Ersek, A.; Freidin, A. Biochemical and Biophysical Research Communications, Vol. 464, Issue 4 https://doi.org/10.1016/j.bbrc.2015.07.094	journal	September 2015
A report from Fukushima: an assessment of bone health in an area affected by the Fukushima nuclear plant incident Ishii, Takeaki; Ito, Kazuo; Kato, Shigeaki Journal of Bone and Mineral Metabolism, Vol. 31, Issue 6 https://doi.org/10.1007/s00774-013-0482-5	journal	August 2013
Volumetric quantitative computed tomography of the proximal femur: Precision and relation to bone strength Lang, T. F.; Keyak, J. H.; Heitz, M. W. Bone, Vol. 21, Issue 1 https://doi.org/10.1016/s8756-3282(97)00072-0	journal	July 1997
Skeletal health in long-duration astronauts: Nature, assessment, and management recommendations from the NASA bone summit: SKELETAL HEALTH IN LONG-DURATION ASTRONAUTS Orwoll, Eric S.; Adler, Robert A.; Amin, Shreyasee Journal of Bone and Mineral Research, Vol. 28, Issue 6 https://doi.org/10.1002/jbmr.1948	journal	May 2013
Exposure to Ionizing Radiation and Development of Bone Sarcoma: New Insights Based on Atomic-Bomb Survivors of Hiroshima and Nagasaki Samartzis, Dino; Nishi, Nobuo; Hayashi, Mikiko The Journal of Bone and Joint Surgery-American Volume, Vol. 93, Issue 11 https://doi.org/10.2106/jbjs.j.00256	journal	January 2011
Risedronate prevents early radiation-induced osteoporosis in mice at multiple skeletal locations Willey, Jeffrey S.; Livingston, Eric W.; Robbins, Michael E. Bone, Vol. 46, Issue 1 https://doi.org/10.1016/j.bone.2009.09.002	journal	January 2010
Evidence for anti-inflammatory and antioxidative properties of dried plum polyphenols in macrophage RAW 264.7 cells Hooshmand, Shirin; Kumar, Ajay; Zhang, Ji Yao Food & Function, Vol. 6, Issue 5 https://doi.org/10.1039/c5fo00173k	journal	January 2015
Anti-hyperglycemic effects of plum in a rat model of obesity and type 2 diabetes, Wistar fatty rat Utsunomiya, Hirotoshi; Yamakawa, Tadashi; Kamei, Junzo Biomedical Research, Vol. 26, Issue 5 https://doi.org/10.2220/biomedres.26.193	journal	January 2005
Space Radiation: The Number One Risk to Astronaut Health beyond Low Earth Orbit Chancellor, Jeffery; Scott, Graham; Sutton, Jeffrey Life, Vol. 4, Issue 3 https://doi.org/10.3390/life4030491	journal	September 2014
Dietary Dried Plum Increases Bone Mass in Adult and Aged Male Mice Halloran, Bernard P.; Wronski, Thomas J.; VonHerzen, Douglas C. The Journal of Nutrition, Vol. 140, Issue 10 https://doi.org/10.3945/jn.110.124198	journal	August 2010
Dried Plum Polyphenols Inhibit Osteoclastogenesis by Downregulating NFATc1 and Inflammatory Mediators Bu, So Young; Lerner, Megan; Stoecker, Barbara J. Calcified Tissue International, Vol. 82, Issue 6 https://doi.org/10.1007/s00223-008-9139-0	journal	May 2008
Predominant contribution of the dose received from constituent heavy-ions in the induction of gastrointestinal tumorigenesis after simulated space radiation exposure Suman, Shubhankar; Kumar, Santosh; Kallakury, Bhaskar V. S. Radiation and Environmental Biophysics, Vol. 61, Issue 4 https://doi.org/10.1007/s00411-022-00997-z	journal	September 2022
Short-Term Effects of Whole-Body Exposure to ⁵⁶ Fe Ions in Combination with Musculoskeletal Disuse on Bone Cells Yumoto, Kenji; Globus, Ruth K.; Mojarrab, Rose Radiation Research, Vol. 173, Issue 4 https://doi.org/10.1667/RR1754.1	journal	April 2010
Early Increase in Osteoclast Number in Mice after Whole-Body Irradiation with 2 Gy X Rays Willey, Jeffrey S.; Lloyd, Shane A. J.; Robbins, Michael E. Radiation Research, Vol. 170, Issue 3 https://doi.org/10.1667/rr1388.1	journal	September 2008
Men and Women in Space: Bone Loss and Kidney Stone Risk After Long-Duration Spaceflight: BONE LOSS AND KIDNEY STONE RISK IN SPACEFLIGHT Smith, Scott M.; Zwart, Sara R.; Heer, Martina Journal of Bone and Mineral Research, Vol. 29, Issue 7 https://doi.org/10.1002/jbmr.2185	journal	June 2014
Phytonutrients for bone health during ageing: Phytonutrients for bone health Sacco, Sandra Maria; Horcajada, Marie-Noëlle; Offord, Elizabeth British Journal of Clinical Pharmacology, Vol. 75, Issue 3 https://doi.org/10.1111/bcp.12033	journal	February 2013
Effect of proton irradiation followed by hindlimb unloading on bone in mature mice: A model of long-duration spaceflight A., Bateman, Ted; Leidamarie, Tirado-Lee,; J., Pecaut, Michael The University of North Carolina at Chapel Hill University Libraries https://doi.org/10.17615/a8k3-g861	text	January 2012
Bone remodelling in inflammatory arthritis Goldring, Steven R.; Purdue, P. Edward; Crotti, Tania N. Annals of the Rheumatic Diseases, Vol. 72, Issue suppl 2 https://doi.org/10.1136/annrheumdis-2012-202199	journal	December 2012
Spaceflight-relevant types of ionizing radiation and cortical bone: Potential LET effect? Lloyd, Shane A. J.; Bandstra, Eric R.; Travis, Neil D. Advances in Space Research, Vol. 42, Issue 12 https://doi.org/10.1016/j.asr.2008.08.006	journal	December 2008
Dried Plums and Their Products: Composition and Health Effects–An Updated Review Stacewicz-Sapuntzakis, M. Critical Reviews in Food Science and Nutrition, Vol. 53, Issue 12 https://doi.org/10.1080/10408398.2011.563880	journal	January 2013
Incidence and Predictors of Multiple Fractures Despite High Adherence to Oral Bisphosphonates: A Binational Population-Based Cohort Study: INCIDENCE/PREDICTORS OF FRACTURES DESPITE HIGH ADHERENCE TO ORAL BPS Hawley, Samuel; Javaid, M. Kassim; Rubin, Katrine H. Journal of Bone and Mineral Research, Vol. 31, Issue 1 https://doi.org/10.1002/jbmr.2595	journal	January 2016
Sclerostin inhibition: a novel therapeutic approach in the treatment of osteoporosis Lewiecki, E. Michael; Shah, Arti; Shoback, Dolores International Journal of Women's Health https://doi.org/10.2147/ijwh.s73244	journal	June 2015
Addition of Fructooligosaccharides and Dried Plum to Soy-Based Diets Reverses Bone Loss in the Ovariectomized Rat Johnson, Catherine D.; Lucas, Edralin A.; Hooshmand, Shirin Evidence-Based Complementary and Alternative Medicine, Vol. 2011 https://doi.org/10.1093/ecam/nen050	journal	January 2011
Feeding Blueberry Diets to Young Rats Dose-Dependently Inhibits Bone Resorption through Suppression of RANKL in Stromal Cells Zhang, Jian; Lazarenko, Oxana P.; Kang, Jie PLoS ONE, Vol. 8, Issue 8 https://doi.org/10.1371/journal.pone.0070438	journal	August 2013
Effect of proton irradiation followed by hindlimb unloading on bone in mature mice: A model of long-duration spaceflight Lloyd, Shane A.; Bandstra, Eric R.; Willey, Jeffrey S. Bone, Vol. 51, Issue 4 https://doi.org/10.1016/j.bone.2012.07.001	journal	October 2012
Historical height loss, vertebral deformity, and health-related quality of life in Hiroshima cohort study Masunari, N.; Fujiwara, S.; Nakata, Y. Osteoporosis International, Vol. 18, Issue 11 https://doi.org/10.1007/s00198-007-0392-2	journal	June 2007
Measurements of Energetic Particle Radiation in Transit to Mars on the Mars Science Laboratory Zeitlin, C.; Hassler, D. M.; Cucinotta, F. A. Science, Vol. 340, Issue 6136 https://doi.org/10.1126/science.1235989	journal	May 2013
Oxidative stress and gamma radiation-induced cancellous bone loss with musculoskeletal disuse Kondo, Hisataka; Yumoto, Kenji; Alwood, Joshua S. Journal of Applied Physiology, Vol. 108, Issue 1 https://doi.org/10.1152/japplphysiol.00294.2009	journal	January 2010
Effects of Dietary Antioxidant Supplementation on the Development of Malignant Lymphoma and Other Neoplastic Lesions in Mice Exposed to Proton or Iron-Ion Radiation Kennedy, Ann R.; Davis, James G.; Carlton, William Radiation Research, Vol. 169, Issue 6 https://doi.org/10.1667/rr1296.1	journal	June 2008
Characterization of the Radiation-Damaged Precursor Cells in bone Marrow Based on Modeling of the Peripheral Blood Granulocytes Response Hu, Shaowen; Cucinotta, Francis A. Health Physics, Vol. 101, Issue 1 https://doi.org/10.1097/hp.0b013e31820dba65	journal	January 2011
Total-Body Irradiation of Postpubertal Mice with ¹³⁷ Cs Acutely Compromises the Microarchitecture of Cancellous Bone and Increases Osteoclasts Kondo, Hisataka; Searby, Nancy D.; Mojarrab, Rose Radiation Research, Vol. 171, Issue 3 https://doi.org/10.1667/RR1463.1	journal	March 2009
Dietary Antioxidants Protect Hematopoietic Cells and Improve Animal Survival after Total-Body Irradiation Wambi, Chris; Sanzari, Jenine; Wan, X. Steven Radiation Research, Vol. 169, Issue 4 https://doi.org/10.1667/rr1204.1	journal	April 2008
Oxidative stress response and Nrf2 signaling in aging Zhang, Hongqiao; Davies, Kelvin J. A.; Forman, Henry Jay Free Radical Biology and Medicine, Vol. 88 https://doi.org/10.1016/j.freeradbiomed.2015.05.036	journal	November 2015
Dried Plums Modify Colon Microbiota Composition And Spatial Distribution, And Protect Against Chemically‐Induced Carcinogenesis Seidel, D.; Hicks, K.; Taddeo, S. The FASEB Journal, Vol. 29, Issue S1 https://doi.org/10.1096/fasebj.29.1_supplement.394.7	journal	April 2015

Cited By (8)

Dried Plums, Prunes and Bone Health: A Comprehensive Review Wallace, Taylor Nutrients, Vol. 9, Issue 4 https://doi.org/10.3390/nu9040401	journal	April 2017
A Moderate Daily Dose of Resveratrol Mitigates Muscle Deconditioning in a Martian Gravity Analog Mortreux, Marie; Riveros, Daniela; Bouxsein, Mary L. Frontiers in Physiology, Vol. 10 https://doi.org/10.3389/fphys.2019.00899	journal	July 2019
Radiation-Induced Bone Toxicity Okoukoni, Catherine; Farris, Michael; Hughes, Ryan T. Current Stem Cell Reports, Vol. 3, Issue 4 https://doi.org/10.1007/s40778-017-0099-z	journal	October 2017
Establishing mechanisms affecting the individual response to ionizing radiation Averbeck, Dietrich; Candéias, Serge; Chandna, Sudhir International Journal of Radiation Biology, Vol. 96, Issue 3 https://doi.org/10.1080/09553002.2019.1704908	journal	January 2020
Effects of Iron Overload and Oxidative Damage on the Musculoskeletal System in the Space Environment: Data from Spaceflights and Ground-Based Simulation Models Yang, Jiancheng; Zhang, Gejing; Dong, Dandan International Journal of Molecular Sciences, Vol. 19, Issue 9 https://doi.org/10.3390/ijms19092608	journal	September 2018
Ionizing Radiation Exacerbates the Bone Loss Induced by Iron Overload in Mice Zhang, Jian; Qiao, Penghai; Yao, Gang Biological Trace Element Research, Vol. 196, Issue 2 https://doi.org/10.1007/s12011-019-01929-7	journal	November 2019
Therapeutic ionizing radiation induced bone loss: a review of in vivo and in vitro findings Zhang, Jian; Qiu, Xinyu; Xi, Kedi Connective Tissue Research, Vol. 59, Issue 6 https://doi.org/10.1080/03008207.2018.1439482	journal	March 2018
Redox Signaling and Its Impact on Skeletal and Vascular Responses to Spaceflight Tahimic, Candice; Globus, Ruth International Journal of Molecular Sciences, Vol. 18, Issue 10 https://doi.org/10.3390/ijms18102153	journal	October 2017

Similar Records

Ionizing Radiation Stimulates Expression of Pro-Osteoclastogenic Genes in Marrow and Skeletal Tissue

Journal Article · Thu Jun 11 00:00:00 EDT 2015 · Journal of Interferon & Cytokine Research · OSTI ID:1242248

Alwood, Joshua S.; Shahnazari, Mohammad; Chicana, Betsabel; +5 more

Oxidative Stress and Skeletal Health with Low-Dose, Low-LET (Linear Energy Transfer) Ionizing Radiation

Technical Report · Mon Nov 03 00:00:00 EST 2014 · OSTI ID:1242248

Betulinic acid, a bioactive pentacyclic triterpenoid, inhibits skeletal-related events induced by breast cancer bone metastases and treatment

Journal Article · Sat Mar 01 00:00:00 EST 2014 · Toxicology and Applied Pharmacology · OSTI ID:1242248

Park, Se Young; Kim, Hyun-Jeong; Kim, Ki Rim; +4 more

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
bone
targeted bone remodelling
osteoimmunology
radiotherapy

Title: Dried plum diet protects from bone loss caused by ionizing radiation

Citation Formats

References (64)

Cited By (8)

Similar Records

Related Subjects