Cell-based composite materials with programmed structures and functions

Title: Cell-based composite materials with programmed structures and functions

Patent · Tue Mar 01 00:00:00 EST 2016

OSTI ID:1241025

The present invention is directed to the use of silicic acid to transform biological materials, including cellular architecture into inorganic materials to provide biocomposites (nanomaterials) with stabilized structure and function. In the present invention, there has been discovered a means to stabilize the structure and function of biological materials, including cells, biomolecules, peptides, proteins (especially including enzymes), lipids, lipid vesicles, polysaccharides, cytoskeletal filaments, tissue and organs with silicic acid such that these materials may be used as biocomposites. In many instances, these materials retain their original biological activity and may be used in harsh conditions which would otherwise destroy the integrity of the biological material. In certain instances, these biomaterials may be storage stable for long periods of time and reconstituted after storage to return the biological material back to its original form. In addition, by exposing an entire cell to form CSCs, the CSCs may function to provide a unique system to study enzymes or a cascade of enzymes which are otherwise unavailable.

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Research Organization:: Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC04-94AL85000

Assignee:: Sandia Corporation (Albuquerque, NM)

Patent Number(s):: 9,273,305

Application Number:: 13/869,799

OSTI ID:: 1241025

Resource Relation:: Patent File Date: 2013 Aug 24

Country of Publication:: United States

Language:: English

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Hollow sphere metal oxides Jiang, Xingmao; Brinker, Charles Jeffrey https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7744673 US Patent Document 7,744,673	patent	June 2010
Method for making surfactant-templated thin films Brinker, C. Jeffrey; Lu, Yunfeng; Fan, Hong https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/RE41612 US Patent Document RE41,612	patent	August 2010
Method of making dense, conformal, ultra-thin cap layers for nanoporous low-k ILD by plasma assisted atomic layer deposition Jiang, Ying; Cecchi, Joseph L.; Brinker, C. Jeffrey https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7947579 US Patent Document 7,947,579	patent	May 2011
Self-assembly of water-soluble nanocrystals Fan, Hongyou; Brinker, C. Jeffrey; Lopez, Gabriel P. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8092595 US Patent Document 8,092,595	patent	January 2012
Ultra-thin microporous/hybrid materials Jiang, Ying; Cecchi, Joseph L.; Brinker, C. Jeffrey https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8187678 US Patent Document 8,187,678	patent	May 2012
Aerosol method for nano silver-silica composite anti-microbial agent Jiang, Xingmao; Brinker, C. Jeffrey; Lin, Yong https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8246933 US Patent Document 8,246,933	patent	August 2012
Methods for preparing high crystallinity and surface area porous metal oxides Jiang, Xingmao; Brinker, C. Jeffrey https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8318127 US Patent Document 8,318,127	patent	November 2012
Freezing assisted fabrication of nano and micro hollow cubic metal oxides Jiang, Xingmao; Brinker, C. Jeffrey https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8501057 US Patent Document 8,501,057	patent	August 2013
Durable polymer-aerogel based superhydrophobic coatings, a composite material Kissel, David J.; Brinker, Charles Jeffrey https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8663742 US Patent Document 8,663,742	patent	March 2014
Method of Making Dense, Conformal, Ultra-Thin Cap Layers for Nanoporous Low-K ILD by Plasma Assisted Atomic Layer Deposition Jiang, Ying-Bing; Cecchi, Joseph L.; Brinker, C. Jeffrey https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20110186971 US Patent Document 13/083790; 20110186971	patent-application	August 2011
Porous Nanoparticle Supported Lipid Bilayer Nanostructures Liu, Juewen; Brinker, Jeffrey C.; Ashley, Carlee https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20110268791 US Patent Document 13/143164; 20110268791	patent-application	November 2011
Superhydrophobic Aerogel That Does Not Require Per-Fluoro Compounds or Contain Any Fluorine Kissel, David J.; Brinker, Charles Jeffrey https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20120040577 US Patent Document 13/121166; 20120040577	patent-application	February 2012

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