A method for modeling oxygen diffusion in an agent-based model with application to host-pathogen infection
- Univ. of Houston, Houston, TX (United States)
This paper describes a method for incorporating a diffusion field modeling oxygen usage and dispersion in a multi-scale model of Mycobacterium tuberculosis (Mtb) infection mediated granuloma formation. We implemented this method over a floating-point field to model oxygen dynamics in host tissue during chronic phase response and Mtb persistence. The method avoids the requirement of satisfying the Courant-Friedrichs-Lewy (CFL) condition, which is necessary in implementing the explicit version of the finite-difference method, but imposes an impractical bound on the time step. Instead, diffusion is modeled by a matrix-based, steady state approximate solution to the diffusion equation. Moreover, presented in figure 1 is the evolution of the diffusion profiles of a containment granuloma over time.
- Research Organization:
- Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
- Sponsoring Organization:
- USDOE National Nuclear Security Administration (NNSA)
- Grant/Contract Number:
- AC04-94AL85000
- OSTI ID:
- 1237360
- Report Number(s):
- SAND-2015-0080J; 558360
- Journal Information:
- IEEE Engineering in Medicine and Biology. Annual Conference, Vol. 2014; Conference: Engineering in Medicince and Biology Society (EMBC), 2014 36th Annual Conference, Chicago, IL (United States), 26-30 Aug 2014; ISSN 1557-170X
- Publisher:
- IEEECopyright Statement
- Country of Publication:
- United States
- Language:
- English
Oxygen Modulates the Effectiveness of Granuloma Mediated Host Response to Mycobacterium tuberculosis: A Multiscale Computational Biology Approach
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journal | February 2016 |
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