Slow light Mach-Zehnder interferometer as label-free biosensor with scalable sensitivity

Qin, Kun; Hu, Shuren; Retterer, Scott T.; Kravchenko, Ivan I.; Weiss, Sharon M.

doi:10.1364/OL.41.000753

Title: Slow light Mach-Zehnder interferometer as label-free biosensor with scalable sensitivity

Journal Article · Fri Feb 05 00:00:00 EST 2016 · Optics Letters

DOI:https://doi.org/10.1364/OL.41.000753· OSTI ID:1237162

Qin, Kun ^[1]; Hu, Shuren ^[1]; Retterer, Scott T. ^[2]; Kravchenko, Ivan I. ^[2]; Weiss, Sharon M. ^[1]

Vanderbilt Univ., Nashville, TN (United States)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

Our design, fabrication, and characterization of a label-free Mach–Zehnder interferometer (MZI) optical biosensor that incorporates a highly dispersive one-dimensional (1D) photonic crystal in one arm are presented. The sensitivity of this slow light MZI-based sensor scales with the length of the slow light photonic crystal region. The numerically simulated sensitivity of a MZI sensor with a 16 μm long slow light region is 115,000 rad/RIU-cm, which is sevenfold higher than traditional MZI biosensors with millimeter-length sensing regions. Moreover, the experimental bulk refractive index detection sensitivity of 84,000 rad/RIU-cm is realized and nucleic acid detection is also demonstrated.

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Research Organization:: Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1237162

Journal Information:: Optics Letters, Vol. 41, Issue 4; ISSN 0146-9592

Publisher:: Optical Society of America (OSA)Copyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 46 works

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Human heart failure biomarker immunosensor based on excessively tilted fiber gratings Luo, Binbin; Wu, Shengxi; Zhang, Zhonghao Biomedical Optics Express, Vol. 8, Issue 1 https://doi.org/10.1364/boe.8.000057	journal	December 2016
High sensitivity and label-free oligonucleotides detection using photonic bandgap sensing structures biofunctionalized with molecular beacon probes Ruiz-Tórtola, Ángela; Prats-Quílez, Francisco; González-Lucas, Daniel Biomedical Optics Express, Vol. 9, Issue 4 https://doi.org/10.1364/boe.9.001717	journal	January 2018
Improving the detection limit for on-chip photonic sensors based on subwavelength grating racetrack resonators Huang, Lijun; Yan, Hai; Xu, Xiaochuan Optics Express, Vol. 25, Issue 9 https://doi.org/10.1364/oe.25.010527	journal	January 2017
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Fundamental limit of detection of photonic biosensors with coherent phase read-out Molina-Fernández, Íñigo; Leuermann, Jonas; Ortega-Moñux, Alejandro Optics Express, Vol. 27, Issue 9 https://doi.org/10.1364/oe.27.012616	journal	January 2019
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