Compositions containing amino acids, phosphate and manganese and their uses

Daly, Michael J.; Gaidamakova, Elena K.

Title: Compositions containing amino acids, phosphate and manganese and their uses

Patent · Tue Jan 12 00:00:00 EST 2016

OSTI ID:1234646

Daly, Michael J.; Gaidamakova, Elena K.

The invention provides methods of producing vaccines directed against microorganisms, with the methods comprising culturing, harvesting and/or suspending the microorganism in the presence of a radiation-protective composition and irradiating the bacteria or viruses with a dose of radiation sufficient to render the microorganism replication-deficient and/or non-infective. The radiation-protective compositions used in the methods of the present invention comprise at least one nucleoside, at least one antioxidant and at least one small peptide. The invention also provides methods of rendering bacteria in culture resistant to ionizing radiation (IR), with these methods comprising culturing the bacteria in the presence of a radiation-protective composition.

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Research Organization:: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: FG02-04ER63918

Assignee:: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, MD)

Patent Number(s):: 9,234,168

Application Number:: 13/643,794

OSTI ID:: 1234646

Resource Relation:: Patent File Date: 2011 Apr 29

Country of Publication:: United States

Language:: English

References (24)

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Accumulation of Mn(II) in Deinococcus radiodurans Facilitates Gamma-Radiation Resistance Daly, M. J.; Gaidamakova, E. K.; Matrosova, V. Y. Science, Vol. 306, Issue 5698, p. 1025-1028 https://doi.org/10.1126/science.1103185	journal	November 2004
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