Distinct tumor suppressor mechanisms evolve in rodent species that differ in size and lifespan
|
journal
|
December 2008 |
In situ analyses of genome instability in breast cancer
|
journal
|
August 2004 |
Inactivation of p53 Function in Cultured Human Mammary Epithelial Cells Turns the Telomere-Length Dependent Senescence Barrier from Agonescence into Crisis
|
journal
|
August 2007 |
Induction of transformation and continuous cell lines from normal human mammary epithelial cells after exposure to benzo[a]pyrene.
|
journal
|
April 1985 |
Loss of p53 function accelerates acquisition of telomerase activity in indefinite lifespan human mammary epithelial cell lines
|
journal
|
August 2003 |
Molecular Distinctions between Stasis and Telomere Attrition Senescence Barriers Shown by Long-term Culture of Normal Human Mammary Epithelial Cells
|
journal
|
September 2009 |
Raf-1-induced growth arrest in human mammary epithelial cells is p16-independent and is overcome in immortal cells during conversion
|
journal
|
September 2002 |
Increased p16 expression with first senescence arrest in human mammary epithelial cells and extended growth capacity with p16 inactivation
|
journal
|
July 1998 |
Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes
|
journal
|
February 2001 |
Gradual Phenotypic Conversion Associated with Immortalization of Cultured Human Mammary Epithelial Cells
|
journal
|
December 1997 |
Oncogenes induce senescence with incomplete growth arrest and suppress the DNA damage response in immortalized cells: Oncogenes induce atypical senescence phenotype
|
journal
|
September 2011 |
Breast Cancer: Cellular and Molecular Biology
|
book
|
January 1988 |
Serum-free growth of human mammary epithelial cells: rapid clonal growth in defined medium and extended serial passage with pituitary extract.
|
journal
|
September 1984 |
Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells
|
journal
|
November 1998 |
Expression of the telomerase catalytic subunit, hTERT, induces resistance to transforming growth factor β growth inhibition in p16INK4A(−) human mammary epithelial cells
|
journal
|
April 2001 |
Viral oncogenes accelerate conversion to immortality of cultured conditionally immortal human mammary epithelial cells
|
journal
|
April 1999 |
MYC on the Path to Cancer
|
journal
|
March 2012 |
Differential Effects on ARF Stability by Normal versus Oncogenic Levels of c-Myc Expression
|
journal
|
July 2013 |
Distinct Thresholds Govern Myc's Biological Output In Vivo
|
journal
|
December 2008 |
Genomic and transcriptional aberrations linked to breast cancer pathophysiologies
|
journal
|
December 2006 |
In Brief
|
journal
|
October 2009 |
A Chromatin Landmark and Transcription Initiation at Most Promoters in Human Cells
|
journal
|
July 2007 |
Cell type-specific DNA methylation patterns in the human breast
|
journal
|
September 2008 |
Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype
|
journal
|
February 2010 |
A Two-Stage, p16INK4A- and p53-Dependent Keratinocyte Senescence Mechanism That Limits Replicative Potential Independent of Telomere Status
|
journal
|
July 2002 |
The alternative lengthening of telomeres phenotype in breast carcinoma is associated with HER-2 overexpression
|
journal
|
September 2009 |
Early Telomere Shortening and Genomic Instability in Tubo-Ovarian Preneoplastic Lesions
|
journal
|
April 2013 |
Telomerase beyond telomeres
|
journal
|
August 2002 |
Differential cis-regulation of human versus mouse TERT gene expression in vivo: Identification of a human-specific repressive element
|
journal
|
December 2005 |
Telomere dysfunction provokes regional amplification and deletion in cancer genomes
|
journal
|
August 2002 |
p16 INK4a Modulates p53 in Primary Human Mammary Epithelial Cells
|
journal
|
November 2006 |
Defining the cellular precursors to human breast cancer
|
journal
|
September 2011 |
Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers
|
journal
|
August 2009 |
BRCA1 Basal-like Breast Cancers Originate from Luminal Epithelial Progenitors and Not from Basal Stem Cells
|
journal
|
September 2010 |
Genetic Predisposition Directs Breast Cancer Phenotype by Dictating Progenitor Cell Fate
|
journal
|
February 2011 |
Accumulation of Multipotent Progenitors with a Basal Differentiation Bias during Aging of Human Mammary Epithelia
|
journal
|
May 2012 |
The Genomic Landscapes of Human Breast and Colorectal Cancers
|
journal
|
November 2007 |
Human cancers express mutator phenotypes: origin, consequences and targeting
|
journal
|
May 2011 |
Genomic instability — an evolving hallmark of cancer
|
journal
|
March 2010 |
Aneuploidy Drives a Mutator Phenotype in Cancer
|
journal
|
August 2011 |
From polyploidy to aneuploidy, genome instability and cancer
|
journal
|
January 2004 |
Telomere dysfunction drives chromosomal instability in human mammary epithelial cells
|
journal
|
December 2005 |
Progressive Telomere Dysfunction Causes Cytokinesis Failure and Leads to the Accumulation of Polyploid Cells
|
journal
|
April 2012 |
Tumour markers in breast carcinoma correlate with grade rather than with invasiveness
|
journal
|
September 2001 |
PIK3CA Mutations in In situ and Invasive Breast Carcinomas
|
journal
|
June 2010 |
Gene expression profiles of human breast cancer progression
|
journal
|
April 2003 |
What is the malignant nature of human ductal carcinoma in situ?
|
journal
|
December 2010 |
TGF- signaling engages an ATM-CHK2-p53-independent RAS-induced senescence and prevents malignant transformation in human mammary epithelial cells
|
journal
|
May 2011 |
hTERT Is Expressed in Cancer Cell Lines Despite Promoter DNA Methylation by Preservation of Unmethylated DNA and Active Chromatin around the Transcription Start Site
|
journal
|
January 2007 |
BORIS/CTCFL-mediated transcriptional regulation of the hTERT telomerase gene in testicular and ovarian tumor cells
|
journal
|
September 2010 |
Rb-Mediated Heterochromatin Formation and Silencing of E2F Target Genes during Cellular Senescence
|
journal
|
June 2003 |
Chimaeras of Myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells
|
journal
|
July 1989 |
Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization
|
journal
|
December 1998 |
Epigenetic regulation of normal human mammary cell type-specific miRNAs
|
journal
|
August 2011 |
Telomeres, telomerase and senescence
|
journal
|
August 1990 |
miR-145, miR-205 and miR-451: potential tumor suppressors involved in the progression of in situ to invasive carcinoma of the breast
|
journal
|
April 2022 |
Telomere Shortening Occurs Early During Breast Tumorigenesis: A Cause of Chromosome Destabilization Underlying Malignant Transformation?
|
journal
|
July 2004 |
Mechanisms of Polycomb gene silencing: knowns and unknowns
|
journal
|
September 2009 |
Comparative transcriptional analyses of preclinical models and patient samples reveal MYC and RELA driven expression patterns that define the molecular landscape of IBC
|
journal
|
January 2022 |
The replicometer is broken: telomeres activate cellular senescence in response to genotoxic stresses
|
journal
|
July 2014 |
Stepwise DNA Methylation Changes Are Linked to Escape from Defined Proliferation Barriers and Mammary Epithelial Cell Immortalization
|
journal
|
June 2009 |
Early Telomere Shortening and Genomic Instability in Tubo-Ovarian Preneoplastic Lesions—Response
|
journal
|
September 2013 |
The role of genetic diversity in cancer
|
journal
|
February 2010 |