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Title: Fiber optical asssembly for fluorescence spectrometry

Patent ·
OSTI ID:1210861

System is provided for detecting the presence of an analyte of interest in a sample, said system comprising an elongated, transparent container for a sample; an excitation source in optical communication with the sample, wherein radiation from the excitation source is directed along the length of the sample, and wherein the radiation induces a signal which is emitted from the sample; and, at least two linear arrays disposed about the sample holder, each linear array comprising a plurality of optical fibers having a first end and a second end, wherein the first ends of the fibers are disposed along the length of the container and in proximity thereto; the second ends of the fibers of each array are bundled together to form a single end port.

Research Organization:
Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC52-06NA25396
Assignee:
Los Alamos National Security, LLC (Los Alamos, NM)
Patent Number(s):
9,110,024
Application Number:
13/258,727
OSTI ID:
1210861
Resource Relation:
Patent File Date: 2010 Mar 25
Country of Publication:
United States
Language:
English

References (46)

Flow cytometer patent October 1987
Apparatus and method for detecting chemiluminescent light patent February 1998
Method and devices for laser induced fluorescence attenuation spectroscopy patent September 2000
Method and apparatus for producing and measuring light and for determining the amounts of analytes in microplate wells patent March 2003
Antibodies to a YYX epitope of a mammalian prion protein patent May 2006
Dual beam FTIR methods and devices for use in analyte detection in samples of low transmissivity patent July 2006
Device and method for multiparametric analysis of microscopic elements patent August 2010
Fiber optical assembly for fluorescence spectrometry patent December 2010
Simplified ultrasensitive prion detection by recombinant PrP conversion with shaking journal March 2008
Autocatalytic self-propagation of misfolded prion protein journal August 2004
Conservation of infectivity in purified fibrillary extracts of scrapie-infected hamster brain after sequential enzymatic digestion or polyacrylamide gel electrophoresis. journal September 1990
Normal prion protein has an activity like that of superoxide dismutase journal November 1999
Detection of prions in blood journal August 2005
In Vitro Generation of Infectious Scrapie Prions journal April 2005
PrP antibody binding-induced epitope modulation evokes immunocooperativity journal December 2008
Surround optical fiber immunoassay (SOFIA): An ultra-sensitive assay for prion protein detection journal July 2009
Protease-resistant Prion Protein Amplification Reconstituted with Partially Purified Substrates and Synthetic Polyanions journal May 2005
Diagnosis of Transmissible Spongiform Encephalopathies in Animals: A Review journal November 2005
Role of lymph-borne cells in the early stages of scrapie agent dissemination from the skin journal February 2006
Detection of CWD Prions in Urine and Saliva of Deer by Transgenic Mouse Bioassay journal March 2009
Detection of Sub-Clinical CWD Infection in Conventional Test-Negative Deer Long after Oral Exposure to Urine and Feces from CWD+ Deer journal November 2009
A rapid and efficient method to enrich SAF-protein from scrapie brains of hamsters journal February 1984
In vitro amplification and detection of variant Creutzfeldt–Jakob disease PrPSc journal January 2007
Preferential Cu 2+ Coordination by His 96 and His 111 Induces β-Sheet Formation in the Unstructured Amyloidogenic Region of the Prion Protein journal May 2004
Guanidine hydrochloride extraction and detection of prion proteins in mouse and hamster prion diseases by ELISA journal January 2003
Comparison of PrP transcription and translation in two murine myeloma cell lines journal July 2003
Cell-free formation of protease-resistant prion protein journal August 1994
Efficient In Vitro Amplification of Chronic Wasting Disease PrPRES journal June 2007
Passage of chronic wasting disease prion into transgenic mice expressing Rocky Mountain elk (Cervus elaphus nelsoni) PrPC journal December 2006
Characterization of prion protein (PrP)-derived peptides that discriminate full-length PrPSc from PrPC journal June 2007
Abnormal prion protein in genetically resistant sheep from a scrapie-infected flock journal November 2004
Infectious Prions in Pre-Clinical Deer and Transmission of Chronic Wasting Disease Solely by Environmental Exposure journal June 2009
Infectious Prions in the Saliva and Blood of Deer with Chronic Wasting Disease journal October 2006
Urinary excretion and blood level of prions in scrapie-infected hamsters journal October 2007
Preclinical vCJD after blood transfusion in a PRNP codon 129 heterozygous patient journal August 2004
Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication journal November 1990
Evidence of a molecular barrier limiting susceptibility of humans, cattle and sheep to chronic wasting disease journal September 2000
Concentration and distribution of infectivity and PrPSc following partial denaturation of a mouse-adapted and a hamster-adapted scrapie strain journal September 1994
Presymptomatic Detection of Prions in Blood journal July 2006
Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding journal June 2001
Pre-symptomatic detection of prions by cyclic amplification of protein misfolding journal December 2004
Asymptomatic deer excrete infectious prions in faeces journal September 2009
Disease-Associated Prion Protein Elicits Immunoglobulin M Responses In Vivo journal July 2004
In vitro amplification of PrPSc derived from the brain and blood of sheep infected with scrapie journal December 2008
Immumohistochemical Detection and Localization of Prion Protein in Brain Tissue of Sheep With Natural Scrapie journal May 1995
PrPCWD in rectal lymphoid tissue of deer (Odocoileus spp.) journal July 2007