Collisions of deformable cells lead to collective migration

Löber, Jakob; Ziebert, Falko; Aranson, Igor S.

doi:10.1038/srep09172

Title: Collisions of deformable cells lead to collective migration

Journal Article · Tue Mar 17 00:00:00 EDT 2015 · Scientific Reports

DOI:https://doi.org/10.1038/srep09172· OSTI ID:1201501

Löber, Jakob ^[1]; Ziebert, Falko ^[2]; Aranson, Igor S. ^[3]

Technische Universitat Berlin (Germany). Inst. fur Theoretische Physik.
Albert-Ludwigs-Universitat Freiburg (Germany). Physikalisches Institut; Institut Charles Sadron, Strasbourg Cedex (France)
Argonne National Lab. (ANL), Argonne, IL (United States); Northwestern Univ., Evanston, IL (United States). Engineering Sciences and Applied Mathematics.

Collective migration of eukaryotic cells plays a fundamental role in tissue growth, wound healing and immune response. The motion, arising spontaneously or in response to chemical and mechanical stimuli, is also important for understanding life-threatening pathologies, such as cancer and metastasis formation. We present a phase-field model to describe the movement of many self-organized, interacting cells. The model takes into account the main mechanisms of cell motility – acto-myosin dynamics, as well as substrate-mediated and cell-cell adhesion. It predicts that collective cell migration emerges spontaneously as a result of inelastic collisions between neighboring cells: collisions lead to a mutual alignment of the cell velocities and to the formation of coherently-moving multi-cellular clusters. Small cell-to-cell adhesion, in turn, reduces the propensity for large-scale collective migration, while higher adhesion leads to the formation of moving bands. Our study provides valuable insight into biological processes associated with collective cell motility.

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Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES); German Research Foundation (DFG); USDOE Office of Science - Office of Basic Energy Sciences - Materials Sciences and Engineering Division

Grant/Contract Number:: AC02-06CH11357

OSTI ID:: 1201501

Alternate ID(s):: OSTI ID: 1392522

Journal Information:: Scientific Reports, Vol. 5, Issue 1; ISSN 2045-2322

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

Citation Metrics:

Cited by: 110 works

Citation information provided by
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