skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Current Strategic Thinking for the Development of a Trivalent Alphavirus Vaccine for Human Use

Journal Article · · The American Journal of Tropical Medicine & Hygiene, vol. 91, no. 3, May 19, 2014, pp. 442

Research Organization:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
DE-AC52-07NA27344
OSTI ID:
1188625
Report Number(s):
LLNL-JRNL-648643
Journal Information:
The American Journal of Tropical Medicine & Hygiene, vol. 91, no. 3, May 19, 2014, pp. 442, Journal Name: The American Journal of Tropical Medicine & Hygiene, vol. 91, no. 3, May 19, 2014, pp. 442
Country of Publication:
United States
Language:
English

References (45)

Vaccines for Venezuelan equine encephalitis journal November 2009
A structural and functional perspective of alphavirus replication and assembly journal September 2009
Encephalitic alphaviruses journal January 2010
Medically important arboviruses of the United States and Canada. journal January 1994
Arbovirus Isolations from Mosquitoes Collected during and after the 1982–1983 Epizootic of Western Equine Encephalitis in Argentina journal January 1987
Western equine encephalitis virus is a recombinant virus. journal August 1988
Reevaluation of the Western Equine Encephalitis Antigenic Complex of Alphaviruses (Family Togaviridae) as Determined by Neutralization Tests journal March 1988
Recombinational history and molecular evolution of western equine encephalomyelitis complex alphaviruses. journal January 1997
Western Equine Encephalomyelitis: Virulence Markers and Their Epidemiologic Significance journal September 1993
Infectivity variation and genetic diversity among strains of Western equine encephalitis virus journal August 2006
Genetic and antigenic diversity among eastern equine encephalitis viruses from North, Central, and South America. journal October 1999
Evolutionary Patterns of Eastern Equine Encephalitis Virus in North versus South America Suggest Ecological Differences and Taxonomic Revision journal November 2009
Eastern Equine Encephalitis in Latin America journal August 2013
Positively Charged Amino Acid Substitutions in the E2 Envelope Glycoprotein Are Associated with the Emergence of Venezuelan Equine Encephalitis Virus journal February 2002
Alphaviruses: Population genetics and determinants of emergence journal June 2012
Epidemic Venezuelan Equine Encephalitis in La Guajira, Colombia, 1995 journal April 1997
Laboratory-associated infections and biosafety. journal July 1995
Chemical and Biological Warfare book January 2002
Experimental Infection of Horses with Enzootic and Epizootic Strains of Venezuelan Equine Encephalomyelitis Virus journal September 1973
Experimental Infection of Horses with an Attenuated Venezuelan Equine Encephalomyelitis Vaccine (Strain TC-83) journal January 1972
Attenuated Mutants of Venezuelan Equine Encephalitis Virus Containing Lethal Mutations in the PE2 Cleavage Signal Combined with a Second-Site Suppressor Mutation in E1 journal September 1995
Venezuelan equine encephalitis virus vaccine candidate (V3526) safety, immunogenicity and efficacy in horses journal February 2007
Comparison of the immunological responses and efficacy of gamma-irradiated V3526 vaccine formulations against subcutaneous and aerosol challenge with Venezuelan equine encephalitis virus subtype IAB journal January 2010
Immune interference after sequential alphavirus vaccine vaccinations journal August 2009
Long-term duration of detectable neutralizing antibodies after administration of live-attenuated VEE vaccine and following booster vaccination with inactivated VEE vaccine journal March 1996
Immune interference in the setting of same-day administration of two similar inactivated alphavirus vaccines: Eastern equine and western equine encephalitis journal November 2012
IRES-driven Expression of the Capsid Protein of the Venezuelan Equine Encephalitis Virus TC-83 Vaccine Strain Increases Its Attenuation and Safety journal May 2013
A DNA Vaccine for Venezuelan Equine Encephalitis Virus Delivered by Intramuscular Electroporation Elicits High Levels of Neutralizing Antibodies in Multiple Animal Models and Provides Protective Immunity to Mice and Nonhuman Primates journal March 2011
Safety and protective efficacy of INA-inactivated Venezuelan equine encephalitis virus: Implication in vaccine development journal January 2011
A multisystem approach for development and evaluation of inactivated vaccines for Venezuelan equine encephalitis virus (VEEV) journal February 2010
A virus-like particle vaccine for epidemic Chikungunya virus protects nonhuman primates against infection journal January 2010
A Single-Site Mutant and Revertants Arising in Vivo Define Early Steps in the Pathogenesis of Venezuelan Equine Encephalitis Virus journal April 2000
Spread of Venezuelan equine encephalitis virus in mice olfactory tract journal December 1995
Early Events in the Pathogenesis of Eastern Equine Encephalitis Virus in Mice journal January 2005
REVIEW PAPER: Pathology of Animal Models of Alphavirus Encephalitis journal June 2010
Severe Encephalitis in Cynomolgus Macaques Exposed to Aerosolized Eastern Equine Encephalitis Virus journal August 2007
Aerosol Exposure to Western Equine Encephalitis Virus Causes Fever and Encephalitis in Cynomolgus Macaques journal October 2005
Arbovirus evolution in vivo is constrained by host alternation journal May 2008
Differential accumulation of genetic and phenotypic changes in Venezuelan equine encephalitis virus and Japanese encephalitis virus following passage in vitro and in vivo journal June 2011
Mutations in the E2 Glycoprotein of Venezuelan Equine Encephalitis Virus Confer Heparan Sulfate Interaction, Low Morbidity, and Rapid Clearance from Blood of Mice journal October 2000
Molecular Determinants of Mouse Neurovirulence and Mosquito Infection for Western Equine Encephalitis Virus journal March 2013
When Whole-Genome Alignments Just Won't Work: kSNP v2 Software for Alignment-Free SNP Discovery and Phylogenetics of Hundreds of Microbial Genomes journal December 2013
SNP-Associations and Phenotype Predictions from Hundreds of Microbial Genomes without Genome Alignments journal February 2014
Licensure of vaccines using the Animal Rule journal June 2012
Complex Correlates of Protection After Vaccination journal February 2013

Similar Records

Deinococcus Mn2+-peptide complex: A novel approach to alphavirus vaccine development
Journal Article · Thu Jun 01 00:00:00 EDT 2017 · Vaccine · OSTI ID:1188625

Analysis of Trivalent Cation Complexation to Functionalized Mesoporous Silica using Solid-State NMR Spectroscopy
Journal Article · Fri Mar 28 00:00:00 EDT 2014 · Dalton Transactions, vol. 43, no. 44, October 22, 2014, pp. 16649-16658 · OSTI ID:1188625

Producing physicochemical property consensus alphavirus protein antigens for broad spectrum vaccine design
Journal Article · Thu Oct 01 00:00:00 EDT 2020 · Antiviral Research · OSTI ID:1188625

Related Subjects