Nano-gold corking and enzymatic uncorking of carbon nanotube cups
Abstract
Because of their unique stacked, cup-shaped, hollow compartments, nitrogen-doped carbon nanotube cups (NCNCs) have promising potential as nanoscale containers. Individual NCNCs are isolated from their stacked structure through acid oxidation and subsequent probe-tip sonication. The NCNCs are then effectively corked with gold nanoparticles (GNPs) by sodium citrate reduction with chloroauric acid, forming graphitic nanocapsules with significant surface-enhanced Raman signature. Mechanistically, the growth of the GNP corks starts from the nucleation and welding of gold seeds on the open rims of NCNCs enriched with nitrogen functionalities, as confirmed by density functional theory calculations. A potent oxidizing enzyme of neutrophils, myeloperoxidase (MPO), can effectively open the corked NCNCs through GNP detachment, with subsequent complete enzymatic degradation of the graphitic shells. Lastly, this controlled opening and degradation was further carried out in vitro with human neutrophils. In addition, the GNP-corked NCNCs were demonstrated to function as novel drug delivery carriers, capable of effective (i) delivery of paclitaxel to tumor-associated myeloid-derived suppressor cells (MDSC), (ii) MPO-regulated release, and (iii) blockade of MDSC immunosuppressive potential.
- Authors:
-
- Univ. of Pittsburgh, Pittsburgh, PA (United States)
- National Energy Technology Lab. (NETL), Pittsburgh, PA, (United States)
- Univ. of Pittsburgh Medical Center, Pittsburgh, PA (United States)
- Publication Date:
- Research Org.:
- National Energy Technology Lab. (NETL), Pittsburgh, PA, (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1186638
- Report Number(s):
- A-UNIV-PUB-122
Journal ID: ISSN 0002-7863
- Grant/Contract Number:
- 0954345; R01CA154369; R01ES019304; NIOSH OH008282; HL114453; U19 AI068021
- Resource Type:
- Journal Article: Accepted Manuscript
- Journal Name:
- Journal of the American Chemical Society
- Additional Journal Information:
- Journal Volume: 137; Journal Issue: 2; Journal ID: ISSN 0002-7863
- Publisher:
- American Chemical Society (ACS)
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 36 MATERIALS SCIENCE; 60 APPLIED LIFE SCIENCES; 59 BASIC BIOLOGICAL SCIENCES; 77 NANOSCIENCE AND NANOTECHNOLOGY
Citation Formats
Zhao, Yong, Burkert, Seth C., Tang, Yifan, Sorescu, Dan C., Kapralov, Alexandr A., Shurin, Galina V., Shurin, Michael R., Kagan, Valerian E., and Star, Alexander. Nano-gold corking and enzymatic uncorking of carbon nanotube cups. United States: N. p., 2014.
Web. doi:10.1021/ja511843w.
Zhao, Yong, Burkert, Seth C., Tang, Yifan, Sorescu, Dan C., Kapralov, Alexandr A., Shurin, Galina V., Shurin, Michael R., Kagan, Valerian E., & Star, Alexander. Nano-gold corking and enzymatic uncorking of carbon nanotube cups. United States. https://doi.org/10.1021/ja511843w
Zhao, Yong, Burkert, Seth C., Tang, Yifan, Sorescu, Dan C., Kapralov, Alexandr A., Shurin, Galina V., Shurin, Michael R., Kagan, Valerian E., and Star, Alexander. 2014.
"Nano-gold corking and enzymatic uncorking of carbon nanotube cups". United States. https://doi.org/10.1021/ja511843w. https://www.osti.gov/servlets/purl/1186638.
@article{osti_1186638,
title = {Nano-gold corking and enzymatic uncorking of carbon nanotube cups},
author = {Zhao, Yong and Burkert, Seth C. and Tang, Yifan and Sorescu, Dan C. and Kapralov, Alexandr A. and Shurin, Galina V. and Shurin, Michael R. and Kagan, Valerian E. and Star, Alexander},
abstractNote = {Because of their unique stacked, cup-shaped, hollow compartments, nitrogen-doped carbon nanotube cups (NCNCs) have promising potential as nanoscale containers. Individual NCNCs are isolated from their stacked structure through acid oxidation and subsequent probe-tip sonication. The NCNCs are then effectively corked with gold nanoparticles (GNPs) by sodium citrate reduction with chloroauric acid, forming graphitic nanocapsules with significant surface-enhanced Raman signature. Mechanistically, the growth of the GNP corks starts from the nucleation and welding of gold seeds on the open rims of NCNCs enriched with nitrogen functionalities, as confirmed by density functional theory calculations. A potent oxidizing enzyme of neutrophils, myeloperoxidase (MPO), can effectively open the corked NCNCs through GNP detachment, with subsequent complete enzymatic degradation of the graphitic shells. Lastly, this controlled opening and degradation was further carried out in vitro with human neutrophils. In addition, the GNP-corked NCNCs were demonstrated to function as novel drug delivery carriers, capable of effective (i) delivery of paclitaxel to tumor-associated myeloid-derived suppressor cells (MDSC), (ii) MPO-regulated release, and (iii) blockade of MDSC immunosuppressive potential.},
doi = {10.1021/ja511843w},
url = {https://www.osti.gov/biblio/1186638},
journal = {Journal of the American Chemical Society},
issn = {0002-7863},
number = 2,
volume = 137,
place = {United States},
year = {Sun Dec 21 00:00:00 EST 2014},
month = {Sun Dec 21 00:00:00 EST 2014}
}
Web of Science
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