skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Methods and kits for predicting a response to an erythropoietic agent

Patent ·
OSTI ID:1184560

Methods for predicting a response to an erythropoietic agent in a subject include providing a biological sample from the subject, and determining an amount in the sample of at least one peptide selected from the group consisting of SEQ ID NOS: 1-17. If there is a measurable difference in the amount of the at least one peptide in the sample, when compared to a control level of the same peptide, the subject is then predicted to have a good response or a poor response to the erythropoietic agent. Kits for predicting a response to an erythropoietic agent are further provided and include one or more antibodies, or fragments thereof, that specifically recognize a peptide of SEQ ID NOS: 1-17.

Research Organization:
University of Louisville Research Foundation, Inc., Louisville, KY (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
FG02-05ER64060
Assignee:
University of Louisville Research Foundation, Inc. (Louisville, KY)
Patent Number(s):
9,057,731
Application Number:
13/167,478
OSTI ID:
1184560
Country of Publication:
United States
Language:
English

References (30)

Method for automatic dosing of drugs patent May 2000
Method and system for use in treating a patient with any drug to optimize therapy and prevent an adverse drug patent July 2001
Method and apparatus for use in treating a patient with any drug to optimize therapy and prevent an adverse drug patent June 2003
Neural network drug dosage estimation patent December 2003
Pharmacokinetic and pharmacodynamic modeling of erythropoietin administration patent June 2004
Systems and methods for medication monitoring patent November 2004
Method and apparatus for dosing single and multi-agent therapy patent April 2005
Erythropoietin dosing regimen for treating anemia patent June 2007
Method and apparatus for glucose control and insulin dosing for diabetics patent January 2010
Erythropoietic therapy for the treatment of anemia in patients with cancer: a valuable clinical and economic option journal December 2006
Anemia of inflammation: the cytokine-hepcidin link journal May 2004
Specificity of interactions of galectin-3 with Chrp, a cysteine- and histidine-rich cytoplasmic protein journal February 2003
Oncostatin M Regulates the Synthesis and Turnover of gp130, Leukemia Inhibitory Factor Receptor α, and Oncostatin M Receptor β by Distinct Mechanisms journal October 2001
Inflammatory Markers and Platelet Aggregation Tests as Predictors of Hemoglobin and Endogenous Erythropoietin Levels in Hemodialysis Patients journal January 2002
Expression of short-form oncostatin M receptor as a decoy receptor in lung adenocarcinomas journal July 2008
Model Predictive Control of Erythropoietin Administration in the Anemia of ESRD journal January 2008
Role of cytokines in the response to erythropoietin in hemodialysis patients journal October 1998
Soluble Erythropoietin Receptor Contributes to Erythropoietin Resistance in End-Stage Renal Disease journal February 2010
Precision proteomics: The case for high resolution and high mass accuracy journal September 2008
Cellular Cholesterol Depletion Triggers Shedding of the Human Interleukin-6 Receptor by ADAM10 and ADAM17 (TACE) journal June 2003
Signals for stress erythropoiesis are integrated via an erythropoietin receptor-phosphotyrosine-343-Stat5 axis journal March 2006
Interaction of a novel cysteine and histidine-rich cytoplasmic protein with galectin-3 in a carbohydrate-independent manner journal March 2000
Proteomic analysis of renal calculi indicates an important role for inflammatory processes in calcium stone formation journal October 2008
Dual Oncostatin M (OSM) Receptors: Cloning And Characterization Of An Alternative Signaling Subunit Conferring OSM-Specific Receptor Activation journal December 1996
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin journal May 2004
Targeted disruption of oncostatin M receptor results in altered hematopoiesis journal November 2003
Mechanisms of Disease: erythropoietin resistance in patients with both heart and kidney failure journal January 2008
Hypoxia-inducible factor 1α is up-regulated by oncostatin M and participates in oncostatin M signaling journal March 2009
Secondary analysis of the CHOIR trial epoetin-α dose and achieved hemoglobin outcomes journal September 2008
Epoetin requirements predict mortality in hemodialysis patients journal November 2004

Similar Records

Methods and kits for predicting a response to an erythropoietic agent
Patent · Tue Aug 07 00:00:00 EDT 2018 · OSTI ID:1184560

Enzyme-linked immunosorbent assay for detection of organophosphorylated butyrylcholinesterase: A biomarker of exposure to organophosphate agents
Journal Article · Thu May 05 00:00:00 EDT 2011 · Analytica Chimica Acta, 693(1-2):1-6 · OSTI ID:1184560

Semiquantitative measure of immune responses against erythropoietic stem cell antigens
Journal Article · Thu Jan 01 00:00:00 EST 1987 · Immunogenetics (N.Y.); (United States) · OSTI ID:1184560