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Title: Array-based detection of genetic alterations associated with disease

Patent ·
OSTI ID:1176177
; ;

The present invention relates to DNA sequences from regions of copy number change on chromosome 20. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases.

Research Organization:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC03-76SF00098
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Number(s):
7,267,947
Application Number:
10/198,805
OSTI ID:
1176177
Resource Relation:
Patent File Date: 2002 Jul 19
Country of Publication:
United States
Language:
English

References (6)

Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors journal October 1992
Comparative genomic hybridisation of ductal carcinoma in situ of the breast: identification of regions of DNA amplification and deletion in common with invasive breast carcinoma journal March 1997
Co-amplification of erbB2, topoisomerase II α and retinoic acid receptor α genes in breast cancer and allelic loss at topoisomerase I on chromosome 20 journal January 1993
Molecular heterogeneity at the breakpoints of smaller 20q deletions journal September 1994
High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays journal October 1998
Induction of mammary epithelial hyperplasias and mammary tumors in transgenic mice expressing a murine mammary tumor virus/activated c-src fusion gene. journal August 1995

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59 BASIC BIOLOGICAL SCIENCES
60 APPLIED LIFE SCIENCES