Zero-mode waveguides
The present invention is directed to a method and an apparatus for analysis of an analyte. The method involves providing a zero-mode waveguide which includes a cladding surrounding a core where the cladding is configured to preclude propagation of electromagnetic energy of a frequency less than a cutoff frequency longitudinally through the core of the zero-mode waveguide. The analyte is positioned in the core of the zero-mode waveguide and is then subjected, in the core of the zero-mode waveguide, to activating electromagnetic radiation of a frequency less than the cut-off frequency under conditions effective to permit analysis of the analyte in an effective observation volume which is more compact than if the analysis were carried out in the absence of the zero-mode waveguide.
- Research Organization:
- Cornell Univ., Ithaca, NY (United States)
- Sponsoring Organization:
- USDOE; National Science Foundation (NSF); National Institutes of Health (NIH)
- DOE Contract Number:
- 066898-0003891; BIR-8800278; P412RR04224-11
- Assignee:
- Cornell Research Foundation, Inc. (Ithaca, NY)
- Patent Number(s):
- 7,181,122
- Application Number:
- 11/313,971
- OSTI ID:
- 1176124
- Resource Relation:
- Patent File Date: 2005 Dec 20
- Country of Publication:
- United States
- Language:
- English
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