Contrast enhancing solution for use in confocal microscopy
A method of optically detecting a tumor during surgery. The method includes imaging at least one test point defined on the tumor using a first optical imaging system to provide a first tumor image. The method further includes excising a first predetermined layer of the tumor for forming an in-vivo defect area. A predetermined contrast enhancing solution is disposed on the in-vivo defect area, which is adapted to interact with at least one cell anomaly, such as basal cell carcinoma, located on the in-vivo defect area for optically enhancing the cell anomaly. Thereafter the defect area can be optically imaged to provide a clear and bright representation of the cell anomaly to aid a surgeon while surgically removing the cell anomaly.
- Research Organization:
- Massachusetts General Hospital, Boston, MA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- FG02-91ER61228
- Assignee:
- The United States of America as represented by the United States Department of Energy (Washington, DC)
- Patent Number(s):
- 7,128,894
- Application Number:
- 10/607,630
- OSTI ID:
- 1175965
- Resource Relation:
- Patent File Date: 2003 Jun 27
- Country of Publication:
- United States
- Language:
- English
In Vivo Confocal Scanning Laser Microscopy of Human Skin II: Advances in Instrumentation and Comparison With Histology11The authors have declared conflict of interest.
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journal | September 1999 |
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