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Title: Microgel particles for the delivery of bioactive materials

Patent ·
OSTI ID:1175778
;

Novel microgels, microparticles and related polymeric materials capable of delivering bioactive materials to cells for use as vaccines or therapeutic agents. The materials are made using a crosslinker molecule that contains a linkage cleavable under mild acidic conditions. The crosslinker molecule is exemplified by a bisacryloyl acetal crosslinker. The new materials have the common characteristic of being able to degrade by acid hydrolysis under conditions commonly found within the endosomal or lysosomal compartments of cells thereby releasing their payload within the cell. The materials can also be used for the delivery of therapeutics to the acidic regions of tumors and sites of inflammation.

Research Organization:
Univ. of California, Oakland, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC03-76SF00098
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Number(s):
7,056,901
Application Number:
10/401,496
OSTI ID:
1175778
Country of Publication:
United States
Language:
English

References (16)

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Synthesis of in Situ Cross-Linkable Macroporous Biodegradable Poly(propylene fumarate- co -ethylene glycol) Hydrogels journal March 2002
Hydrogels for Biomedical Applications journal November 2001
Partitioning of proteins and small biomolecules in temperature- and pH-sensitive hydrogels journal May 1996
Photopolymerizable degradable polyanhydrides with osteocompatibility journal February 1999
Synthesis and Inverse Emulsion Polymerization of Aminated Acrylamidodextran journal December 1993
pH-Responsive Polymer Microspheres: Rapid Release of Encapsulated Material within the Range of Intracellular pH journal May 2001
Bioerodible hydrogels based on photopolymerized poly(ethylene glycol)-co-poly(.alpha.-hydroxy acid) diacrylate macromers journal July 1993
A Novel Strategy for Encapsulation and Release of Proteins:  Hydrogels and Microgels with Acid-Labile Acetal Cross-Linkers journal October 2002
Controlled release of clot-dissolving tissue-type plasminogen activator from a poly(l-glutamic acid) semi-interpenetrating polymer network hydrogel journal July 2001
Temperature modulated protein release from pH/temperature-sensitive hydrogels journal March 1999
A Novel Breakable Cross-Linker and pH-Responsive Star-Shaped and Gel Polymers journal June 1999

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Related Subjects

60 APPLIED LIFE SCIENCES