Inhibitors of glycogen synthase 3 kinase

Patent · Tue May 30 00:00:00 EDT 2006

OSTI ID:1175761

Schultz, Peter; Ring, David B.; Harrison, Stephen D.; Bray, Andrew M.

Compounds of formula 1: ##STR00001## wherein R.sub.1 is alkyl, cycloalkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl, substituted with 0 3 substituents selected from lower alkyl, halo, hydroxy, lower alkoxy, amino, lower alkyl-amino, and nitro; R.sub.2 is hydroxy, amino, or lower alkoxy; R.sub.3 is H, lower alkyl, lower acyl, lower alkoxy-acyl, or amino-acyl; R.sub.4 is H or lower alkyl; and pharmaceutically acceptable salts and esters thereof; are effective inhibitors of GSK3.

• Research Organization: 7 Healthy Communities Institute Corporation; 2 Clinical Computer Systems Incorporated; Chiron Corporation; 3 Pdicta Corporation; 8 Trade Technologies Inc.; 9 Insight Catastrophe Solutions, Llc; 6 Webshade Pty Limited; 0 Pokos Communications Corp; 1 Vaucher Aerospace Corporation; 5 Leica Biosystems Melbourne Pty Lt; 4 Terra Imaging
• Sponsoring Organization: USDOE
• DOE Contract Number: AC03-76SF00098
• Assignee: 7 Healthy Communities Institute Corporation; 2 Clinical Computer Systems Incorporated; Chiron Corporation; 3 Pdicta Corporation; 8 Trade Technologies Inc.; 9 Insight Catastrophe Solutions, Llc; 6 Webshade Pty Limited; 0 Pokos Communications Corp; 1 Vaucher Aerospace Corporation; 5 Leica Biosystems Melbourne Pty Lt; 4 Terra Imaging
• Patent Number(s): 7,053,097
• Application Number: 09/707,548
• OSTI ID: 1175761
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES