Tuning the properties of conjugated polyelectrolytes and application in a biosensor platform
The present invention provides a method of detecting a biological agent including contacting a sample with a sensor including a polymer system capable of having an alterable measurable property from the group of luminescence, anisotropy, redox potential and uv/vis absorption, the polymer system including an ionic conjugated polymer and an electronically inert polyelectrolyte having a biological agent recognition element bound thereto, the electronically inert polyelectrolyte adapted for undergoing a conformational structural change upon exposure to a biological agent having affinity for binding to the recognition element bound to the electronically inert polyelectrolyte, and, detecting the detectable change in the alterable measurable property. A chemical moiety being the reaction product of (i) a polyelectrolyte monomer and (ii) a biological agent recognition element-substituted polyelectrolyte monomer is also provided.
- Research Organization:
- The Regents of the University of California, Los Alamos, CA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- W-7405-ENG-36
- Assignee:
- University Of California, The Regents Of
- Patent Number(s):
- 6,737,279
- Application Number:
- 09/820,402
- OSTI ID:
- 1174849
- Country of Publication:
- United States
- Language:
- English
Similar Records
Electronic Tuning of Mixed Quinoida-Aromatic Conjugated Polyelectrolytes: Direct Ionic Substitution on Polymer Main-Chains
Electronic Tuning of Mixed Quinoidal-Aromatic Conjugated Polyelectrolytes: Direct Ionic Substitution on Polymer Main-Chains