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Title: DNA mobility modifier

Patent ·
OSTI ID:1174816

Polyamides comprising at least one hydrophilic C.sub.1 -C.sub.10 hydrocarbyl substituent on an amide nitrogen atom, and methods for producing and using the same is provided. In particular, polyamides of the formula: ##STR1## and methods for using the same for altering the ratio of charge/translational frictional drag of binding polymers to allow electrophoretic separation of polynucleotides or analogs thereof in a non-sieving liquid medium is provided, where a, q, L.sup.1, P.sup.1, Q.sup.1, R, R.sup.1, R.sup.10 and R.sup.11 are those described herein.

Research Organization:
Northwestern Univ., Evanston, IL (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
FR02-99ER62789
Assignee:
Northwestern University (Evanston, IL)
Patent Number(s):
6,723,515
Application Number:
10/197,613
OSTI ID:
1174816
Country of Publication:
United States
Language:
English

References (13)

[25] Synthesis of N-substituted glycine peptoid libraries book January 1996
Free-solution electrophoresis of DNA journal May 1998
Theory of DNA Sequencing Using Free-Solution Electrophoresis of Protein-DNA Complexes journal May 1994
Solid-Phase synthesis of peptide nucleic acids journal May 1995
Solid Phase Syntheses of Oligoureas journal February 1997
A new concept for sequencing DNA by capillary electrophoresis journal January 1992
Impact of biophysical parameters on the biological assessment of peptide nucleic acids, antisense inhibitors of gene expression journal February 1995
Recent developments in DNA electrophoretic separations journal July 1998
Discovery of Nanomolar Ligands for 7-Transmembrane G-Protein-Coupled Receptors from a Diverse N-(Substituted)glycine Peptoid Library journal August 1994
Separating DNA sequencing fragments without a sieving matrix journal August 1999
Efficient method for the preparation of peptoids [oligo(N-substituted glycines)] by submonomer solid-phase synthesis journal December 1992
Electrophoretic mobility of composite objects in free solution: Application to DNA separation journal January 1996
Mobilities of Labeled and Unlabeled Single-Stranded DNA in Free Solution Electrophoresis journal November 1995

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