Patterned substrates and methods for nerve regeneration

Mallapragada, Surya K.; Heath, Carole; Shanks, Howard; Miller, Cheryl A.; Jeftinija, Srdija

Title: Patterned substrates and methods for nerve regeneration

Patent · Tue Jan 13 00:00:00 EST 2004

OSTI ID:1174676

Mallapragada, Surya K.; Heath, Carole; Shanks, Howard; Miller, Cheryl A.; Jeftinija, Srdija

Micropatterned substrates and methods for fabrication of artificial nerve regeneration conduits and methods for regenerating nerves are provided. Guidance compounds or cells are seeded in grooves formed on the patterned substrate. The substrates may also be provided with electrodes to provide electrical guidance cues to the regenerating nerve. The micropatterned substrates give physical, chemical, cellular and/or electrical guidance cues to promote nerve regeneration at the cellular level.

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Research Organization:: Iowa State Univ., Ames, IA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: W-7405-ENG-82

Assignee:: Iowa State University Research Foundation, Inc. (Ames, IA)

Patent Number(s):: 6,676,675

Application Number:: 09/837,303

OSTI ID:: 1174676

Country of Publication:: United States

Language:: English

References (25)

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