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Title: Computer-aided visualization and analysis system for sequence evaluation

Patent ·
OSTI ID:1174453

A computer system for analyzing nucleic acid sequences is provided. The computer system is used to perform multiple methods for determining unknown bases by analyzing the fluorescence intensities of hybridized nucleic acid probes. The results of individual experiments may be improved by processing nucleic acid sequences together. Comparative analysis of multiple experiments is also provided by displaying reference sequences in one area and sample sequences in another area on a display device.

Research Organization:
Affymetrix, Inc., Santa Clara, CA (United States)
Sponsoring Organization:
USDOE
Assignee:
Affymetrix, Inc. (Santa Clara, CA)
Patent Number(s):
6,607,887
Application Number:
09/796,071
OSTI ID:
1174453
Country of Publication:
United States
Language:
English

References (6)

Light-directed, spatially addressable parallel chemical synthesis journal February 1991
An Algorithm for the DNA Sequence Generation from k-Tuple Word Contents of the Minimal Number of Random Fragments journal April 1991
DNA sequencing by hybridization: 100 bases read by a non-gel-based method. journal November 1991
DNA sequence determination by hybridization: a strategy for efficient large-scale sequencing journal June 1993
Analyzing and comparing nucleic acid sequences by hybridization to arrays of oligonucleotides: Evaluation using experimental models journal August 1992
A sequence assembly and editing program for efficient management of large projects journal January 1991

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Related Subjects

97 MATHEMATICS AND COMPUTING